54 research outputs found
Isoquinoline and quinazoline urea analogues as antagonists for the Human Adenosine A3 receptor
Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)-and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine.
Various approaches to the synthesis of all four stereoisomers of 2-(1H- imidazol-4-yl)cyclopropylamine (cyclopropylhistamine) are described. The rapid and convenient synthesis and resolution of trans-cyclopropylhistamine is reported. The absolute configuration of its enantiomers was determined by single-crystal X-ray crystallographic analysis. The distinct transcyclopropylhistamine enantiomers were tested for their activity and affinity on the histamine
Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor
Homologs of histamine as histamine H₃ receptor antagonists: a new potent and selective H₃ antagonist, 4(5)-(5-aminopentyl)-1H-imidazole.
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