Chronic Inflammation Connects the Development of Parkinson’s Disease and Cancer

Increasing number of genetic studies suggest that the pathogenesis of Parkinson’s disease (PD) and cancer may involve similar genes, pathways, and mechanisms. The differences in the pathological and cellular mechanisms, and the associated genetic mutations, may result in two such divergent diseases. However, the links between the molecular mechanisms that cause PD and cancer remain to be elucidated. This article appraises the overlapping molecular features of these diseases and discusses the implications for prevention and treatment. We propose that chronic inflammation (CI) in neurons and tumors contributes to a microenvironment that favors the amassing of DNA mutations and facilitating disease formation. CI may therefore play a key role in the development of PD and cancer, and provide a link between these two diseases

Aqua­(hexa­methyl­enetetra­mine-κN)bis­(methanol-κO)bis­(thio­cyanato-κN)cobalt(II)

In the title complex, [Co(NCS)2(C6H12N4)(CH4O)2(H2O)], the six-coordinated Co atom has a slightly distorted octa­hedral geometry. The molecules are linked by intermolecular O—H⋯S and O—H⋯N hydrogen bonds, forming a three- dimensional crystal structure. Intramolecular C—H⋯N and C—H⋯O hydrogen bonds are also present

Quadruple bonding between iron and boron in the BFe(CO)3- complex.

While main group elements have four valence orbitals accessible for bonding, quadruple bonding to main group elements is extremely rare. Here we report that main group element boron is able to form quadruple bonding interactions with iron in the BFe(CO)3- anion complex, which has been revealed by quantum chemical investigation and identified by mass-selected infrared photodissociation spectroscopy in the gas phase. The complex is characterized to have a B-Fe(CO)3- structure of C3v symmetry and features a B-Fe bond distance that is much shorter than that expected for a triple bond. Various chemical bonding analyses indicate that the complex involves unprecedented B≣Fe quadruple bonding interactions. Besides the common one electron-sharing σ bond and two Fe→B dative π bonds, there is an additional weak B→Fe dative σ bonding interaction. This finding of the new quadruple bonding indicates that there might exist a wide range of boron-metal complexes that contain such high multiplicity of chemical bonds

The Development of a Portable ECG Monitor Based on DSP

AbstractWith the advent of global information, researches of Smart Home system are in the ascendant, the ECG real-time detection, and wireless transmission of ECG become more useful. In order to achieve the purpose we developed a portable ECG monitor which achieves the purpose of cardiac disease remote monitoring, and will be used in the physical and psychological disease surveillance in smart home system, we developed this portable ECG Monitor, based on the analysis of existing ECG Monitor, using TMS320F2812 as the core controller, which complete the signal collection, storage, processing, waveform display and transmission

Short- And Long-Term Value-At-Risk, Skewness, Kurtosis and Coherent Risk Measure

Standard risk management focuses on short-run risks rather than longer periods. We introduce an improved risk measure which can be used to estimate both short-and long-term structure of value at risk and the corresponding expected shortfall. The short- and long-term coherent measure of risk is specified and computed for both S&P 500, HSI and SHSZ 300. We also test long-term skewness and kurtosis from empirical analysis for S&P 500, HSI and SHSZ 300. We also show that our improved risk measure gives a better estimate of the value at risk for short horizons and never decreases to negative values like VaR for long-run horizons. Both long-term skewness and kurtosis for HSI and SHSZ 300 are analyzed empirically