A Hybrid Continuity Loss to Reduce Over-Suppression for Time-domain Target Speaker Extraction

Speaker extraction algorithm extracts the target speech from a mixture speech containing interference speech and background noise. The extraction process sometimes over-suppresses the extracted target speech, which not only creates artifacts during listening but also harms the performance of downstream automatic speech recognition algorithms. We propose a hybrid continuity loss function for time-domain speaker extraction algorithms to settle the over-suppression problem. On top of the waveform-level loss used for superior signal quality, i.e., SI-SDR, we introduce a multi-resolution delta spectrum loss in the frequency-domain, to ensure the continuity of an extracted speech signal, thus alleviating the over-suppression. We examine the hybrid continuity loss function using a time-domain audio-visual speaker extraction algorithm on the YouTube LRS2-BBC dataset. Experimental results show that the proposed loss function reduces the over-suppression and improves the word error rate of speech recognition on both clean and noisy two-speakers mixtures, without harming the reconstructed speech quality.Comment: Submitted to Interspeech202

EMT-related gene classifications predict the prognosis, immune infiltration, and therapeutic response of osteosarcoma

BackgroundOsteosarcoma (OS), a bone tumor with high ability of invasion and metastasis, has seriously affected the health of children and adolescents. Many studies have suggested a connection between OS and the epithelial-mesenchymal transition (EMT). We aimed to integrate EMT-Related genes (EMT-RGs) to predict the prognosis, immune infiltration, and therapeutic response of patients with OS.MethodsWe used consensus clustering to identify potential EMT-Related OS molecular subtypes. Somatic mutation, tumor immune microenvironment, and functional enrichment analyses were performed for each subtype. We next constructed an EMT-Related risk signature and evaluated it by Kaplan-Meier (K-M) analysis survival and receiver operating characteristic (ROC) curves. Moreover, we constructed a nomogram to more accurately predict OS patients’ clinical outcomes. Response effects of immunotherapy in OS patients was analyzed by Tumor Immune Dysfunction and Exclusion (TIDE) analysis, while sensitivity for chemotherapeutic agents was analyzed using oncoPredict. Finally, the expression patterns of hub genes were investigated by single-cell RNA sequencing (scRNA-seq) data analysis.ResultsA total of 53 EMT-RDGs related to prognosis were identified, separating OS samples into two separate subgroups. The EMT-high subgroup showed favourable overall survival and more active immune response. Significant correlations were found between EMT-Related DEGs and functions as well as pathways linked to the development of OS. Additionally, a risk signature was established and OS patients were divided into two categories based on the risk scores. The signature presented a good predictive performance and could be recognized as an independent predictive factor for OS. Furthermore, patients with higher risk scores exhibited better sensitivity for five drugs, while no significant difference existed in immunotherapy response between the two risk subgroups. scRNA-seq data analysis displayed different expression patterns of the hub genes.ConclusionWe developed a novel EMT-Related risk signature that can be considered as an independent predictor for OS, which may help improve clinical outcome prediction and guide personalized treatments for patients with OS

Comparative Study of In-situ Test and Laboratory Test on Material Reflectivity

AbstractThis paper gives the theory algorithm of material reflectivity, and works out the in-situ material reflectivity combined with in-situ conditions, researches the influence rules of material's reflectivity under practical solar radiation intensity, and the feasibility of this simple in-situ test method is researched by the comparison of in-situ test result and laboratory test result

InterFace:Adjustable Angular Margin Inter-class Loss for Deep Face Recognition

In the field of face recognition, it is always a hot research topic to improve the loss solution to make the face features extracted by the network have greater discriminative power. Research works in recent years has improved the discriminative power of the face model by normalizing softmax to the cosine space step by step and then adding a fixed penalty margin to reduce the intra-class distance to increase the inter-class distance. Although a great deal of previous work has been done to optimize the boundary penalty to improve the discriminative power of the model, adding a fixed margin penalty to the depth feature and the corresponding weight is not consistent with the pattern of data in the real scenario. To address this issue, in this paper, we propose a novel loss function, InterFace, releasing the constraint of adding a margin penalty only between the depth feature and the corresponding weight to push the separability of classes by adding corresponding margin penalties between the depth features and all weights. To illustrate the advantages of InterFace over a fixed penalty margin, we explained geometrically and comparisons on a set of mainstream benchmarks. From a wider perspective, our InterFace has advanced the state-of-the-art face recognition performance on five out of thirteen mainstream benchmarks. All training codes, pre-trained models, and training logs, are publicly released \footnote{$https://github.com/iamsangmeng/InterFace$}.Comment: arXiv admin note: text overlap with arXiv:2109.09416 by other author