20 research outputs found
1-(4-Carboxybutan-2-ylidene)-4-phenylthiosemicarbazide
The molecule of the title compound, C12H15N3O2S, which belongs to the family of thiosemicarbazones, containing an acid group, adopts a semi-closed conformation with an intramolecular N—H⋯N hydrogen bond. In the crystal, molecules are linked by strong N—H⋯O and O—H⋯S hydrogen bonds between the acid group and thiosemicarbazone unit, with one additional intermolecular hydrogen C—H⋯O interaction. These three interactions form R
2
2(8) and a R
2
1(7) rings and the molecules related by the c-glide plane are linked into a zigzag chain along [001]
1-(Biphenyl-4-ylmethylidene)thiosemicarbazide monohydrate
In the title compound, C14H13N3S·H2O, the thiosemicarbazide group is nearly planar, with a maximum deviation of 0.072 (2) Å from the ideal least-squares plane, and shows an E conformation. In the crystal packing, the water molecules are involved in an extensive intermolecular N—H⋯O hydrogen-bond network, assisted by O—H⋯S interactions, which link the independent molecules into chains extended along b axis. An intramolecular hydrogen N—H⋯N bond helps to stabilize the molecular conformation
Structural study of diarylazoles related to Rimonabant
The structures of three diarylazoles (two pyrazoles and one 1,2,4-triazole) related to Rimonabant have
been determined by X-ray crystallography. The conformation of both aryl groups in the new structures
is discussed with regard to other related compounds reported in the Cambridge Structural Database.
The secondary structure of the three compounds is very different. Compound 2 forms a helix, compound
3 forms a structure with the hydrocarbon layers parallel and compound 4 crystallizes forming a double
chain. In the solid state, the conformation of both aryl groups, the N-aryl and the C-aryl, was compared
with similar compounds reported in the literature. GIAO calculations afford absolute shieldings that were
compared with experimental chemical shifts.This work was carried out with financial support from the Ministerio
de Educación y Ciencia (Project No. CTQ2007-61901/BQU)
and Comunidad Autónoma de Madrid (Project MADRISOLAR, ref.
S-0505/PPQ/0225). Mario Alvarado acknowledges a grant from
RETICS RD06/001/0014 (Instituto de Salud Carlos III). SG-G gratefully
acknowledges the financial support from MEC, projects
MAT2006-01997 and Consolider Ingenio-2010, ‘Factoría Española
de Cristalización’Peer reviewe
Structural study of diarylazoles related to Rimonabant
The structures of three diarylazoles (two pyrazoles and one 1,2,4-triazole) related to Rimonabant have
been determined by X-ray crystallography. The conformation of both aryl groups in the new structures
is discussed with regard to other related compounds reported in the Cambridge Structural Database.
The secondary structure of the three compounds is very different. Compound 2 forms a helix, compound
3 forms a structure with the hydrocarbon layers parallel and compound 4 crystallizes forming a double
chain. In the solid state, the conformation of both aryl groups, the N-aryl and the C-aryl, was compared
with similar compounds reported in the literature. GIAO calculations afford absolute shieldings that were
compared with experimental chemical shifts.This work was carried out with financial support from the Ministerio
de Educación y Ciencia (Project No. CTQ2007-61901/BQU)
and Comunidad Autónoma de Madrid (Project MADRISOLAR, ref.
S-0505/PPQ/0225). Mario Alvarado acknowledges a grant from
RETICS RD06/001/0014 (Instituto de Salud Carlos III). SG-G gratefully
acknowledges the financial support from MEC, projects
MAT2006-01997 and Consolider Ingenio-2010, ‘Factoría Española
de Cristalización’Peer reviewe
Synthesis, characterization and crystal structure of butyl N-(3-chloropropyl)-(2S)-alaninate hydrochloride
The synthesis of butyl N-(3-chloropropyl)-(2S)-alaninate hydrochloride is reported here. The compound was characterized by elemental analysis, infrared, and H-1- and C-13-NMR spectroscopy. The structure of butyl N-(3-chloropropyl)-(2S)-alaninate hydrochloride was continued by single-crystal X-ray analysis
The reaction of NH-indazoles with 1-fluoro-2,4-dinitrobenzene: the unusual formation of benzotriazole-N-oxides
15 páginas, 19 figuras, 7 tablas.When N-unsubstituted indazoles, like indazole itself, reacted with 1-fluoro-2,4-dinitrobenzene or 1-chloro-2,4,6-trinitrobenzene, three products were obtained whose structures were determined by X-ray diffraction. Besides the two N-substituted nitroaryl derivatives, a third compound was obtained with the same molecular formula (C13H8N4O4) to which was assigned the structure of a derivative of benzotriazole N-oxide. With the combined use of crystallography, NMR and DFT calculations this reaction was studied with special stress on the mechanism of formation of the benzotriazole-N-oxide.This work was supported by the Spanish Ministerio de Economía y Competitividad (MAT2010-15094, Factoría de Cristalización–Consolider Ingenio 2010) and FEDER funding. We also thank the Ministerio de Ciencia e Innovación (Project No. CTQ 2009-13129-C02-02) and the Comunidad Autónoma de Madrid (Project MADRISOLAR2, ref. S2009/PPQ-1533) for continuing support. F. P. C. thanks the Spanish MICINN (Grants CTQ2010-16959 and Ingenio-Consolider CSD2007-00006) and the Basque Government (GV-EJ, Grant IT-324-07) for financial support.Peer reviewe