The Influence of Media News Frame on Consumer’s Brand Attitudes in the Context of Product-harm Crisis

This article examines the relationships between the media news frame and consumer brand attitude after the product-harm crisis. Based on the past classification about negative events, this article divides the media news frame into two kinds: disability type and immoral type. By a 2(media frame: disability VS immorality) * 2 ( severity of crisis: high VS low) experiment, the findings show that in the case of product harm crisis, the customer brand attitude is more significantly affected by the immoral type media news frame. In the meanwhile, the significance of this frame effect is affected by cognitive need and severity of crisis. For the consumers with high cognitive need, the frame effect is not obvious. But for the ones with low cognitive need, the frame effect is obvious. The customer brand attitude is more obviously affected by the media news frame in a circumstance of high crisis than low crisis. Therefore, when a product-harm crisis happened, the firms should care about the news reporting format so that the customer brand attitude will not be seriously damaged and the brand image can be well restored

Research progress in physiological effects of resistant substances of Urtica dioica L. on animal performance and feed conversion

Several members of family Urticaceae are mainly found in the temperate and subtropical zones of the Northern Hemisphere and are important medicinal plants. Among them, Urtica dioica L. (Urticaceae) is an annual or perennial herb that has been used for feeding and medicinal purposes since long time and is the most exploited species of Urticaceae. Recently, it has received attention to be used as animal feed, as its fresh leaves fed to animals in moderate, dried, and other forms. This review details the advantages of U. dioica as an alternative feed in terms of germplasm specificity, nutritional composition, and feed application status. Its roots, stems, leaves, and seeds are rich in active ingredients. It has also been found to have anticancer effects through antioxidant action and promotion of apoptosis of cancer cells. In shady conditions, U. dioica is highly adaptable while under stressful conditions of drought; it also reduces light absorption and ensures carbon assimilation through light energy conversion efficiency. Therefore, it can be added to animal diets as a suitable feed to reduce costs and improve economic efficiency. This paper investigates the feasibility of using U. dioica as a feed and systematically presents the progress of research and exploitation of U. dioica

Very Low Frequency Propagation Characteristics Analysis in Coal Mines

Electromagnetic wave penetration coal-rock communication is a significant part for the smart mine communication technology, there are great challenges for electromagnetic wave is rapidly attenuated by factors such as geology and coal seam structure. In order to provide a theory basis for wireless communication technology development in coal rock, based on the Maxwell's equations, this paper establishes a physical model of wireless communication under the conditions of coal seam. To characterize the performance of the electromagnetic wave propagation, we use the Maxwell's equations to derive the exact expression of attenuation coefficient. Also, the parameters of coal and other factors affecting the electromagnetic wave propagation are analyzed and discussed. To further obtain more insights, the attenuation coefficient and skin depth of the very low-frequency (VLF) electromagnetic wave in coal medium with different degrees of metamorphism are studied, as well as the influence of resistivity. This provides scientific theoretical support for the application of VLF communication in coal mines. Finally, our theoretical analyses are verified by computer simulation, and the simulated numerical results show that: 1) The range of frequency of electromagnetic wave suitable for coal medium propagation is 3~3KHz (VLF); 2) The order of the electromagnetic waves attenuation coefficient in coal with different degrees of metamorphism is: anthracite> lignite > fat coal > coking coal > lean coal, and the order of skin depth is: lean coal > coking coal > fat coal> lignite > anthracite; 3) The resistivity of coal has little effect on the attenuation of electromagnetic wave when VLF is used for communication

Systematic Analysis of Survival-Associated Alternative Splicing Signatures in Thyroid Carcinoma

Alternative splicing (AS) is a key mechanism involved in regulating gene expression and is closely related to tumorigenesis. The incidence of thyroid cancer (THCA) has increased during the past decade, and the role of AS in THCA is still unclear. Here, we used TCGA and to generate AS maps in patients with THCA. Univariate analysis revealed 825 AS events related to the survival of THCA. Five prognostic models of AA, AD, AT, ES, and ME events were obtained through lasso and multivariate analyses, and the final prediction model was established by integrating all the AS events in the five prediction models. Kaplan–Meier survival analysis revealed that the overall survival rate of patients in the high-risk group was significantly shorter than that of patients in the low-risk group. The ROC results revealed that the prognostic capabilities of each model at 3, 5, and 8 years were all greater than 0.7, and the final prognostic capabilities of the models were all greater than 0.9. By reviewing other databases and utilizing qPCR, we verified the established THCA gene model. In addition, gene set enrichment analysis showed that abnormal AS events might play key roles in tumor development and progression of THCA by participating in changes in molecular structure, homeostasis of the cell environment and in cell energy. Finally, a splicing correlation network was established to reveal the potential regulatory patterns between the predicted splicing factors and AS event candidates. In summary, AS should be considered an important prognostic indicator of THCA. Our results will help to elucidate the underlying mechanism of AS in the process of THCA tumorigenesis and broaden the prognostic and clinical application of molecular targeted therapy for THCA

