The first 40 million years of circumstellar disk evolution: the signature of terrestrial planet formation

We characterize the first 40 Myr of evolution of circumstellar disks through a unified study of the infrared properties of members of young clusters and associations with ages from 2 Myr up to ~ 40 Myr: NGC 1333, NGC 1960, NGC 2232, NGC 2244, NGC 2362, NGC 2547, IC 348, IC 2395, IC 4665, Chamaeleon I, Orion OB1a and OB1b, Taurus, the \b{eta} Pictoris Moving Group, \r{ho} Ophiuchi, and the associations of Argus, Carina, Columba, Scorpius-Centaurus, and Tucana-Horologium. Our work features: 1.) a filtering technique to flag noisy backgrounds, 2.) a method based on the probability distribution of deflections, P(D), to obtain statistically valid photometry for faint sources, and 3.) use of the evolutionary trend of transitional disks to constrain the overall behavior of bright disks. We find that the fraction of disks three or more times brighter than the stellar photospheres at 24 {\mu}m decays relatively slowly initially and then much more rapidly by ~ 10 Myr. However, there is a continuing component until ~ 35 Myr, probably due primarily to massive clouds of debris generated in giant impacts during the oligarchic/chaotic growth phases of terrestrial planets. If the contribution from primordial disks is excluded, the evolution of the incidence of these oligarchic/chaotic debris disks can be described empirically by a log-normal function with the peak at 12 - 20 Myr, including ~ 13 % of the original population, and with a post-peak mean duration of 10 - 20 Myr.Comment: accepted for publication, the Astrophysical Journal (2017

Thin Solid Electrolyte Layers Enabled by Nanoscopic Polymer Binding

To achieve high-energy all-solid-state batteries (ASSBs), solid-state electrolytes (SE) must be thin, mechanically robust, and possess the ability to form low resistance interfaces with electrode materials. Embedding an inorganic SE into an organic polymer combines the merits of high conductivity and flexibility. However, the performance of such an SE-in-polymer matrix (SEPM) is highly dependent on the microstructure and interactions between the organic and inorganic components. We report on the synthesis of a free-standing, ultrathin (60 μm) SEPM from a solution of lithium polysulfide, phosphorus sulfide, and ethylene sulfide (ES), where the polysulfide triggers the in situ polymerization of ES and the formation of Li3PS4. Reactant ratios were optimized to achieve a room-temperature conductivity of 2 × 10-5 S cm-1. Cryogenic electron microscopy confirmed a uniform nanoscopic distribution of β-Li3PS4 and PES (polyethylene sulfide). This work presents a facile route to the scalable fabrication of ASSBs with promising cycling performance and low electrolyte loading

A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain

BACKGROUND: Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients. The purpose of this study is to identify genetic factors contributing to this type of pain in a general diabetic population. METHOD: We accessed the Genetics of Diabetes Audit and Research Tayside (GoDARTS) datasets that contain prescription information and monofilament test results for 9439 diabetic patients, among which 6927 diabetic individuals were genotyped by Affymetrix SNP6.0 or Illumina OmniExpress chips. Cases of neuropathic pain were defined as diabetic patients with a prescription history of at least one of five drugs specifically indicated for the treatment of neuropathic pain and in whom monofilament test result was positive for sensory neuropathy in at least one foot. Controls were individuals who did not have a record of receiving any opioid analgesics. Imputation of non‐genotyped SNPs was performed by IMPUTE2, with reference files from 1000 Genomes Phase I datasets. RESULTS: After data cleaning and relevant exclusions, imputed genotypes of 572 diabetic neuropathic pain cases and 2491 diabetic controls were used in the Fisher's exact test. We identified a cluster in the Chr8p21.3, next to GFRA2 with a lowest p‐value of 1.77 × 10(−7) at rs17428041. The narrow‐sense heritability of this phenotype was 11.00%. CONCLUSION: This genome‐wide association study on diabetic neuropathic pain suggests new evidence for the involvement of variants near GFRA2 with the disorder, which needs to be verified in an independent cohort and at the molecular level

