6,004 research outputs found
Altered progesterone concentrations by hormonal manipulations before a fixed-time artificial insemination CO-Synch + CIDR program in suckled beef cows
We hypothesized that pregnancy outcomes may be improved by inducing luteal regression, ovulation, or both (i.e., altering progesterone status) before initiating a timedâartificial insemination (TAI) program in suckled beef cows. This hypothesis was tested in two experiments in which cows were treated with either PGF[subscript 2α] (PG) or PG + GnRH before initiating a TAI program to increase the proportion of cows starting the program in a theoretical marginal (<1 ng/mL; experiment 1) or elevated (â„1 ng/mL; experiment 2) progesterone environment, respectively. The control was a standard CO-Synch + controlled internal drug release (CIDR) program employed in suckled beef cows (100 ÎŒg GnRH intramuscularly [IM] [GnRH-1] and insertion of a progesterone-impregnated intravaginal CIDR insert on study Day â10, 25 mg PG and CIDR insert removal on study Day â3, and 100 ÎŒg GnRH IM [GnRH-2] and TAI on study Day 0). In both experiments, blood was collected before each injection for later progesterone analyses. In experiment 1, cows at nine locations (n = 1537) were assigned to either: (1) control or (2) PrePG (same as control with a PG injection on study Day â13). The PrePG cows had larger (P < 0.05) follicles on study Day â10 and more (P < 0.05) ovulated after GnRH-1 compared with control cows (60.6% vs. 36.5%), but pregnancy per TAI was not altered (55.5% vs. 52.2%, respectively). In experiment 2, cows (n = 803) at four locations were assigned to: (1) control or (2) PrePGG (same as control with PG injection on study Day â20 and GnRH injection on study Day â17). Although pregnancy per TAI did not differ between control and PrePGG cows (44.0% vs. 44.4%, respectively), cows with body condition score greater than 5.0 or 77 or more days postpartum at TAI were more (P < 0.05) likely to become pregnant than thinner cows or those with fewer days postpartum. Presynchronized cows in both experiments were more (P < 0.05) likely than controls to have luteolysis after initial PG injections and reduced (P < 0.05) serum progesterone; moreover, treatments altered the proportion of cows and pregnancy per TAI of cows in various progesterone categories before the onset of the TAI protocol. In combined data from both experiments, cows classified as anestrous before the study but with elevated progesterone on Day â10 had increased (P < 0.05) pregnancy outcomes compared with anestrous cows with low progesterone concentrations. Progesterone concentration had no effect on pregnancy outcome of cycling cows. In summary, luteal regression and ovulation were enhanced and progesterone concentrations were altered by presynchronization treatments before the 7-day CO-Synch + CIDR program, but pregnancy per TAI was not improved
Quartic Anomalous Couplings in Colliders
We study the constraints on the vertices ,
, and that can be obtained from
triple-gauge-boson production at the next generation of linear
colliders operating in the mode. We analyze the processes
(, or ) and show that these reactions
increase the potential of machines to search for anomalous
four-gauge-boson interactions.Comment: 15 pages, Latex file using ReVteX, 4 uufiled figures include
Cancer pain management in an oncological ward in a comprehensive cancer center with an established palliative care unit.
Abstract
BACKGROUND:
This survey was performed to draw information on pain prevalence, intensity, and management from a sample of patients who were admitted to an oncologic center where a palliative care unit (PCU) has been established for 13 years.
METHODS:
Cross-sectional survey in an oncological department performed 1 day per month for six consecutive months.
RESULTS:
Of the 385 patients, 69.1, 19.2, 8.6, and 3.1 % had no pain, mild, moderate, and severe pain, respectively. Inpatients and patients with a low Karnofsky score showed higher levels of pain intensity (pâ<â0.0005). One hundred twenty-eight patients with pain or receiving analgesics were analyzed for pain management index (PMI). Only a minority of patients had negative PMI score, which was statistically associated with inpatient admission (pâ=â0.011). Fifty of these 128 patients had breakthrough pain (BTP), and all of them were receiving some medication for BTP.
CONCLUSION:
It is likely that the presence of PCU team providing consultation, advices, and cultural pressure, other than offering admissions for difficult cases had a positive impact on the use of analgesics, as compared with previous similar surveys performed in oncological setting, where a PCU was unavailable. This information confirms the need of the presence of a PCU in a high volume oncological department
Breakthrough pain in oncology: a longitudinal study.
Abstract
CONTEXT: Existing studies on breakthrough pain (BP) have reported different prevalence rates because of different settings, populations, and assessment methods. These studies have used cross-sectional designs, and the relationship of BP with analgesic treatment has not been evaluated.
OBJECTIVES: The aim of this study was to longitudinally assess BP in cancer patients admitted to oncology units.
METHODS: A consecutive sample of patients admitted to oncology centers was selected. At admission (T0), three months after admission (T3), and six months after admission (T6), data on background pain and BP were recorded. BP was assessed in terms of its intensity, duration, number of episodes, onset with movement, spontaneous relief after stopping activity, limitation of physical activity, and effectiveness of analgesics.
RESULTS: Three hundred two patients completed the study. At T0, T3, and T6, 39%, 38%, and 33% patients, respectively, had continuous pain (P=0.294). Pain intensity significantly decreased (P=0.004 and 0.027 at T3 and T6, respectively). Most patients had BP at T0 (87.1%), T3 (80.9%), and T6 (73.2%), and there was a significant decrease in the prevalence of BP over time (P=0.016). Of 149 patients with BP, pain on movement was recorded in 43.6%, 43.4%, and 32.4% at T0, T3, and T6, respectively (P=0.228). Pain spontaneously decreased or ceased when stopping physical activity in 66%, 56%, and 62% at T0, T3, and T6, respectively (P=0.537). Pain on movement strongly limited physical activity in most patients.
