Boundedness of Parametrized Littlewood-Paley Operators with Nondoubling Measures

Let μ be a nonnegative Radon measure on â„Âd which only satisfies the following growth condition that there exists a positive constant C such that μ(B(x,r))≤Crn for all x∈â„Âd, r>0 and some fixed n∈(0,d]. In this paper, the authors prove that for suitable indexes àand λ, the parametrized gλ∗ function ℳλ∗,àis bounded on Lp(μ) for p∈[2,∞) with the assumption that the kernel of the operator ℳλ∗,àsatisfies some Hörmander-type condition, and is bounded from L1(μ) into weak L1(μ) with the assumption that the kernel satisfies certain slightly stronger Hörmander-type condition. As a corollary, ℳλ∗,àwith the kernel satisfying the above stronger Hörmander-type condition is bounded on Lp(μ) for p∈(1,2). Moreover, the authors prove that for suitable indexes àand λ,ℳλ∗,àis bounded from L∞(μ) into RBLO(μ) (the space of regular bounded lower oscillation functions) if the kernel satisfies the Hörmander-type condition, and from the Hardy space H1(μ) into L1(μ) if the kernel satisfies the above stronger Hörmander-type condition. The corresponding properties for the parametrized area integral ℳSàare also established in this paper

Transcatheter Treatment of Aortic Stenosis and Regurgitation

Since the successful application of transcatheter aortic valve implantation (TAVI) in 2002, the interventional treatment of valvular heart disease has developed rapidly. The interventional treatment of aortic valve stenosis or insufficiency has been more mature, and many new-generation TAVI valves have been developed. The recommended level of TAVI technology in the European and American heart valve disease guidelines has increased year by year. In 2019, the multi-center randomized controlled study on patients with low-risk aortic stenosis and conventional aortic valve replacement also showed the advantages of interventional treatment technology, such as small trauma, fast recovery and less complications, and better hemodynamics, which greatly promoted the development of TAVI technology

Using a Smart City IoT to Incentivise and Target Shifts in Mobility Behaviour-Is It a Piece of Pie?

The work presented in this paper is a central part of the research and development in the SUNSET project (contract No. 270228), supported by the 7th Framework Research Program funded by the European Commission. The authors also acknowledge the support of other SUNSET consortium members in helping to create and evaluate the SUNSET tripzoom system

Reservoir Characterization during Underbalanced Drilling of Horizontal Wells Based on Real-Time Data Monitoring

In this work, a methodology for characterizing reservoir pore pressure and permeability during underbalanced drilling of horizontal wells was presented. The methodology utilizes a transient multiphase wellbore flow model that is extended with a transient well influx analytical model during underbalanced drilling of horizontal wells. The effects of the density behavior of drilling fluid and wellbore heat transfer are considered in our wellbore flow model. Based on Kneissl’s methodology, an improved method with a different testing procedure was used to estimate the reservoir pore pressure by introducing fluctuations in the bottom hole pressure. To acquire timely basic data for reservoir characterization, a dedicated fully automated control real-time data monitoring system was established. The methodology is applied to a realistic case, and the results indicate that the estimated reservoir pore pressure and permeability fit well to the truth values from well test after drilling. The results also show that the real-time data monitoring system is operational and can provide accurate and complete data set in real time for reservoir characterization. The methodology can handle reservoir characterization during underbalanced drilling of horizontal wells

Compound Bieshe Kang’ai inhibits proliferation and induces apoptosis in HCT116 human colorectal cancer cells

Purpose: To study the effect of Compound Bieshe Kang’ai (CBK) on proliferation and apoptosis in colorectal cancer cells.Methods: HCT116 colorectal cancer cells and FHs 74 Int intestinal cells were treated with CBK, followed by determination of cell proliferation with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Caspase-9 and caspase-3 activities as well as protein expressions of Bcl-2 and BAX, and mRNA levels of caspase-9, caspase-3, Bcl-2 and BAX in HCT116 cells were evaluated, followed by examination of the morphological alterations of HCT116 cells with Hoechst 33342 staining.Results: CBK suppressed proliferation of HCT116 cells in a concentration- and time-dependent pattern, without cytotoxicity to FHs 74 Int cells. CBK also elevated caspase-9 and caspase-3 activities, mitigated protein translation of Bcl-2 and augmented that of BAX. It also enhanced mRNA transcriptions of caspase-9, caspase-3 and BAX, but decreased that of Bcl-2 in HCT116 cells in a  concentrationdependent manner, as well as induced cancer cell shrinkage, nuclear fragmentation and chromatin condensation.Conclusion: The findings highlight CBK as a promising therapeutic agent for colorectal cancers, by retarding proliferation and inducing apoptosis in cancer cells.Keywords: Apoptosis, BAX, Bcl-2, Cancer, Caspase, Compound Bieshe Kang’ai, Chromatin condensation, Nuclear fragmentatio

Numerical Simulation Study on Mechanical Characteristics of Submarine Cable During Laying Process

[Introduction] Based on an offshore wind farm construction project in Qidong, Jiangsu Province, the numerical simulation study on mechanical characteristics of submarine cable during laying process was carried out and the local stress distribution of the suspension span of submarine cables under different trenching depths was analyzed. [Method] A numerical model of submarine cable laying based on ABAQUS numerical simulation software was established. [Result] Results show that the stress of the lifting point at the trailing edge of the submarine cable increases significantly during the burial process compared with that before the burial operation. This is the most dangerous position as the cable at this position has the largest stress during the whole burial process. The trenching depth has a significant effect on the stress at the lifting point at the trailing edge of the cable. With the increase of the trenching depth, the stress at the lifting point at the trailing edge increases correspondingly. [Conclusion] The selection of cable material at the lifting point should be protected in the cable laying operation, and the yield stress parameters of the cable should be mainly based on the stress analysis results of the cable in the burial operation. The research results can provide a reference for submarine cable laying operation