Age-independent increasing prevalence of Human Papillomavirus-driven oropharyngeal carcinomas in North-East Italy

HPV-driven oropharyngeal carcinomas (OPCs) show geographical variations with increasing temporal trends in several areas. We investigated their frequency and clinical outcomes within a prospective multicenter cohort study in North-East Italy. A tumor was defined as HPV-driven by using at least two different biomarkers, usually HPV-DNA positivity and p16INK4A overexpression. Different survival outcomes were compared among patients with HPV-driven and non-HPV-driven tumors. Overall, 42/130 (32.3%) patients with newly diagnosed OPC during the period 2000\u20132018 resulted HPV-driven; HPV16 was involved in 37 cases (88%), HPV33 in 3 cases (7%), HPV58 and HPV18 in 1 case each. Over time, HPV-driven cases raised from 16.7% (6/36) during 2000\u20132006 to 46.1% (24/52) during 2013\u20132018 (p < 0.001). The increase in HPV-driven OPCs was more marked in females than males (p = 0.010), and the frequency of HPV-driven cases was similar in the different age groups. In comparison to cases with non-HPV-driven tumors, a significantly (p < 0.001) better progression-free and overall survival were recorded among patients affected by HPV-driven OPC. The prevalence of HPV-driven OPC cases has been significantly increasing during the last two decades also in North-East Italy and was associated with favorable outcome. OPCs driven by non-HPV16 oncogenic types were restricted to patients older than 68-yrs

Age-independent increasing prevalence of Human Papillomavirus-driven oropharyngeal carcinomas in North-East Italy

HPV-driven oropharyngeal carcinomas (OPCs) show geographical variations with increasing temporal trends in several areas. We investigated their frequency and clinical outcomes within a prospective multicenter cohort study in North-East Italy. A tumor was defined as HPV-driven by using at least two different biomarkers, usually HPV-DNA positivity and p16INK4A overexpression. Different survival outcomes were compared among patients with HPV-driven and non-HPV-driven tumors. Overall, 42/130 (32.3%) patients with newly diagnosed OPC during the period 2000–2018 resulted HPV-driven; HPV16 was involved in 37 cases (88%), HPV33 in 3 cases (7%), HPV58 and HPV18 in 1 case each. Over time, HPV-driven cases raised from 16.7% (6/36) during 2000–2006 to 46.1% (24/52) during 2013–2018 (p < 0.001). The increase in HPV-driven OPCs was more marked in females than males (p = 0.010), and the frequency of HPV-driven cases was similar in the different age groups. In comparison to cases with non-HPV-driven tumors, a significantly (p < 0.001) better progression-free and overall survival were recorded among patients affected by HPV-driven OPC. The prevalence of HPV-driven OPC cases has been significantly increasing during the last two decades also in North-East Italy and was associated with favorable outcome. OPCs driven by non-HPV16 oncogenic types were restricted to patients older than 68-yrs

Serge Romoff - temoin inconnu

En mai 1921 et à Paris depuis une quinzaine d’années, Serge Romoff est appelé comme témoin au procès fictif de Maurice Barrès monté par les Dadaïstes et les Surréalistes. Bien qu’il soit presque certain qu’il connaissait plusieurs membres des deux groupes, il n’y a aucune trace de sa participation au cours des années précédentes ni à leurs activités ni à leurs publications. Qui donc était Serge Romoff?? La documentation manque, mais il semble qu’à partir de 1920 il joue un rôle de plus en plus important dans le monde culturel et surtout dans celui des artistes émigrés russes dans le quartier de Montparnasse. Il travaille dans l’imprimerie, fait quelques traductions, collabore à plusieurs revues culturelles, organise des expositions et écrit des articles de presse, notamment pour L’Humanité. En 1928 il retourne à Moscou où il continue à faire des conférences, probablement sur la littérature française et l’art. Il est mort en février 1939, une des victimes peut-être des purges staliniennes