1-[6-(9H-Carbazol-9-yl)hex­yl]-2-phenyl-1H-benzimidazole

The mol­ecule of the title compound, C31H29N3, contains a hexyl chain, a coordination unit (benzimidazole) and a functional group (carbazole). The benzimidazole ring is not coplanar with either the phenyl ring or the carbazole system, making dihedral angles of 43.26 (3) and 39.03 (2)°, respectively. The dihedral angle between the phenyl ring and the carbazole system is 24.42 (3)°. The hexyl Cβ atom (with respect to benzimidazole) deviates by 1.124 (2) Å from the benzimidazole plane, although the Cα atom lies in the plane. The hexyl Cβ atom (with respect to carbazole) deviates by 1.315 (1) Å from the carbazole plane, although the Cα atom lies in the plane. The crystal structure is stabilized by inter­molecular C—H⋯π inter­actions

A FRACTURE-INDUCED ADHESIVE WEAR CRITERION AND ITS APPLICATION TO THE SIMULATION OF WEAR PROCESS OF THE POINT CONTACTS UNDER MIXED LUBRICATION CONDITION

Adhesive wear is one of the four major wear mechanisms and very common in almost all macro-, micro- or nanotribosystems. In an adhesive wear process, tiny material fragments are pulled off from one sliding surface and adhered onto the counterpart. Later these fragments form loose particles or transfer between the contact surfaces. Because of the topographical and physicochemical property non-uniformity of engineering surfaces, adhesive wear happens heterogeneously on the loaded sliding surfaces, and it is also discontinuous during sliding or rolling motion owing to the damage accumulation and fracture occurred inside the subsurface layers. Taking account of these characteristics, a novel fracture-induced adhesive wear criterion has been proposed in this study in order to predict local wear of material in sliding. Moreover, the proposed wear criterion is applied to predicting wear particle formation and morphology evolution of mixed lubricated rough surfaces during reciprocating sliding, and the simulation results are compared with the ball-on-disk experimental measurements

Src-family protein tyrosine kinases: a promising target for treating chronic pain

Abstract Despite growing knowledge of the mechanisms of chronic pain, it remains a major challenge facing clinical practice. Src-family protein tyrosine kinases (SFKs), a group of non-receptor protein tyrosine kinases, have been implicated in neuronal development and synaptic plasticity. SFKs are critically central to various transmembrane receptors e.g. G-protein coupled receptor (GPCR), EphB receptor (EphBR), increased intracellular calcium, epidermal growth factor (EGF) and other growth factors that regulate the phosphorylation of N-methyl-D-aspartic acid receptor (NMDAR) 2B subunit, thus contributing to the development of chronic pain. SFKs have also been regarded as an important point of convergence of intracellular signaling components that regulate microglia functions and the immune response. Additionally, intrathecal administration of SFKs inhibitors significantly alleviates mechanical allodynia in different chronic pain models. Thus, here we reviewed the current evidence of the role of SFKs in the development of chronic pain caused by complete Freund's adjuvant (CFA) injection, peripheral nerve injury (PNI), streptozotocin (STZ) injection and bone metastasis. Moreover, the role of SFKs on the development of morphine tolerance has also been discussed. Management of SFKs therefore emerged as a potential therapeutic target for the treatment of chronic pain in terms of safety and efficacy. Key words Chronic pain; Src-family protein tyrosine kinases; N-methyl-D-aspartic acid receptor; Microglia