Stress coping mechanisms in smoking psoriatics

AbstractBackgroundThe link between emotional stress and smoking has previously been investigated and results have suggested that smoking is used as a way of dealing with stress. There are many studies indicating the relationship between smoking and psoriasis or emotional stress and psoriasis. However, to our knowledge, the link between smoking associated with emotional stress and psoriasis has not been shown before. Our aim was to investigate psoriatic patients' abilities to cope with stress, the relationship between coping strategies and smoking habit.MethodsNinety-nine individuals with psoriasis (57 females, and 42 males, mean age: 37.4 years) were included in this study. Sociodemographic information including age, sex, smoking habit, etc., was obtained; Psoriasis Area Severity Index (PASI) scores were recorded. The Fagerstrom Test for Nicotine Dependence was used on smoking patients to evaluate smoking habit or the degree of nicotine dependence. The Ways of Coping Questionnaire and Dermatology Life Quality Index were filled out by all patients. Data were assessed by comparing psoriatic smokers with nonsmokers and statistically analysis was carried out with the SPSS 11.5 program.ResultsForty patients (40.4%) were smokers. When comparing the two groups' mechanisms of coping with stress, smokers and nonsmokers coped with stress in similar ways. The seeking social support scores from the Ways of Coping Questionnaire were significantly lower in smokers than nonsmokers (p<0.05), while the Fagerstrom Test for Nicotine Dependence scores were correlated with distrustful approach sub-scores, and PASI only correlated with smokers. The Dermatology Life Quality Index scores were correlated with the PASI and distrustful approach scores in all patients.ConclusionSmoking and nonsmoking psoriatic patients had similar stress coping strategies, except the subgroup seeking social support, and usually used positive ways of coping with stress. Psoriatic patients who smoke might employ smoking to avoid stressful situations. They would benefit from education on adopting healthy stress management and, in turn, developing mature stress coping mechanisms. Future prospective studies are required to address the exact causal link between smoking, psoriasis and psychiatric comorbidity, including stress coping mechanisms

Panel 10. Paper 10.1: From Understanding to Action for Conservation and Sustainability of a Rural Heritage Place: Kemer, Turkey

Kemer Village, a historic rural settlement situated in western Anatolia, is a very good representative of rural heritage places of this geography. Well-preserved buildings and settlement tissue of the village, provide invaluable information about spatial and architectural features, construction materials and techniques common to this geography. However, upper scale agricultural production and settlement policies, as well as changing ways of living in time, lead to depopulation, discard, alteration and even destruction of Kemer Village. Besides the physical aspects, its intangible aspects, like local living traditions, beliefs, rituals and indigenous knowledge, are also under the risk of disappearing. Although the population of the village decreased significantly in time, there are still inhabitants and local masons living in the village. Thus, it becomes possible to understand the factors, processes and dynamics of change in this rural settlement, so as to be able to define policies, strategies and actions for the conservation and sustainability. Although the common tendency to provide an economic development to prevent depopulation of the rural historic areas is to bring touristic activities, this decision disturbs the integrity of social and physical environment. In Kemer Village this tendency has not been initiated yet. Therefore, Kemer Village is on the border of being abandoned or being a touristic destination. This presentation explains the rural architectural and settlement features of the historical village of Kemer Village, together with indigenous knowledge on living and building traditions, resources and processes. It also discusses the factors, processes and dynamics affecting Kemer Village as an historic rural settlement, and consequently, proposes principles, policies, strategies and actions for the conservation and sustainability of rural heritage place by including all the decision makers, inhabitants and experts to the shared decision-making process

Psoriasis Symptom Inventory (PSI) as a patient-reported outcome in mild psoriasis: Real life data from a large psoriatic arthritis registry

Objective: Our aim is to test the validity of the Psoriasis Symptom Inventory (PSI), a patient-reported outcome, to assess the psoriasis severity within the scope of rheumatology. Methods: Within the PsA international database (PSART-ID), 571 patients had PSI, while 322 of these also showed body surface area (BSA). Correlations between PSI, BSA, and other patient- and physician-reported outcomes were investigated. Results: There was a good correlation between PSI and BSA (r=0.546, p<0.001), which was even higher for mild psoriasis (BSA<3 (n=164): T-0.608, p<0.001). PSI significantly correlated with fatigue, pain, and patient and physician global parameters (p<0.001). Conclusion: PSI has a good correlation with other patient- and physician-reported outcomes, and our findings support its use in rheumatology practice

CD4(+) T cells of myasthenia gravis patients are characterized by ıncreased IL-21, IL-4, and IL-17A productions and higher presence of PD-1 and ICOS

Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies predominantly against the acetylcholine receptor (AChR). Specific T cell subsets are required for long-term antibody responses, and cytokines secreted mainly from CD4(+) T cells regulate B cell antibody production. The aim of this study was to assess the differences in the cytokine expressions of CD4(+) T cells in MG patients with AChR antibodies (AChR-MG) and the effect of immunosuppressive (IS) therapy on cytokine activity and to test these findings also in MG patients without detectable antibodies (SN-MG). Clinically diagnosed AChR-MG and SN-MG patients were included. The AChR-MG patients were grouped as IS-positive and -negative and compared with age- and sex-matched healthy controls. Peripheral blood mononuclear cells were used for ex vivo intracellular cytokine production, and subsets of CD4(+) T cells and circulating follicular helper T (cTfh) cells were detected phenotypically by the expression of the chemokine and the costimulatory receptors. Thymocytes obtained from patients who had thymectomy were also analyzed. IL-21, IL-4, IL-10, and IL-17A productions in CD4(+) T cells were increased in AChR-MG compared to those in healthy controls. IS treatment enhanced IL-10 and reduced IFN-gamma production in AChR-MG patients compared to those in IS-negative patients. Increased IL-21 and IL-4 productions were also demonstrated in SN-MG patients. Among CD4(+) T cells, Th17 cells were increased in both disease subgroups. Treatment induced higher proportions of Th2 cells in AChR-MG patients. Both CXCR5(+) and CXCR5(-) CD4(+) T cells expressed higher programmed cell death protein 1 (PD-1) and inducible costimulatory (ICOS) in AChR-MG and SN-MG groups, mostly irrespective of the treatment. Based on chemokine receptors on CXCR5(+)PD-1(+) in CD4(+) T (cTfh) cells, in AChR-MG patients without treatment, the proportions of Tfh17 cells were higher than those in the treated group, whereas the Tfh1 cells were decreased compared with those in the controls. The relevance of CXCR5 and PD-1 in the pathogenesis of AChR-MG was also suggested by the increased presence of these molecules on mature CD4 single-positive thymocytes from the thymic samples. The study provides further evidence for the importance of IL-21, IL-17A, IL-4, and IL-10 in AChR-MG. Disease-related CD4(+)T cells are identified mainly as PD-1(+) or ICOS+ with or without CXCR5, resembling cTfh cells in the circulation or probably in the thymus. AChR-MG and SN-MG seem to have some similar characteristics. IS treatment has distinctive effects on cytokine expression.Istanbul Universit

Clinical and genetic spectrum of an orphan disease MPAN: a series with new variants and a novel phenotype

Introduction. Pathogenic variations in C19orf12 are responsible for two allelic diseases: mitochondrial membrane protein-associated neurodegeneration (MPAN); and spastic paraplegia type 43 (SPG43). MPAN is an orphan disease, which presents with spasticity, dystonia, peripheral nerve involvement, and dementia. The pattern of iron accumulation on brain MRI may be a clue for the diagnosis of MPAN. SPG43, on the other hand, is characterised by progressive lower limb spasticity without brain iron accumulation. We here present clinical and genetic findings of MPAN patients with potentially pathogenic C19orf12 variants.Materials and methods. Patients from 13 different families having progressive motor symptoms with irritative pyramidal signs and brain iron accumulation were screened for C19orf12 gene variants.Results. C19orf12 screening identified seven variants associated with MPAN in eight patients from seven families. We associated two pathogenic variants (c.24G &gt; C; p.(Lys8Asn) and c.194G &gt; A; p.(Gly65Glu)) with the MPAN phenotype for the first time. We also provided a genetic diagnosis for a patient with an atypical MPAN presentation. The variant c.32C &gt; T; p.(Thr11Met), common to Turkish adult-onset MPAN patients, was also detected in two unrelated late-onset MPAN patients.Conclusions. Genetic analysis along with thorough clinical analysis supported by radiological findings will aid the differential diagnosis of MPAN within the neurodegeneration with brain iron accumulation spectrum as well as other disorders including hereditary spastic paraplegia. Dystonia and parkinsonism may not be the leading clinical findings in MPAN patients, as these are absent in the atypical case. Finally, we emphasise that the existence of frameshifting variants may bias the age of onset toward childhood

5e Öğrenme Modeline Dayalı Etkinliklerin Coğrafya Dersi Çevre ve Toplum Konularının Öğrenme Sürecine Etkisi

