47 research outputs found
Perancangan Media Komunikasi Visual Sebagai Promosi Susu Kambing Etawa Merek "Capra Latte" Di Surabaya
Full text linkSusu Kambing Etawa merek “Capra Latte” ini berdomisili di Surabaya bagian barat. Susu Kambing Etawa ini dikelolah dengan sangat bersih sehingga menjaga kemurnian dan kebersihannya. Produk yang dipasarkan adalah Susu Kambing Etawa rasa melon, stroberi dan original. Susu Kambing Etawa ini jauh lebih baik jika dibandingkan dengan susu sapi karena memiliki banyak manfaat, kandungan gizi dan tentunya tidak memiliki bau lebus khas kambing sehingga tidak menimbulkan rasa jijik disaat mengkonsumsinya. Namun seringkali terjadi salah presepsi terhadap masyarakat khususnya di Surabaya yang mengira bahwa susu kambing ini memiliki bau lebus khas kambing dan memiliki rasa tidak enak lagi pula sedikit masyarakat yang mengetahui tentang Susu Kambing Etawa merek “Capra Latte ini di Surabaya. Oleh karena itulah dibutuhkan media dan promosi yang dilakukan agar lebih memberikan edukasi dan minat terhadap para target audience dari Susu Kambing Etawa merek “Capra Latte” ini. Konsep promosi ini yaitu “Healthy Life, Healthy Drink”
An Assessment of the Impacts of Climate Variability and Change in KwaZulu-Natal Province, South Africa
Get PDFRainfall and air temperature variability pose the greatest risk to environmental change. Past trends in rainfall and air temperature facilitate projecting future climate changes for informed policy responses. We used a combination of the normalised difference vegetation index (NDVI) and observed data from 1968 to 2017 to assess changes in rainfall, moisture stress, and air temperature variability over time on bioclimatic regions of KwaZulu-Natal (KZN) Province, South Africa. Indicators used included consecutive dry days (CDDs), consecutive wet days (CWDs), very heavy rainfall days (R20), monthly maximum daily maximum air temperature (TXx), monthly minimum daily minimum air temperature (TNn), the total number of rainfall days, and monthly air temperature averages. Trends in rainfall and moisture stress are notable in different bioclimatic regions across the province. However, these trends are diverse, in general, and spatially different across and within the bioclimatic regions. Further, related rainfall indicators do not respond in the same way as would be expected. Air temperature trends were consistent with global trends and land–air temperature anomalies. Although daytime air temperatures showed a positive trend, extreme air temperature events and increases are predominant in inland regions. Night-time air temperatures showed an upward trend in most stations across KZN. Local weather-and-climate related characteristics are evolving due to climatic variability and change. The study shows that changes in climatic activities are detectable at a local level from existing historical weather data; therefore, adaptation strategies should be contextualised to respond to local and area-specific challenges
Study protocol for a phase 1/2, single-centre, double-blind, double-dummy, randomized, active-controlled, age de-escalation trial to assess the safety, tolerability and immunogenicity of a measles and rubella vaccine delivered by a microneedle patch in healthy adults (18 to 40 years), measles and rubella vaccine-primed toddlers (15 to 18 months) and measles and rubella vaccine-naïve infants (9 to 10 months) in The Gambia [Measles and Rubella Vaccine Microneedle Patch Phase 1/2 Age De-escalation Trial].
Get PDFBACKGROUND: New strategies to increase measles and rubella vaccine coverage, particularly in low- and middle-income countries, are needed if elimination goals are to be achieved. With this regard, measles and rubella vaccine microneedle patches (MRV-MNP), in which the vaccine is embedded in dissolving microneedles, offer several potential advantages over subcutaneous delivery. These include ease of administration, increased thermostability, an absence of sharps waste, reduced overall costs and pain-free administration. This trial will provide the first clinical trial data on MRV-MNP use and the first clinical vaccine trial of MNP technology in children and infants. METHODS: This is a phase 1/2, randomized, active-controlled, double-blind, double-dummy, age de-escalation trial. Based on the defined eligibility criteria for the trial, including screening laboratory investigations, 45 adults [18-40 years] followed by 120 toddlers [15-18 months] and 120 infants [9-10 months] will be enrolled in series. To allow double-blinding, participants will receive either the MRV-MNP and a placebo (0.9% sodium chloride) subcutaneous (SC) injection or a placebo MNP and the MRV by SC injection (MRV-SC). Local and systemic adverse event data will be collected for 14 days following study product administration. Safety laboratories will be repeated on day 7 and, in the adult cohort alone, on day 14. Unsolicited adverse events including serious adverse events will be collected until the final study visit for each participant on day 180. Measles and rubella serum neutralizing antibodies will be measured at baseline, on day 42 and on day 180. Cohort progression will be dependent on review of the unblinded safety data by an independent data monitoring committee. DISCUSSION: This trial will provide the first clinical data on the use of a MNP to deliver the MRV and the first data on the use of MNPs in a paediatric population. It will guide future product development decisions for what may be a key technology for future measles and rubella elimination. TRIAL REGISTRATION: Pan-African Clinical Trials Registry 202008836432905 . CLINICALTRIALS: gov NCT04394689
Maintaining Plasmodium falciparum gametocyte infectivity during blood collection and transport for mosquito feeding assays in the field.
Get PDFBACKGROUND: Mosquito feeding assays using venous blood are commonly used for evaluating the transmission potential of malaria infected individuals. To improve the accuracy of these assays, care must be taken to prevent premature activation or inactivation of gametocytes before they are fed to mosquitoes. This can be challenging in the field where infected individuals and insectary facilities are sometimes very far apart. In this study, a simple, reliable, field applicable method is presented for storage and transport of gametocyte infected blood using a thermos flask. METHODS: The optimal storage conditions for maintaining the transmissibility of gametocytes were determined initially using cultured Plasmodium falciparum gametocytes in standard membrane feeding assays (SMFAs). The impact of both the internal thermos water temperature (35.5 to 37.8 °C), and the external environmental temperature (room temperature to 42 °C) during long-term (4 h) storage, and the impact of short-term (15 min) temperature changes (room temp to 40 °C) during membrane feeding assays was assessed. The optimal conditions were then evaluated in direct membrane feeding assays (DMFAs) in Burkina Faso and The Gambia where blood from naturally-infected gametocyte carriers was offered to mosquitoes immediately and after storage in thermos flasks. RESULTS: Using cultured gametocytes in SMFAs it was determined that an internal thermos water temperature of 35.5 °C and storage of the thermos flask between RT (~ 21.3 °C) and 32 °C was optimal for maintaining transmissibility of gametocytes for 4 h. Short-term storage of the gametocyte infected blood for 15 min at temperatures up to 40 °C (range: RT, 30 °C, 38 °C and 40 °C) did not negatively affect gametocyte infectivity. Using samples from natural gametocyte carriers (47 from Burkina Faso and 16 from The Gambia), the prevalence of infected mosquitoes and the intensity of oocyst infection was maintained when gametocyte infected blood was stored in a thermos flask in water at 35.5 °C for up to 4 h. CONCLUSIONS: This study determines the optimal long-term (4 h) storage temperature for gametocyte infected blood and the external environment temperature range within which gametocyte infectivity is unaffected. This will improve the accuracy, reproducibility, and utility of DMFAs in the field, and permit reliable comparative assessments of malaria transmission epidemiology in different settings