Research on the Audio Publishing of Classical Books Based on the Theory of Business Model Canvas: Taking Romance of the Three Kingdoms in Digital Audio Platforms as an Example

Visual media have dominated sensory communications for decades, and the resulting “visual hegemony” leads to the call for the “auditory return” in order to achieve a holistic balance in cultural acceptance. Romance of the Three Kingdoms, a classic literary work in China, has received significant attention and promotion from leading audio platforms. However, the commercialization of digital audio publishing faces unprecedented challenges due to the mismatch between the dissemination of long-form content on digital audio platforms and the current trend of short and fast information reception. Drawing on the Business Model Canvas Theory and taking Romance of the Three Kingdoms as the main focus of analysis, this paper argues that the construction of a business model for the audio publishing of classical books should start from three aspects: the user evaluation of digital audio platforms, the establishment of value propositions based on the “creative transformation and innovative development” principle, and the improvement of the audio publishing infrastructure to ensure the healthy operation and development of the digital audio platforms and consequently improve their current state of development and expand the boundaries of cultural heritage

The Spatiotemporal Evolution and Influencing Factors of the Chinese Cities’ Ecological Welfare Performance

In the “full world” where natural capital is scarce, within the limits of the ecological environment, the improvement of welfare is a fundamental requirement for sustainable development. The ecological wellbeing performance (EWP) of 284 cities in China from 2007 to 2020 was measured by the superefficient SBM-DEA model, considering undesirable output, and analyzing the evolutionary trends of overall comprehensive technical efficiency, pure technical efficiency, and scale efficiency. The Theil index was used to explore the source and distribution of the Chinese cities’ EWP differences. Exploratory spatial data analysis (ESDA) and the spatial Durbin model (SDM) were applied to analyze the spatial distribution characteristics and driving factors of cities’ EWP. The results showed the following: (1) Regarding spatial and temporal distribution, the EWP of Chinese cities showed a fluctuating upward trend, in which pure technical efficiency > scale efficiency. (2) Considering regional differences, the differences in cities’ EWP were mainly intraregional rather than interregional. The contribution rates of distinct regions to the differences in EWP varied, i.e., western region > eastern region > central region > northeastern region. (3) In terms of spatial correlation, China’s EWP showed positive spatial correlation, i.e., high–high agglomeration and low–low agglomeration. (4) Concerning influencing factors, the level of financial development, the structure of secondary industries, the level of opening-up, and the degree of urbanization significantly improved EWP. Decentralization of fiscal revenue significantly inhibited improvement of EWP. Decentralization of fiscal expenditure and technological progress had no significant impact on the EWP. In the future, to improve cities’ EWP, China should focus on reducing differences in intraregional EWP, overcoming administrative regional limitations, encouraging regions with similar locations to formulate coordinated development plans, promoting economic growth, reducing levels of environmental pollution, and paying attention to the improvement of social welfare

Migration Characteristics of Boring Mud in Roadway Floor Anchor Wire Hole and Test in Coal Mine

Given the difficulty in drilling the anchor holes in the roadway floor of the coal mine, the characteristics of slag movement in the process of positive and negative circulation drilling are analyzed. It is concluded that the interaction between the three zones of drilling and slag is the fundamental reason restricting the rapid drilling of the anchor cable hole in the floor, and it is proposed that the pump reverse circulation drilling can effectively prevent the formation of the three zones of drilling and slag. According to the actual situation, the relationship between drilling depth, vacuum degree of the pump, and the velocity of drilling fluid and the volume of drilling slag is obtained. The results show that the pump suction reverse circulation is feasible for the rapid drilling of the anchor hole of the floor. A set of pump suction reverse circulation drilling systems has been developed, and floor anchor wire hole drilling and slag discharge operation at the same time were realized. The field test shows that the effective drilling time of the anchor cable hole in the depth of 5.6 m can be controlled within 30 min, which solves the problem of deep hole drilling in the anchor hole of the bottom plate and purifies the working environment

Economic Growth Target, Government Expenditure Behavior, and Cities’ Ecological Efficiency—Evidence from 284 Cities in China