Solving the Dirac equation with nonlocal potential by Imaginary Time Step method

The Imaginary Time Step (ITS) method is applied to solve the Dirac equation with the nonlocal potential in coordinate space by the ITS evolution for the corresponding Schr\"odinger-like equation for the upper component. It is demonstrated that the ITS evolution can be equivalently performed for the Schr\"odinger-like equation with or without localization. The latter algorithm is recommended in the application for the reason of simplicity and efficiency. The feasibility and reliability of this algorithm are also illustrated by taking the nucleus $^{16}$O as an example, where the same results as the shooting method for the Dirac equation with localized effective potentials are obtained

Matter loops corrected modified gravity in Palatini formulation

Recently, corrections to the standard Einstein-Hilbert action are proposed to explain the current cosmic acceleration in stead of introducing dark energy. In the Palatini formulation of those modified gravity models, there is an important observation due to Arkani-Hamed: matter loops will give rise to a correction to the modified gravity action proportional to the Ricci scalar of the metric. In the presence of such term, we show that the current forms of modified gravity models in Palatini formulation, specifically, the 1/R gravity and $\ln R$ gravity, will have phantoms. Then we study the possible instabilities due to the presence of phantom fields. We show that the strong instability in the metric formulation of 1/R gravity indicated by Dolgov and Kawasaki will not appear and the decay timescales for the phantom fields may be long enough for the theories to make sense as effective field theory . On the other hand, if we change the sign of the modification terms to eliminate the phantoms, some other inconsistencies will arise for the various versions of the modified gravity models. Finally, we comment on the universal property of the Palatini formulation of the matter loops corrected modified gravity models and its implications.Comment: 11 pages, 1 figures, References adde

ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma.

ZNF750 controls epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by its pathogenic mutations in esophageal squamous cell cancers (SCCs). However, the precise role of ZNF750 in SCC cell biology remains unclear. In this study, we report that ZNF750 is exclusively deleted, mutated and underexpressed in human SCCs, and low ZNF750 expression is associated with poor survival. Restoration of wildtype, but not mutant ZNF750 protein uniquely inhibited the malignant phenotypes of SCC cells both in vitro and in vivo. Notably, ZNF750 promoted the expression of a long non-coding RNA (TINCR), which mediated both cancer-inhibition and differentiation-induction effects of ZNF750. In addition, ZNF750 potently suppressed cell migration by directly inhibiting the transactivation of LAMC2. Together, our findings characterize ZNF750 as a crucial SCC-specific suppressor and uncover its novel anticancer-associated functions

A systematic study of Zr and Sn isotopes in the Relativistic Mean Field theory

The ground-state properties of Zr and Sn isotopes are studied within the relativistic mean field theory. Zr and Sn isotopes have received tremendous attention due to various reasons, including the predicted giant halos in the neutron-rich Zr isotopes, the unique feature of being robustly spherical in the region of $^{100}$Sn $\sim$ $^{132}$Sn and the particular interest of Sn isotopes to nuclear astrophysics. Furthermore, four (semi-) magic neutron numbers, 40, 50, 82 and 126, make these two isotopic chains particularly important to test the pairing correlations and the deformations in a microscopic model. In the present work, we carry out a systematic study of Zr and Sn isotopes from the proton drip line to the neutron drip line with deformation effects, pairing correlations and blocking effects for nuclei with odd number of neutrons properly treated. A constrained calculation with quadrupole deformations is performed to find the absolute minimum for each nucleus on the deformation surface. All ground-state properties, including the separation energies, the odd-even staggerings, the nuclear radii, the deformations and the single-particle spectra are analyzed and discussed in detail.Comment: the final version to appear in Modern Physics Letters A. more figures, discussions, and references added. the data remain unchange

Solid weak BCC-algebras

We characterize weak BCC-algebras in which the identity $(xy)z=(xz)y$ is satisfied only in the case when elements $x,y$ belong to the same branch

Adiabatic Gravitational Perturbation During Reheating

We study the possibilities of parametric amplification of the gravitational perturbation during reheating in single-field inflation models. Our result shows that there is no additional growth of the super-horizon modes beyond the usual predictions.Comment: Refs added; New version to appear in PR

Penetration Depth and Anisotropy in MgB2

The penetration depth lambda of MgB2 was deduced from both the ac susceptibility chi and the magnetization M(H) of sorted powders. The good agreement between the two sets of data without geometric correction for the grain orientation suggests that MgB2 is an isotropic superconductor.Comment: 9 pages, 5 figures; submitted to Physical Review B (February 28, 2001; revised June 28, 2001); reference list update