Spatializing the Corridor

The goal of this thesis project is to develop a model for a public corridor that would serve as the basis for the future development in the planning of a new district

SCUT-FBP5500: A Diverse Benchmark Dataset for Multi-Paradigm Facial Beauty Prediction

Facial beauty prediction (FBP) is a significant visual recognition problem to make assessment of facial attractiveness that is consistent to human perception. To tackle this problem, various data-driven models, especially state-of-the-art deep learning techniques, were introduced, and benchmark dataset become one of the essential elements to achieve FBP. Previous works have formulated the recognition of facial beauty as a specific supervised learning problem of classification, regression or ranking, which indicates that FBP is intrinsically a computation problem with multiple paradigms. However, most of FBP benchmark datasets were built under specific computation constrains, which limits the performance and flexibility of the computational model trained on the dataset. In this paper, we argue that FBP is a multi-paradigm computation problem, and propose a new diverse benchmark dataset, called SCUT-FBP5500, to achieve multi-paradigm facial beauty prediction. The SCUT-FBP5500 dataset has totally 5500 frontal faces with diverse properties (male/female, Asian/Caucasian, ages) and diverse labels (face landmarks, beauty scores within [1,~5], beauty score distribution), which allows different computational models with different FBP paradigms, such as appearance-based/shape-based facial beauty classification/regression model for male/female of Asian/Caucasian. We evaluated the SCUT-FBP5500 dataset for FBP using different combinations of feature and predictor, and various deep learning methods. The results indicates the improvement of FBP and the potential applications based on the SCUT-FBP5500.Comment: 6 pages, 14 figures, conference pape

An Inquiry into the Evolution of the Project-based Instructional Approach “Three” from “A Program” to “A High-quality Course”

Within the context of education reform, there is a pressing need to overhaul and enhance the existing educational approach. As part of this endeavor, it is imperative to establish a more adaptable and multifaceted project-based teaching methodology. However, it is important to acknowledge that this approach also exhibits certain inherent limits, which become increasingly apparent during its implementation. However, it is worth considering if this particular pedagogical approach can effectively address its inherent limits and successfully facilitate the desired transformation and advancement of the educational system. This research aims to examine the efficacy of the “three” teaching approach in facilitating the transition from a mere instructional plan to an effective classroom experience

Assessing sustainability performance of high-tech firms through a hybrid approach

Purpose: In light of the lack of subjective criteria and scientific rationality in current sustainability performance assessment, the purpose of this paper is conducted to improve the sustainability performance assessment of high-tech firms by developing a hybrid approach that integrates quantitative and qualitative research methods. Design/methodology/approach: This study proposed a hybrid approach that integrates word frequency analysis, cluster analysis, grey theory and the decision-making and trial evaluation laboratory (DEMATEL) method. Specifically, this study identifies useful criteria using quantitative word frequency analysis as well as qualitative literature research. Then, cluster analysis is used to divide these criteria into different categories. Subsequently, this study applies the grey theory associated with the DEMATEL method to assess the sustainability performance of high-tech firms. Findings: The results reveal that the socio-environment is an important aspect underlying the corporate sustainability performance of high-tech firms. Therefore, high-tech firms should enhance their pollution emission control capabilities and increase investment in energy-conservation and emission-reduction technologies to drive sustainable development. In addition, increasing green product sales revenue and improving the guiding capability of green consumption are core issues that firms must address. Originality/value: This study assesses the sustainability performance of high-tech firms by applying a hybrid method. This method can be used to construct a framework for scientific sustainability performance assessment and to provide a clear direction for the sustainable development of firms

Selective Water Transport in an Alanine-Functionalized Metal–Organic Framework: A Computational Study

Applications of metal–organic frameworks (MOFs) functionalized with biomolecules have primarily focused on the use of these frameworks for bioimaging, catalysis, chiral separation, nanomotors, and drug delivery. However, their use in the design of artificial water channels (AWCs) has yet to be explored. In this work, we computationally explore the performance of a zwitterionic alanine-functionalized Ni-CPO-27 MOF as an AWC. Using density functional theory (DFT) calculations and equilibrium/nonequilibrium molecular dynamics (MD) simulations, the stability, water permeability, and ion selectivity of the proposed AWC are studied. The DFT calculations predict that zwitterionic alanine binds to the coordinatively unsaturated Ni sites almost twofold stronger compared to water. Using the quantum theory of atoms in molecules, it is also found that the zwitterionic alanine molecules are further stabilized through hydrogen bonding between their carboxylate (COO–) and amino (NH3+) groups. Nonequilibrium MD simulations show that the proposed AWC possesses a high osmotic water permeability of 2.2 ± 0.3 × 10–15 cm3/s/channel, which lies between that observed in aquaporin-0 and aquaporin-1 proteins, while completely excluding Na+ and Cl– ions from the channel. The free energies associated with the water and ion transport show that fast water transport may be attributed to the relatively low free energy barriers for water in the channel, whereas the ion exclusion is due to large free energy barriers that the ions cannot overcome even under 100 MPa of applied pressure. By using a crystalline material, the proposed design of an amino acid-functionalized MOF-based AWC represents a departure from previously developed AWCs, which rely on the self-assembly of curated molecules in lipid bilayers or polymer matrices and are susceptible to long-term stability issues

Antitussive efficacy of the current treatment protocol for refractory chronic cough: our real-world experience in a retrospective cohort study

