23 research outputs found
The Role Of Tax And Transfers In Reducing Personal Income Inequality In EuropeÃs Regions: Evidence From EUROMOD
In this paper we use statistical tools and graphic devices in order to give a comprehensive picture of income inequality levels in a set of 100 EU-15 regions at the end of the XX century before and after the operation of the tax-benefit. Our analysis is based on EUROMOD, the first multi-country tax-benefit model built with a common framework that includes detailed information on taxes and benefits paid and received by individuals and/or households from samples that are representative for the 15 EU countries. Our analysis focuses on intraregional inequality and it explores the relationship between regional inequality levels (both in market incomes and disposable incomes) and economic performance. Our main findings indicate that tax-benefits systems in Europe notably reduce market inequality in all EU regions and that the size of this reduction (i.e. redistributive effect) depends crucially on (i) the market inequality level of the region (positively), (ii) the relative economic performance of the region in the country (negatively) and (iii) the country to which the region belongs.European Union, Regions, inequality, redistribution, economic performance
The impact of means tested assistance in Southern Europe
This paper aims to analyse the social assistance systems in five South European countries: France, Greece, Italy, Portugal and Spain. After reviewing the existing system of social assistance in each country, we apply a consistent methodology in order to estimate its impact on income distribution, poverty and target efficiency
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
Background: Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods: The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results: A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion: Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)
Equivalence scales and inequality
At the heart of any distributional analysis there is the problem of allowing for differences in people's non-income characteristics. We examine the role of standard equivalence scales in distributional comparisons and the welfare implications of the basis for constructing equivalence scales. We consider the use of alternative approaches that do not require the specification of a single scale and implement one of these in practical comparison of Spain and the UK
Reforming Family Transfers in Southern Europe: Is there a Role for Universal Child benefits?
The paper examines the effect of income transfers to families in Greece, Italy, Spain and Portugal using a benefit-tax model. The distributional impact of actual programmes is shown to be weak, hence the scope for reform great. As an illustration, the European benefit-tax model EUROMOD is used to simulate universal child benefits equivalent to those in Britain, Denmark and Sweden. The anti-poverty effect of such benefits is found to be in proportion to their fiscal cost
Family Transfers and Child Poverty in Greece, Italy, Spain and Portugal
The paper examines the effect of family transfers on child poverty in Greece, Italy, Spain and Portugal. Family transfers are defined as to include non-contributory child benefits, contributory family allowances and tax credits or allowances. The drive to reduce child poverty is of particular interest in Southern Europe, where public support to poor families with children is often neagre or not available at all. The paper uses te European cross-country microsimulation model, EUROMOD, to assess the distributional impact of existing family transfers and to explore the scope for policy reforms, before it concludes with a discussion of key findings and policy applications
Family Transfers and Child Poverty in Greece, Italy, Spain and Portugal
The paper examines the effect of family transfers on child poverty in Greece, Italy, Spain and Portugal. Family transfers are defined as to include non-contributory child benefits, contributory family allowances and tax credits or allowances. The drive to reduce child poverty is of particular interest in southern Europe, where public support to poor families with children is often meagre or not available at all. The paper uses the European cross-country microsimulation model, EUROMOD, to assess the distributional impact of existing family transfers and to explore the scope for policy reforms, before it concludes with a discussion of key findings and policy implications
Changes in Circulating MicroRNAs Are Associated With Childhood Obesity
Abstract
Context:
Circulating microRNAs (miRNAs) are valuable biomarkers of metabolic diseases and potential therapeutic targets in this field.
Objective:
Our objective was to define the circulating pattern of miRNAs in childhood obesity.
Design, Settings, and Main Outcome Measure:
The genome-wide circulating miRNA profile was assessed by RT-PCR in 10 boys (5 lean and 5 obese children). The most relevant miRNAs were cross-sectionally validated in 85 lean versus 40 obese children (63 boys and 62 girls) and longitudinally evaluated in samples from the same children when they were ∼7 and ∼10 years old (23 boys and 22 girls).
Results:
The cross-sectional validation study disclosed that 15 specific circulating miRNAs were significantly deregulated in prepubertal obesity, including the decreased miR-221 and miR-28-3p and increased concentrations in plasma of miR-486-5p, miR-486-3p, miR-142-3p, miR-130b, and miR-423-5p (all P &lt; .0001). The circulating concentration of these miRNAs was significantly associated with body mass index and other measures of obesity such as percent fat mass, waist, regional fat distribution and with laboratory parameters such as homeostasis model assessment of insulin resistance, high-molecular-weight adiponectin, C-reactive protein, and circulating lipids in concordance with anthropometric associations. Plasma concentrations of 10 of these circulating miRNAs changed significantly and differently during the 3-year follow-up in children who increased or decreased their normalized weight.
Conclusion:
This study provides the first evidence that circulating miRNAs are deregulated in prepubertal obese children. Thus, the very early detection of an abnormal circulating miRNA profile may be a promising strategy to identify obese children who may suffer from metabolic abnormalities.
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Equivalence of scales and inequality
SIGLEAvailable from British Library Document Supply Centre-DSC:3597.4455(27) / BLDSC - British Library Document Supply CentreGBUnited Kingdo
