A Review of Treatment of Acute Ischemic Stroke

Treatment strategies for acute ischaemic stroke focus on two main areas: improving blood circulation to the brain and neuropro-tection. However, these measures are only efective in the treatment of vascular stenoses. However, they are only efective within a narrow therapeutic window and are therefore limited. This article now provides a brief summary of the clinical treatment of acute ischaemic stroke and its future directions, with the aim of providing an updated direction and theoretical basis for relevant drug development

THE EFFECT OF RUNNING ECONOMY IN MALE RUNNERS WEARING 3 TYPES OF FOOTWEAR

The purpose of this study was to identify the effect of running economy in male runners wearing Nike ZoomX Vaporfly Next%2(N), Qiaodan Feiying pb2(Q), and Xtep2(X) footwear. Twelve male middle-caliber runners (mean±SD, age: 21.0±2.0year, maximum oxygen uptake (VO2max): 51.2±3.7ml/kg/min) attended 4 sessions. The first session consisted of a VO2max test to inform subsequent RE speeds set at 60%, 70%, and 80% of the speed eliciting VO2max (ʋVO2max). In subsequent sessions, treadmill RE was assessed in the 3 footwear conditions in a randomized, counterbalanced crossover design. Oxygen consumption (ml/kg/min) and energy expenditure (W/kg) was lesser in Q vs. X at 80% of ʋVO2max, and there had a significant difference between Q、N and X (p2max (p\u3e0.05). Overall, Qiaodan Feiying pb2 improved RE and energy expenditure in middle-caliber male runners at 80% of ʋVO2max compared to Xtep2, but these improvements had no differences among the 3 types of footwear at 60% and 70% of ʋVO2max

ChinaTelecom System Description to VoxCeleb Speaker Recognition Challenge 2023

This technical report describes ChinaTelecom system for Track 1 (closed) of the VoxCeleb2023 Speaker Recognition Challenge (VoxSRC 2023). Our system consists of several ResNet variants trained only on VoxCeleb2, which were fused for better performance later. Score calibration was also applied for each variant and the fused system. The final submission achieved minDCF of 0.1066 and EER of 1.980%.Comment: System description of VoxSRC 202

Thermal Boundary Conductance Across Metal-Nonmetal Interfaces: Effects of Electron-Phonon Coupling both in Metal and at Interface

We theoretically investigate the thermal boundary conductance across metal-nonmetal interfaces in the presence of the electron-phonon coupling not only in metal but also at interface. The thermal energy can be transferred from metal to nonmetal via three channels: (1) the phonon-phonon coupling at interface; (2) the electron-phonon coupling at interface; and (3) the electron-phonon coupling within metal and then subsequently the phonon-phonon coupling at interface. We find that these three channels can be described by an equivalent series-parallel thermal resistor network, based on which we derive out the analytic expression of the thermal boundary conductance. We then exemplify different contributions from each channel to the thermal boundary conductance in three typical interfaces: Pb-diamond, Ti-diamond, and TiN-MgO. Our results reveal that the competition among above channels determines the thermal boundary conductance.Comment: 17 pages, 2 figure

Spin Seebeck Effect in Asymmetric Four-Terminal Systems with Rashba Spin-Orbit Coupling

We propose a new type of the spin Seebeck effect (SSE) emerging from the Rashba spin-orbit coupling in asymmetric four-terminal electron systems. This system generates spin currents or spin voltages along the longitudinal direction parallel to the temperature gradient in the absence of magnetic fields. The remarkable result arises from the breaking of reflection symmetry along the transverse direction. In the meantime, the SSE along the transverse direction, so-called the spin Nernst effect, with spin currents or spin voltages perpendicular to the temperature gradient can be simultaneously realized in our system. We further find that it is possible to use the temperature differences between four leads to tune the spin Seebeck coefficients.Comment: 14 pages, 4 figure

Gap between words and action: empirical study on the consistency of farmers supporting green vegetable production practices

The increasing interest on the quality and safety of vegetables has focused much attention to the words (willingness) and action (behavior) of farmers toward the production of safe vegetables. However, the majority of studies typically focus on willingness or behavior, ignoring the interactions between the two. Moreover, there exists a wide gap between farmers’ actual behavior and their willingness to support green production practices of vegetable. Thus, in order to explore the key factors of farmers’ willingness, behavior, and their consistency to adopt green vegetable production vegetable practices, we performed bivariate probit modeling and binary logistic regression based on a survey of 452 farmers in Beijing, China. Results demonstrate the number of farmers willing to adopt green vegetable production practices to exceed those who do not by 65.5%. In particular, 73.9% of farmers adopt green vegetable production practices, while 67.5% of farmers exhibit an adoption willingness that is consistent with the adoption behavior. A positive correlation is observed between the willingness and behavior to adopt green production practices of vegetable, while the key influencing factors of the willingness, behavior, and consistency of green production practices are distinct. For example, cooperatives, neighboring farmers, and government regulation exert a significant positive impact on consistency, while family labor force, vegetable income, and the media have a significant negative impact. Moreover, cooperatives are identified as the most important influencing factor. Our work offers guidance in understanding the influencing factors of the willingness and behavior to adopt green vegetable production practices, and can provide a policy basis for governments to promote such practices

The relationship between gut microbiota and inflammatory response, learning and memory in mice by sleep deprivation

ObjectiveSleep deprivation has developed into a common phenomenon, which can lead to inflammatory responses and cognitive impairment, but the underlying mechanism is ambiguous. Emerging evidence shows that gut microbiota plays a crucial role in theoccurrence and development of inflammatory and psychiatric diseases, possibly through neuroinflammation and the brain-gut axis. The current study investigated the influence of sleep deprivation on gut microbiota composition, pro-inflammatory cytokines, learning and memory in mice. Further, it explored whether changes in gut microbiota increase pro-inflammatory cytokine and induce learning and memory impairment.MethodsHealthy 8-week-old male C57BL/6J mice were randomly divided into the regular control group (RC), environmental control group (EC), and sleep deprivation group (SD). The sleep deprivation model was established by the Modified Multiple Platform Method. The experimental mice were subjected to sleep deprivation for 6h/d (8:00 am∼14:00 pm) in a sleep deprivation chamber, and the duration of sleep deprivation was 8 weeks. Morris water maze test to assess learning and memory in mice. Enzyme-Linked Immunosorbent Assay determined the concentrations of inflammatory cytokines. The changes in gut microbiota in mice were analyzed by 16S rRNA sequencing.ResultsWe found that SD mice had elevated latency of exploration to reach the hidden platform (p>0.05) and significantly decreased traversing times, swimming distance, and swimming time in the target zone when the hidden platform was removed (p<0.05). Sleep deprivation caused dysregulated expression in serum IL-1β, IL-6, and TNF-α in mice, and the difference was significant (all p<0.001). Tannerellaceae, Rhodospirillales, Alistipes, and Parabacteroides were significantly increased in SD mice. Correlation analysis showed IL-1β was positively correlated with the abundance of Muribaculaceae (r=0.497, p<0.05) and negatively correlated with the abundance of Lachnospiraceae (r=-0.583, p<0.05). The TNF-α was positively correlated with the abundances of Erysipelotrichaceae, Burkholderiaceae, and Tannerellaceae (r=0.492, r=0.646, r=0.726, all p<0.05).ConclusionSleep deprivation can increase pro-inflammatory cytokine responses and learning and memory impairment in mice and may be caused by the disorder of the microbiota. These findings of this study may open avenues for potential interventions that can relieve the detrimental consequences of sleep loss