Araştırmanın amacı Coğrafya dersinde yapılandırmacı yaklaşım, 5E modeline göre öğrenim gören deney grubu öğrencileri ile programa dayalı öğrenim gören kontrol grubu öğrencilerinin dersteki başarıları ve derse karşı tutumları arasında ön test ve son test ölçümleri arasında anlamlı bir farklılık olup olamadığının belirlenmesidir. Araştırmada kontrol gruplu ön test- son test deneysel araştırma modeli kullanılmıştır. 2010-2011 eğitim-öğretim yılında 10. sınıf öğrencilerinden rasgele seçilen bir deney bir de kontrol grubu araştırmanın örneklemini oluşturmuştur. Öğrencilere “Başarı Testi” ve likert tipi “Coğrafya Dersi Tutum Ölçeği” kullanılmıştır. Çözümlemede sayı, yüzde, ortalamalardan yararlanılmış ve tek faktör üzerinde tekrarlı ölçümler için iki faktörlü ANOVA (two-way ANOVA for repeated measures) teknikleri uygulanmıştır. Araştırma bulgularına göre yapılandırmacı yaklaşım 5E modelinin kullanıldığı deney grubu öğrencilerinin akademik başarıları ve coğrafya dersine yönelik tutumları kontrol grubundaki öğrencilere göre anlamlı düzeyde artış göstermiştir (

The effect of constructivist approach 5E Model on 10th grade geography class (environment and society learning area) academic success and tendency

Bu araştırmanın amacı, ortaöğretim 10. sınıf coğrafya dersi “Çevre ve Toplum” öğrenme alanının kapsamına giren konuların öğretiminde yapılandırmacı yaklaşım 5E modeline göre hazırlanmış etkinliklere dayalı öğrenme ortamlarının öğrencinin akademik başarısı ve coğrafya dersine yönelik tutumları üzerine etkilerini incelemektir. Araştırma yöntemi olarak kontrol gruplu ön test- son test deneysel araştırma modeli kullanılmıştır. Araştırmada, öğrencilerin akademik başarılarındaki değişimi ölçmek için araştırmacı tarafından geliştirilen “40 soruluk Akademik Başarı Testi,” coğrafya dersine yönelik tutumlarını ölçmek için ise Demirkaya (2003)’dan yararlanarak, Coşkun (2004)’un geliştirdiği likert türü “Coğrafya Dersi Tutum Ölçeği” kullanılmıştır. Çalışmanın alt problemlerinin çözümlenmesinde ve deney ve kontrol gruplarının ön test puanlarının karşılaştırılmasında,frekans, yüzde ve aritmetik ortalama kullanılmış, ayrıca tek faktör üzerinde tekrarlı ölçümler için iki faktörlü Anova ( two-way Anova for repeated measures) teknikleri uygulanmıştır. Bu araştırmanın örneklemini 2010-2011 eğitim öğretim yılının 2. yarıyılında Bursa Yıldırım Merkez İmam Hatip Lisesi 10. sınıf öğrencilerinden bir deney birde kontrol grubu oluşturmaktadır. Toplam 72 kız öğrenci üzerinde bu araştırma yapılmıştır. Deney grubunda 5E modeline dayalı, kontrol grubunda ise öğretmenin tercihine bağlı 5E modeli dışındaki öğrenme ortamları oluşturularak ders işlenmiştir. Araştırmanın bulgularına göre Yapılandırmacı yaklaşım 5E modelinin kullanıldığı deney grubu öğrencilerinin akademik başarıları ve coğrafya dersine yönelik tutumları kontrol grubundaki öğrencilere göre anlamlı düzeyde farklılık göstermiştir.The aim of this research is to study the influence of learning designed in accordance with Constructivist 5E model activities on students’s academic success and their attitudes towards geography classes while teaching “Environment and Society,” a secondary school 10th grade subject. The basic research method is the pre-test/post-test experimental research technique with control groups. Throughout the research, a 40-question Academic Success Test developed by the candidate has been used in order to measure the change in students’s success. In addition to this test, to observe students’s reception of geography class, Demirkaya (2003), and the “Geography Class Behavioural Scale,” a likert scale developed by Coşkun (2004), have also been applied. Along with the 2x2 t-test (pre-test / post-test model with control groups), one-way variant test (repeated measures) has been adopted while analysing the sub-problems of the study and comparing the pre-test grades of test and control groups. The study has been carried out by studying on a test group and a control group from Yıldırım Merkez İmam Hatip Lycee 10th grade students in the Spring term of 2010-2011 academic year. A total of 76 female students have kindly taken part in the study. Classes based on 5E model have been conducted with the test group while teachers have been given the chance to choose and shape their teaching environment from other methods other than 5E model for the control group. The results have shown that the test group exposed to Constructivist 5E model has achieved considerable success and developed a keener behaviour towards geography classes in comparison with the control group students

