A novel tension monitoring device of multi-rope friction hoister by using acoustic filtering sensor

Wire rope tension is one of the vital monitoring parameters for the hoister system, which seriously influence mine coal safety production. However, wire ropes endure vibration and shock in lifting process of multi-rope friction hoisters in coal mine, which interferes with measurement of wire rope tension and lifting load seriously. Aimed to the difficulty of monitoring wire rope tension, this paper put forward a new measurement method of wire rope tension by transferring wire rope tension measurement to pressure measurement, which improves the measurement safety and avoids the safety hazards of adopting pull sensor in series with wire rope, and this paper also designed an acoustic filtering sensor which uses the filtering characteristic of acoustic cavity to eliminate the effect of vibration and shock in wire rope tension measurement. Meanwhile, a novel wire rope tension monitoring device of multi-rope friction hoister is presented based on the proposed measurement method and sensor, which can measure each wire rope tension in the lifting process, display the cage load and monitor the fault of wire rope tension unbalance. Real-time and accurate wire rope tension measurement is realized. By comparing the signals measured by the common sensor and the acoustic filtering sensor, the influence of vibration and shock on the multi-ropes tension measurement is eliminated, and the fault of wire rope tension unbalance can be monitored. This advanced tension monitoring device is of great significance to the safety of coal mine production

Land Contamination and Brownfield Management Policy Development in China: Learning from the UK Experience

Ming Liu (Department of Science, Technology & Innovation, British Consulate-General Guangzhou), Xia Yang (Administrative Centre for China’s Agenda21) and Paul Wills (UK Trade & Investment) helped discussion and revision of the report. Diogo Gomes (Cranfield University) also provided support for the graphical arts and assisted with the editing. The authors are grateful to all partners of the SPF project which include a wide team of collaborators and advisors across China and UK for their useful discussions and contribution during the two workshops organised during the project. Government, Academia, Industry and Public bodies have been collaborating together to drive structural changes far beyond the scope of a single organisation.Over the last 30 years, China’s fast urbanisation along with huge expansion of its manufacturing industry has led to the emergence of significant soil and water contamination problems across China. In the meantime, a number of policies and regulatory agencies for the protection of the environment have been implemented to stop deliberate pollution and more recently to address pollution prevention at source on a wider scale. Soil protection and management have been featured in policy discussions since the late 1950s in China. However, the topic has recently been of greatly expanded interest in the development of emerging policies, particularly with regards to the role of soil as a resource, independent of the functions that it carries out. Soil provides multiple important functions such as provision of food and raw materials, a platform for urban development and human wellbeing and a filtering and transforming media for water, nutrients, and carbon. However as pointed out by Yuan Si, Deputy Director of the Environmental Protection and Resources Conservation Committee of the National People Congress (China Daily, 11 March 2016), the move toward integrated management that has been driving policies for air and water has proven to be a challenge for soil management, mainly due to the multiple functions that soils provide. This is also true internationally and explained by several drivers for soil protection including among others soil contamination, construction, agriculture and amenity value.Foreign and Commonwealth Office’s Prosperity Fund programme - China Prosperity Strategic Programme Fund (SPF) 15SU3

Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer

Abstract Mitochondria are energy factories of cells and are important pivots for intracellular interactions with other organelles. They interact with the endoplasmic reticulum, peroxisomes, and nucleus through signal transduction, vesicle transport, and membrane contact sites to regulate energy metabolism, biosynthesis, immune response, and cell turnover. However, when the communication between organelles fails and the mitochondria are dysfunctional, it may induce tumorigenesis. In this review, we elaborate on how mitochondria interact with the endoplasmic reticulum, peroxisomes, and cell nuclei, as well as the relation between organelle communication and tumor development

Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities

Abstract c-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming gene) family, and is expressed on the surfaces of various cells. Hepatocyte growth factor (HGF) is the ligand for this receptor. The binding of HGF to c-Met initiates a series of intracellular signals that mediate embryogenesis and wound healing in normal cells. However, in cancer cells, aberrant HGF/c-Met axis activation, which is closely related to c-Met gene mutations, overexpression, and amplification, promotes tumor development and progression by stimulating the PI3K/AKT, Ras/MAPK, JAK/STAT, SRC, Wnt/β-catenin, and other signaling pathways. Thus, c-Met and its associated signaling pathways are clinically important therapeutic targets. In this review, we elaborate on the molecular structure of c-Met and HGF and the mechanism through which their interaction activates the PI3K/AKT, Ras/MAPK, and Wnt signaling pathways. We also summarize the connection between c-Met and RON and EGFR, which are also receptor tyrosine kinases. Finally, we introduce the current therapeutic drugs that target c-Met in primary tumors, and their use in clinical research