Syntheses, Structures, and Characteristics of Three Metal Complexes Constructed Using Hexacarboxylic Acid

In this study, three new 3D coordination polymers (CPs), {[Cd3(L)(H2O)6]·H2O}n (1), {[Cu1.5(L)0.5(bimb)1.5]·5H2O·DMF}n (2), and {[Mn1.5(H3L)(bibp)0.5(H2O)2]·3H2O}n (3) (bimb= 1,3-bis(imidazol-1-yl)benzene, bibp= 1,4-bis((4-imidazol-1-yl)benzyl)piperazine), were prepared under solvothermal or hydrothermal conditions based on a hexadentate ligand (1,3,5-triazine-2,4,6-triamine hexa-acetic acid (H6L)). Structural elucidations were carried out by IR spectra along with single-crystal X-ray diffraction analysis, while thermogravimetric analysis (TGA) (dynamic and isothermal) and XRD techniques were used for property evaluations of the polymers. Furthermore, the fluorescence properties and detection of the Fe3+ ions in 1 were tested at room temperature, and the electrochemical behavior of 2 is also stated in this article

Redundant Reader Elimination in large-scale IoT City Networks

© 2019 IEEE. Radio Frequency Identification (RFID) is an important communication technology for the Internet of Things (IoT). With the development of IoT, RFID technology is widely deployed in large-scaled city networks. Under the circumstances, how to effectively optimize RFID network to decrease the operational cost of IoT is an ongoing research direction. In this area, one of the problems is the redundant reader issue, which means multiple RFID readers cover and interact with one RFID tag or many same tags, thereby resulting in massive energy cost. In order to solve this problem, quite a lot redundant reader elimination algorithms were presented to reduce unnecessary RFID readers. In this paper, the author proposes and compares three existing redundant reader elimination algorithms, including Redundant Reader Elimination Algorithm (RRE), Three-Count Based Algorithm (TCBA) and Threshold Selection Algorithm (TSA), to observe their performances. In the simulations, the author designs three experiments to test RFID reader\u27s detection radius, detection accuracy and algorithmic efficiency by observing the number of readers eliminated in different environmental sets. The simulation results show that TCBA can detect more redundant readers than RRE and TSA, but it costs more time. Compared with TCBA and RRE, the performance of TSA is more practical and efficient to satisfy real RFID environment and market\u27s needs

The Mechanism of Proinflammatory HDL Generation in Sickle Cell Disease Is Linked to Cell-Free Hemoglobin via Haptoglobin

<div><p>In sickle cell disease (SCD), the inflammatory properties of high-density lipoprotein (HDL) can be changed by cell-free hemoglobin (Hb), which is released into the blood during hemolysis. Hb in the plasma of SCD patients or mice can bind with HDL specifically inducing an inflammatory reaction. In our study, we found increased amounts of inflammatory factor proteins in the chronic oxidative state of SCD with higher levels of Hb, haptoglobin (Hp) and hemopexin (Hx) in the apolipoprotein A-I (ApoA-1) particles of HDL and the role of HDL is changed from being anti-inflammatory to proinflammatory. Our results also suggest Hp and Hx, the scavengers of Hb in HDL, are positively associated with inflammatory levels in SCD patients. HDL retained its inflammatory inhibition role in Hp−/− mice, with less Hb accumulation. Hx may further prevent inflammatory reaction because its level will be even higher when lack of Hx. We therefore demonstrated that Hp is indispensable during the process whereby Hb associates with HDL and plays a clear proinflammatory role. Therefore, it is essential to break the binding between Hb and Hp for treatment. The dissociation of Hb/Hp/Hx complexes may also play an important role in the study of other inflammatory angiogenesis-related diseases.</p></div

Levels of hemoglobin (Hb), haptoglobin (Hp) and hemopexin (Hx) associated with HDL in 32 sickle cell disease (SCD) patients and 28 healthy normal donors (Control).

<p>Levels of hemoglobin (Hb), haptoglobin (Hp) and hemopexin (Hx) associated with HDL in 32 sickle cell disease (SCD) patients and 28 healthy normal donors (Control).</p

Hemoglobin (Hb) concentrations associated with HDL were positively correlated with heme, reactive oxygen species (ROS) level and IL-6/IL-10.

<p>Relative Hb levels in the plasma (A1–A4 and C1–C4). Relative Hb [ApoA-1] = Hb associated with ApoA-1 particles from HDL (B1–B4 and D1–D4). Fig A1-A4 and B1-B4 present the data from the SCD group (n = 32) and Fig C1-C4 and D1-D4 are those from healthy donors (n = 28). Linear regression was performed individually and and p values and R² values are shown in the Figs. (NS = not significant).</p

Plasma hemoglobin (Hb), haptoglobin (Hp) and hemopexin (Hx) in HDL are linearly correlated with lipid hydroperoxide (LOOH) and HDL inflammatory index (HII). “[ApoA-1]” means “in ApoA-1 particles”.

<p>Results in SCD patients (n = 32): ApoA-1, Hb, Hp and Hx levels in plasma (A1–-A4, respectively) or ApoA-1 particles, Hb, Hp, and Hx associated with ApoA-1 (B1–B4, respectively) vs. LOOH content in ApoA-1 particles. ApoA-1, Hb, Hp and Hx levels in plasma (C1–C4) or those associated with ApoA-1 (D1–D4) vs. HII measured by monocyte chemotaxis activity (MCA). Linear regression was performed individually and p values and R² values are shown in the figures. (NS = not significant).</p

Hemopexin (Hp) is required to increase levels of p-HDL in SCD.

<p>The lipoprotein fractions were isolated by HPLC assay to detect p-HDL (accumulation of ROS) in wild-type (WT), Hp−/− and Hx−/− mice. A significantly lower level of p-HDL is seen in SCD mice with Hp knock-out, compared with other SCD groups, confirming that Hp is the protein necessary for the proinflammatory properties of HDL. (Other = other fractions of lipoprotein; RFU, relative fluorescence units).</p

Levels of inflammatory markers in plasma in 32 sickle cell disease (SCD) patients and 28 healthy normal donors.

<p>Levels of inflammatory markers in plasma in 32 sickle cell disease (SCD) patients and 28 healthy normal donors.</p