CONCLUSION: These data expand current information about BP and underline the need for a longitudinal assessment of a phenomenon that is invariably dependent on stage of disease, patient, and therapeutic factors
New Cases of Universality Theorem for Gravitational Theories
The "Universality Theorem" for gravity shows that f(R) theories (in their
metric-affine formulation) in vacuum are dynamically equivalent to vacuum
Einstein equations with suitable cosmological constants. This holds true for a
generic (i.e. except sporadic degenerate cases) analytic function f(R) and
standard gravity without cosmological constant is reproduced if f is the
identity function (i.e. f(R)=R). The theorem is here extended introducing in
dimension 4 a 1-parameter family of invariants R' inspired by the
Barbero-Immirzi formulation of GR (which in the Euclidean sector includes also
selfdual formulation). It will be proven that f(R') theories so defined are
dynamically equivalent to the corresponding metric-affine f(R) theory. In
particular for the function f(R)=R the standard equivalence between GR and
Holst Lagrangian is obtained.Comment: 10 pages, few typos correcte
First Results from the TOTEM Experiment
The first physics results from the TOTEM experiment are here reported,
concerning the measurements of the total, differential elastic, elastic and
inelastic pp cross-section at the LHC energy of = 7 TeV, obtained
using the luminosity measurement from CMS. A preliminary measurement of the
forward charged particle distribution is also shown.Comment: Conference Proceeding. MPI@LHC 2010: 2nd International Workshop on
Multiple Partonic Interactions at the LHC. Glasgow (UK), 29th of November to
the 3rd of December 201
Elastic Scattering and Total Cross-Section in p+p reactions measured by the LHC Experiment TOTEM at sqrt(s) = 7 TeV
Proton-proton elastic scattering has been measured by the TOTEM experiment at
the CERN Large Hadron Collider at TeV in special runs with the
Roman Pot detectors placed as close to the outgoing beam as seven times the
transverse beam size. The differential cross-section measurements are reported
in the |t|-range of 0.36 to 2.5 GeV^2. Extending the range of data to low t
values from 0.02 to 0.33 GeV^2,and utilizing the luminosity measurements of
CMS, the total proton-proton cross section at sqrt(s) = 7 TeV is measured to be
(98.3 +- 0.2(stat) +- 2.8(syst)) mb.Comment: Proceedings of the XLI International Symposium on Multiparticle
Dynamics. Accepted for publication in Prog. Theor. Phy
LHC Optics Measurement with Proton Tracks Detected by the Roman Pots of the TOTEM Experiment
Precise knowledge of the beam optics at the LHC is crucial to fulfil the
physics goals of the TOTEM experiment, where the kinematics of the scattered
protons is reconstructed with the near-beam telescopes -- so-called Roman Pots
(RP). Before being detected, the protons' trajectories are influenced by the
magnetic fields of the accelerator lattice. Thus precise understanding of the
proton transport is of key importance for the experiment. A novel method of
optics evaluation is proposed which exploits kinematical distributions of
elastically scattered protons observed in the RPs. Theoretical predictions, as
well as Monte Carlo studies, show that the residual uncertainty of this optics
estimation method is smaller than 0.25 percent.Comment: 20 pages, 11 figures, 5 figures, to be submitted to New J. Phy
The Reach of the CERN Large Hadron Collider for Gauge-Mediated Supersymmetry Breaking Models
We examine signals for sparticle production at the CERN Large Hadron Collider
(LHC) within the framework of gauge mediated supersymmetry breaking models with
a low SUSY breaking scale for four different model lines, each of which leads
to qualitatively different signatures. We first examine the reach of the LHC
via the canonical E_T^miss and multilepton channels that have been advocated
within the mSUGRA framework. Next, we examine special features of each of these
model lines that could serve to further enhance the SUSY signal over Standard
Model backgrounds. We use ISAJET to evaluate the SUSY reach of experiments at
the LHC. We find that the SUSY reach, measured in terms of m(gluino), is at
least as large, and sometimes larger, than in the mSUGRA framework. In the best
case of the co-NLSP scenario, the reach extends to m(gluino) >~ 3 TeV, assuming
10 fb^-1 of integrated luminosity.Comment: 30 page Revtex file plus 12 EPS figure
Proton-proton elastic scattering at the LHC energy of {\surd} = 7 TeV
Proton-proton elastic scattering has been measured by the TOTEM experiment at
the CERN Large Hadron Collider at {\surd}s = 7 TeV in dedicated runs with the
Roman Pot detectors placed as close as seven times the transverse beam size
(sbeam) from the outgoing beams. After careful study of the accelerator optics
and the detector alignment, |t|, the square of four-momentum transferred in the
elastic scattering process, has been determined with an uncertainty of d t =
0.1GeV p|t|. In this letter, first results of the differential cross section
are presented covering a |t|-range from 0.36 to 2.5GeV2. The differential
cross-section in the range 0.36 < |t| < 0.47 GeV2 is described by an
exponential with a slope parameter B = (23.6{\pm}0.5stat {\pm}0.4syst)GeV-2,
followed by a significant diffractive minimum at |t| =
(0.53{\pm}0.01stat{\pm}0.01syst)GeV2. For |t|-values larger than ~ 1.5GeV2, the
cross-section exhibits a power law behaviour with an exponent of -7.8_\pm}
0.3stat{\pm}0.1syst. When compared to predictions based on the different
available models, the data show a strong discriminative power despite the small
t-range covered.Comment: 12pages, 5 figures, CERN preprin
- âŠ