1 research outputs found
Nitrogen and Phosphorus Co-Doped Carbon Nanodots as a Novel Fluorescent Probe for Highly Sensitive Detection of Fe<sup>3+</sup> in Human Serum and Living Cells
Chemical doping with heteroatoms
can effectively modulate physicochemical
and photochemical properties of carbon dots (CDs). However, the development
of multi heteroatoms codoped carbon nanodots is still in its early
stage. In this work, a facile hydrothermal synthesis strategy was
applied to synthesize multi heteroatoms (nitrogen and phosphorus)
codoped carbon nanodots (N,P-CDs) using glucose as carbon source,
and ammonia, phosphoric acid as dopant, respectively. Compared with
CDs, the multi heteroatoms doped CDs resulted in dramatic improvement
in the electronic characteristics and surface chemical activities.
Therefore, the N,P-CDs prepared as described above exhibited a strong
blue emission and a sensitive response to Fe<sup>3+</sup>. The N,P-CDs
based fluorescent sensor was then applied to sensitively determine
Fe<sup>3+</sup> with a detection limit of 1.8 nM. Notably, the prepared
N,P-CDs possessed negligible cytotoxicity, excellent biocompatibility,
and high photostability. It was also applied for label-free detection
of Fe<sup>3+</sup> in complex biological samples and the fluorescence
imaging of intracellular Fe<sup>3+</sup>, which indicated its potential
applications in clinical diagnosis and other biologically related
study