The interrogation of teachers' attitudes accordingt to their subjects

Bu araştırmanın amacı öğretmen tutumlarının hangi özeliklerinin branşlara göre farklılık gösterdiğinin saptanmasıdır. Ayrıca yaş, cinsiyet, kıdem, medeni durum ve mezun olunan fakülte (eğitim/fen-edebiyat) parametrelerine göre tutum farklılıkları sorgulanmak istenmiştir. Kesitsel tipte olan bu araştırmanın örneklemini 2011-1012 öğretim yılı bahar yarıyılında, Bursa ili MEB ortaöğretim kurumlarında görev yapan 250 branş öğretmeni oluşturmaktadır. Veriler yüz yüze görüşme tekniği ile “Branş Öğretmenleri Tutum Ölçeği” uygulanarak toplanmıştır. Branş Öğretmenleri Tutum Ölçeği; ''mesleki sorumluluk ve ayrımcılık'' (boyut 1), "insancıl düşünsel yaklaşım'' (boyut 2), "öğrenci ve öğrenmeye karşı tutum" (boyut 3) ve "mesleğe karşı tutum" (boyut 4) alt alanlarından oluşmaktadır. Orta Öğretim kurumlarında çalışan 14 farklı branşı kapsayan veri toplama aracı; öğretmenin toplumsal ve mesleki kimliği ile öğretmenlik mesleğine bakışlarını saptamaya yönelik beşli likert tipte ve 47 maddeden oluşan bir ölçektir. Veriler t testi, varyans analizi (ANOVA) istatistik yöntemleri kullanılarak, Excel 7.0 ve SPSS 13.0 istatistik programında değerlendirilmiştir.Araştırma bulgularına göre; tüm branşlarda mezun olunan fakülte ile öğretmenlik tutumları (boyut 1, 2, 3, 4) arasında istatistiksel olarak anlamlı bir ilişki (p<0.05) olmakla birlikte, sözel branşlarda (Türkçe, tarih, coğrafya, yabancı dil…) sayısal branşlara göre daha fazla mesleki sorumluluk sahibi oldukları ve ayrımcılığa karşı daha duyarlı oldukları ortaya çıkmıştır. Branş Öğretmenleri Tutum Ölçeği alt alanlarından “boyut 2”soruları incelendiğinde; sözel branşların sayısal branşlara göre pozitif bir yaklaşım içinde oldukları görülmektedir. “Boyut 3” sorularına bakıldığında; sayısal branşların, sözel branşlara göre daha olumsuz tutumlar sergileme eğiliminde oldukları belirlenmiştir. “boyut 4” sorularında sayısal ve sözel branşlar arasında anlamlı farka rastlanmamakla birlikte, sayısal branşların bu konuda daha duyarlı oldukları anlaşılmaktadır. Eğitim fakültelerinden mezun olan öğretmenlerin, boyut 2, boyut 3 ve boyut 4 sorularında öğretmen yetiştirmeyen fakültelerden mezun olan öğretmenlere göre anlamlı derecede daha olumlu tutumlar sergiledikleri ortaya koyulmuştur. “boyut 1” ve “boyut 3” te ise bu iki grup arasında anlamlı bir fark olmadığı belirlenmiştir. 1-5 yıl arası deneyime sahip olan öğretmenlerin, daha fazla deneyime sahip olan öğretmenlerden ''mesleki sorumluluk ve ayrımcılık'' 1. boyutta anlamlı derecede daha olumsuz bir tutum içinde oldukları belirlenmişken, "insancıl düşünsel yaklaşım ve öğrenme" (boyut 2) ve "öğrenciye karşı tutum" (boyut 3) konularında sergiledikleri tutumların tecrübe yılına göre farklılık göstermediği yönündedir. Analiz sonuçlarına göre, mesleki sorumluluk ve ayrımcılık boyutunda (boyut l) evli öğretmenlerin evli olmayanlara göre anlamlı derecede daha sorumlu ve duyarlı oldukları görülmektedir. Buna karşın boyut 2’de evli olmayan öğretmenlerin evli öğretmenlere göre anlamlı derecede daha olumlu bir tutum sergiledikleri görülmektedir. 3. ve 4.boyutta evli ve evli olmayan öğretmenler arasında anlamlı bir fark yoktur. Bayan öğretmenlerin erkek öğretmenlere göre anlamlı derecede mesleki sorumluluk sahibi oldukları ve ayırımcılıklara karşı da daha duyarlı oldukları ortaya çıkan diğer sonuçlar arasındadır.In this research, it was aimed to determine which characteristics ofteachers’ attitudes differentiate according to their subjects. The research in cross-sectional form. Consists of 250 teachers working at schools of Bursa Ministery Education in the second therm, 2011-2012.The data was collected by applying the technique of force to face negotiation. The scale of branch teachers’ attitudes consists of these sub-subjects: ‘’Professional Responsibility and Differentation’’ ‘’Humane ideational Approach’’ and ‘’The attitide towards teachers and students’’ It is a kind of scale which consists of 40 items and five likert types to determire the social and Professional identites of different branch teachers’ and their approachto to the occupation of teaching. The data is evaluated in stastic programs suchas Excel 70 and SPS 13,0 by using t test, Variance Analysis, Statics Techniques.According to the findings obtained in the results of evoulating, it has been understood that there is a connection between the foculty from which graduated and attitudes of teachers’ and the ones working on literature and social studies are more responsible for their professions and more senstive to discrimination then there working on science. When subsubjects are scrutinized, different results can be obtained