BACKGROUND: The management of refractory chronic cough (RCC) is a great challenge. Neuromodulators have long been used for RCC with imperfect efficacy. OBJECTIVES: We summarized the outcomes of the current treatments used at our specialist cough clinic, which provides a guideline-led service and real-world experience for the future management of RCC. DESIGN: This is a single-centre retrospective observational cohort study. METHODS: Consecutive RCC patients (the first clinic visit between January 2016 and May 2021) were included into this observational cohort study. Medical records in the Chronic Cough Clinical Research Database were fully reviewed using uniform criteria. The included subjects were followed-up for at least 6 months after the final clinic visit via instant messages with the link to self-scaled cough-associated questionnaires. RESULTS: Overall, 369 RCC patients were analysed with a median age of 46.6 years and a cough duration of 24.0 months. A total of 10 different treatments were offered. However, 96.2% of patients had been prescribed at least one neuromodulator. One-third of patients had alternative treatments prescribed given the poor response to the initial therapy and 71.3% favourably responded to at least one of the treatments. Gabapentin, deanxit, and baclofen had comparable therapeutic efficacy (56.0%, 56.0%, and 62.5% respectively; p = 0.88) and overall incidences of adverse effects (28.3%, 22.0%, and 32.3% respectively; p = 0.76). However, 19.1 (7.7-41.8) months after the last clinic visit, 65.0% reported improvement (24.9%) or control of their cough (40.1%); 3.8% reported a spontaneous remission and 31.2% still had a severe cough. Both HARQ (n = 97; p < 0.001) and LCQ (n = 58; p < 0.001) demonstrated marked improvement. CONCLUSION: Trying different neuromodulators is a pragmatic strategy for RCC, which helped around two-thirds of patients. Relapse is common on withdrawal or reduction of dosage. Novel medication for RCC is an urgent clinical need. PLAIN LANGUAGE SUMMARY: This is the first report that fully represented a guideline-led treatment protocol for refractory chronic cough (RCC) based on a large series of patients, which evaluated the short- and long-term effects of the currently available treatments for RCC. We found that the therapeutic trial of different neuromodulators is a pragmatic strategy, which helped around two-thirds of patients. Gabapentin, deanxit (flupentixol/melitracen), and baclofen had similar therapeutic outcomes. This study may offer real-world experience for the future management of RCC

miRNA-378 reverses chemoresistance to cisplatin in lung adenocarcinoma cells by targeting secreted clusterin

Cisplatin resistance is a major obstacle in the treatment of NSCLC, and its mechanism has not been fully elucidated. The objectives of the study were to determine the role of miR-378 in the sensitivity of lung adenocarcinoma cells to cisplatin (cDDP) and its working mechanism. With TargetScan and luciferase assay, miR-378 was found to directly target sCLU. miR-378 and sCLU were regulated in A549/cDDP and Anip973/cDDP cells to investigate the effect of miR-378 on the sensitivity and apoptotic effects of cDDP. The effect of miR-378 upregulation on tumor growth was analyzed in a nude mouse xenograft model. The correlation between miR-378 and chemoresistance was tested in patient samples. We found that upregulation of miR-378 in A549/cDDP and Anip973/cDDP cells significantly down-regulated sCLU expression, and sensitized these cells to cDDP. miR-378 overexpression inhibited tumor growth and sCLU expression in a xenograft animal model. Analysis of human lung adenocarcinoma tissues revealed that the cDDP sensitive group expressed higher levels of miR-378 and lower levels of sCLU. miR-378 and sCLU were negatively correlated. To conclude, we identified sCLU as a novel miR-378 target, and we showed that targeting sCLU via miR-378 may help disable the chemoresistance against cisplatin in lung adenocarcinoma cells

The difference of affect improvement effect of music intervention in aerobic exercise at different time periods

Objectives: A randomized controlled experimental design that combines exercise and music intervention was adopted in this study to verify whether this approach could help improve human affect. The differences in the effect of music listening on affective improvement were compared in four different periods: before, during, and after aerobic power cycling exercise and the whole exercise course.Method: A total of 140 subjects aged 19–30 years (average age: 23.6 years) were recruited and randomly divided into four music intervention groups, namely, the pre-exercise, during-exercise, post-exercise, and the whole-course groups. The subjects’ demographic and sociological variables and daily physical activities were collected using questionnaires. Individual factors, such as the subjects’ noise sensitivity, personality traits, and degree of learning burnout, were collected via scale scoring. A laboratory in Zhejiang Normal University was selected as the experimental site. The testing procedure can be summarized as follows. In a quiet environment, the subjects were asked to sit quietly for 5 min after completing a preparation work, and then they were informed to take a pre-test. The four subject groups wore headphones and completed 20 min of aerobic cycling (i.e., 7 min of moderate-intensity cycling [50%*HRR + RHR] + 6 min of low-intensity interval cycling [30%*HRR + RHR] + 7 min of moderate-intensity cycling [50%*HRR + RHR] after returning to a calm state (no less than 20 min) for post-testing. The affect improvement indicators (dependent variables) collected in the field included blood pressure (BP), positive/negative affect, and heart rate variability indicators (RMSSD, SDNN, and LF/HF).Results: 1) Significant differences were found in the participants’ systolic BP (SBP) indices and the effect of improvement of the positive affect during the exercise–music intervention among the four groups at different durations for the same exercise intensity (F = 2.379, p = 0.030, ɳp2 = 0.058; F = 2.451, p = 0.043, ɳp2 = 0.091). 2) Music intervention for individuals during exercise contribute more to the reduction of SBP than the other three time periods (F = 3.170, p = 0.047, ɳp2 = 0.068). Improvement in the participants’ negativity affective score was also better during exercise, and it was significantly different than the other three time periods (F = 5.516, p = 0.006, ɳp2 = 0.113). No significant differences were found in the improvement effects of the other effective indicators for the four periods.Conclusion: Exercise combined with music intervention has a facilitative effect on human affect improvement, and listening to music during exercise has a better impact on affective improvement than music interventions at the other periods. When people perform physical activities, listening to music during exercise positively affects the progress effect among them