As a composite indicator that incorporates economic efficiency and environmental protection, ecological efficiency is a valuable tool for measuring regional green development and accelerating regional green transformation. As the economy transitions, Chinese economic growth targets affect local governments’ behaviors, thereby impacting ecological efficiency. In this study, the ecological efficiency level of 284 cities in China was measured using the EBM-DEA method from 2007 to 2019, and the spatial exploration analysis method and the dynamic double fixed effect spatial Durbin model were applied to analyze urban ecological efficiency’s spatial correlations, impacts, and mechanisms. The conclusions are as follows: China’s urban ecological efficiency has increased over time. At the spatial level, it shows the distribution characteristics of east > northeast > middle > west. In terms of spatial agglomeration, there are typically spatial agglomerations, high–high agglomerations, and low–low agglomerations in Chinese cities’ ecological efficiency. There is an inverted U-shaped relationship between economic growth target and ecological efficiency. According to regional differences, the economic growth target in the eastern region has a U-shaped impact on ecological efficiency, while in the central, northeast, and western cities they have an inverted U-shaped effect on ecological efficiency. In terms of the impact mechanism, through the intermediary effect test, it is found that appropriate economic growth target setting can promote the proportion of energy conservation and environmental protection expenditure and fiscal science and technology expenditure. Excessive economic growth target setting can inhibit the proportion of energy conservation and environmental protection expenditure and fiscal science and technology expenditure. The proportion of energy conservation and environmental protection expenditure and fiscal science and technology expenditure can promote ecological efficiency. The enlightenment is as follows: China should weaken the economic growth target in official promotion assessment, set differentiated economic growth targets for different regions, and increase the proportion of energy conservation and environmental protection expenditure and fiscal science and technology expenditure to promote ecological efficiency

Mesenchymal stem cell-derived extracellular vesicles prevent the formation of pulmonary arterial hypertension through a microRNA-200b-dependent mechanism

Abstract Background Bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) have been highly studied with their critical roles as carriers of therapeutic targets such as microRNAs (miRNAs) in the treatment of human diseases, including pulmonary arterial hypertension (PAH). Herein, we tried to study the potential of BMSC-EVs to deliver miR-200b for the regulation of macrophage polarization in PAH. Methods Rat models of PAH were induced with monocrotaline treatment, followed by miR-200b expression detection in lung tissues, pulmonary artery smooth muscle cells (PASMCs) and macrophages. miR-200b-containing BMSCs or miR-200b-deficient BMSCs were selected to extract EVs. Then, we assessed the changes in rats with PAH-associated disorders as well as in vitro macrophage polarization and the functions of PASMCs after treatment with BMSC-EVs. Moreover, the interaction between miR-200b, phosphodiesterase 1 A (PDE1A) was identified with a luciferase assay, followed by an exploration of the downstream pathway, cAMP-dependent protein kinase (PKA). Results miR-200b was reduced in lung tissues, PASMCs and macrophages of rats with PAH-like pathology. BMSC-EVs transferred miR-200b into macrophages, and subsequently accelerated their switch to the M2 phenotype and reversed the PAH-associated disorders. Furthermore, miR-200b carried by BMSC-EVs induced PKA phosphorylation by targeting PDE1A, thereby expediting macrophage polarization. Conclusion Our current study highlighted the inhibitory role of BMSC-EV-miR-200b in PAH formation

Can Local Government’s Attention Allocated to Green Innovation Improve the Green Innovation Efficiency?—Evidence from China

Green innovation is an important way to integrate China’s innovation-driven strategy with sustainable development strategy. Adopting the attention-based view in policy implementation analysis, this paper constructs an analytical framework of how the local government’s attention paid to green innovation (LGA-GI) affects green innovation efficiency (GIE). Using the panel data of 30 provincial administrative regions in China from 2009 to 2020, we describe the temporal and spatial characteristics of LGA-GI, empirically test the impact of LGA-GI on GIE through two-way fixed effects models, and then compare the effects in the three stages of green innovation. The major findings are as follows: (1) the LGA-GI in China from 2009 to 2020 shows an upward trend with mild fluctuations, and peaks three times in 2012, 2016, and 2018. The spatial distribution of LGA-GI has changed from a pattern of “low in the middle” (low LGA-GI in the central region) to “continuous highs with scattered lows”. (2) LGA-GI has a significant positive effect on the overall GIE, but the effect is concentrated in the stage of knowledge absorption and commercialization, rather than in the stage of knowledge innovation. The implication of these results is that local governments need to allocate more attention to green innovation and maintain its continuity, and governments at all levels should distribute policy implementation resources based on the characteristics of different green innovation stages