The effect of constructivist approach 5E Model on 10th grade geography class (environment and society learning area) academic success and tendency

Bu araştırmanın amacı, ortaöğretim 10. sınıf coğrafya dersi Çevre ve Toplum öğrenme alanının kapsamına giren konuların öğretiminde yapılandırmacı yaklaşım 5E modeline göre hazırlanmış etkinliklere dayalı öğrenme ortamlarının öğrencinin akademik başarısı ve coğrafya dersine yönelik tutumları üzerine etkilerini incelemektir. Araştırma yöntemi olarak kontrol gruplu ön test- son test deneysel araştırma modeli kullanılmıştır. Araştırmada, öğrencilerin akademik başarılarındaki değişimi ölçmek için araştırmacı tarafından geliştirilen 40 soruluk Akademik Başarı Testi, coğrafya dersine yönelik tutumlarını ölçmek için ise Demirkaya (2003)'dan yararlanarak, Coşkun (2004)'un geliştirdiği likert türü Coğrafya Dersi Tutum Ölçeği kullanılmıştır. Çalışmanın alt problemlerinin çözümlenmesinde ve deney ve kontrol gruplarının ön test puanlarının karşılaştırılmasında,frekans, yüzde ve aritmetik ortalama kullanılmış, ayrıca tek faktör üzerinde tekrarlı ölçümler için iki faktörlü Anova ( two-wayAnovaforrepeatedmeasures) teknikleri uygulanmıştır. Bu araştırmanın örneklemini 2010-2011 eğitim öğretim yılının 2. yarıyılında Bursa Yıldırım Merkez İmam Hatip Lisesi 10. sınıf öğrencilerinden bir deney birde kontrol grubu oluşturmaktadır. Toplam 72 kız öğrenci üzerinde bu araştırma yapılmıştır. Deney grubunda 5E modeline dayalı, kontrol grubunda ise öğretmenin tercihine bağlı 5E modeli dışındaki öğrenme ortamları oluşturularak ders işlenmiştir. Araştırmanın bulgularına göre Yapılandırmacı yaklaşım 5E modelinin kullanıldığı deney grubu öğrencilerinin akademik başarıları ve coğrafya dersine yönelik tutumları kontrol grubundaki öğrencilere göre anlamlı düzeyde farklılık göstermiştir.The aim of this research is to study the influence of learning designed in accordance with Constructivist 5E model activities on students's academic success and their attitudes towards geography classes while teaching Environment and Society, a secondary school 10th grade subject. The basic research method is the pre-test/post-test experimental research technique with control groups. Throughout the research, a 40-question Academic Success Test developed by the candidate has been used in order to measure the change in students's success. In addition to this test, to observe students's reception of geography class, Demirkaya (2003), and the Geography Class Behavioural Scale, a likert scale developed by Coşkun (2004), have also been applied. Along with the 2x2 t-test (pre-test / post-test model with control groups), one-way variant test (repeated measures) has been adopted while analysing the sub-problems of the study and comparing the pre-test grades of test and control groups. The study has been carried out by studying on a test group and a control group from Yıldırım Merkez İmam Hatip Lycee 10th grade students in the Spring term of 2010-2011 academic year. A total of 76 female students have kindly taken part in the study. Classes based on 5E model have been conducted with the test group while teachers have been given the chance to choose and shape their teaching environment from other methods other than 5E model for the control group. The results have shown that the test group exposed to Constructivist 5E model has achieved considerable success and developed a keener behaviour towards geography classes in comparison with the control group students