Can corruption erode confidence in political institutions smong European countries? comparing the effects of different measures of perceived corruption

The purpose of this study is to analyze the effects of corruption on institutional confidence through testing alternative perceptions-based indexes of corruption. Scholars who have investigated this topic have often employed only indicators of corruption based on experts\u2019 surveys. In this article we also consider a new index of corruption developed aggregating citizens\u2019 perceptions. The first part of the paper explores the levels of corruption perceived by the citizens of EU member states, stressing the differences with the experts\u2019 opinions. The second part tests, through a multivariate analysis, the impact of citizens\u2019 and experts\u2019 perceptions-based indexes of corruption on institutional confidence. The main results show that experts and citizens tend to express similar opinions on the extent of corruption in EU member states though, especially in some countries, these actors present some noticeable differences. Nevertheless, irrespective of the indexes used, more corrupt countries are characterized by lower levels of confidence in parliament and government. This relationship holds even controlling for the presence of reverse causality between corruption and confidence

Recent results in animal models of pancreatic carcinoma: histogenesis of tumors.

Animal models of carcinoma of the pancreas provide new information regarding the pathways for histogenesis of the tumors. Four models, induced by chemical carcinogens or transgenic methods, are reviewed briefly from this perspective. Recent reports indicate that carcinomas with a ductal phenotype can arise from transformed acinar cells in rodents. A transgenic mouse model provides evidence that anaplastic carcinomas and islet cell tumors may arise from primitive cells that express the elastase gene, yet retain the potential to differentiate as islet cells. In a nitrosamine-induced hamster model, ductal carcinomas appear to arise directly from ductal cells. Carcinomas in this model contained mutations in the c-K-ras oncogene that are similar to those reported in about 75 percent of human pancreatic carcinomas, whereas acinar cell carcinomas of rats lacked this mutation. The histologic type of a carcinoma may reflect the cell of origin, but this statement is not always true. Therefore, classification of tumors on the basis of phenotype rather than on the presumed cell of origin is recommended. Among the animal models, the carcinomas in hamster pancreas rank as most similar to human pancreatic ductal adenocarcinomas in regard to the phenotype of the tumors and the prevalence of the c-K-ras mutation

HEMODIALYSIS-RELATED LYMPHOMONONUCLEAR RELEASE OF INTERLEUKIN 12 IN PATIENTS WITH END-STAGE RENAL DISEASE.

Abstract: Interleukin-12 (IL-12) is a cytokine produced by peripheral blood mononuclear cells (PBMC) that causes interferon-gamma (IFN-gamma) production and enhancement of cell-mediated cytotoxicity. To clarify the role of hemodialysis biocompatibility on IL-12 production and uremic immunodeficiency, we have studied the IL-12 and IFN-gamma release by PBMC harvested from 12 patients dialyzed with cuprophan membrane (CU), eight patients dialyzed with polymethylmethacrylate membrane (PMMA), and eight nondialyzed uremic patients (UR). Ten healthy subjects constituted the control group (CON). PBMC were cultured for 48 h with and without nonspecific mitogen stimulation. In unstimulated conditions, CU showed an IL-12 PBMC production higher than CON, UR, and PMMA (46.67 +/- 30.13 versus 2.56 +/- 1.38, 6.16 +/- 7.09, and 4.62 +/- 4.76 pg/ml, respectively; P < 0.01). IL-12 production was correlated with C3a concentration measured at the outlet of hemodialyzer after 15 min of dialysis (r = 0.69, P < 0.01). IL-12 release in CU remained unchanged under mitogen stimulation (44.34 +/- 23.86 pg/ml) and was lower than in CON, UR, and PMMA (66.0 +/- 12.41, 68.37 +/- 25.78, and 67.75 +/- 22.61 pg/ml, respectively; P < 0.05). IFN-gamma production was similar, in unstimulated conditions, in all groups. Under stimulation, IFN-gamma release was lower in CU (13.42 +/- 12.04 IU/ml) than in CON, UR, and PMMA (51.84 +/- 30.74, 32.16 +/- 13.86, and 32.16 +/- 13.86 IU/ml, respectively; P < 0.01). These results demonstrate that hemodialysis with CU induces monocyte activation with an enhanced release of IL-12. On the contrary, stimulated PBMC production of both IL-12 and IFN-gamma is lower in these patients than in CON, UR, and PMMA. The altered release of these cytokines could play a role in cell-mediated immunodeficiency of the uremic patients dialyzed with CU

Plant cover and management practices as drivers of soil quality

Human activities intensively modify soil properties and quality according to land-use and management practices. In Mediterranean areas, pollution and fires may directly alter some soil abiotic properties as well as the steady-state condition of soil microbiota. The aim of this study was to evaluate if the chemical and biological characteristics of two kinds of soil, Arenosols and Andosols, of a natural reserve and an urban park respectively, were affected by the same or different plant covers (trees and grasses). At each site, five sub-samples of surface soils (0–10 cm) were collected under maquis (trees) and gap of grasses. The soils were analyzed for physico-chemical parameters (organic matter and water contents, pH, C, N, Cr, Cu, Ni and Pb concentrations) and biological parameters (microbial and fungal biomass, respiration, metabolic quotient and coefficient of endogenous mineralization). The soil quality was evaluated through an integrated index, calculated taken into account all the investigated parameters. The results highlighted that soils under trees inside the urban park, with the highest amount of organic matter, showed higher microbial biomass and activity as compared to soils under grasses. The high concentration of Cu and Pb in these latter soils inhibited the microbial biomass and activity that were not exclusively affected by litter quality. Soil quality would seem to be strongly affected by the pedogenetic derivation and the management practices more than plant covers

Un-biodegradable and biodegradable plastic sheets modify the soil properties after six months since their applications

Nowadays, microplastics represent emergent pollutants in terrestrial ecosystems that exert impacts on soil properties, affecting key soil ecological functions. In agroecosystems, plastic mulching is one of the main sources of plastic residues in soils. The present research aimed to evaluate the effects of two types of plastic sheets (un-biodegradable and biodegradable) on soil abiotic (pH, water content, concentrations of organic and total carbon, and total nitrogen) and biotic (respiration, and activities of hydrolase, dehydrogenase, β-glucosidase and urease) properties, and on phytotoxicity (germination index of Sorghum saccharatum L. and Lepidium sativum L.). Results revealed that soil properties were mostly affected by exposure time to plastics rather than the kind (un-biodegradable and biodegradable) of plastics. After six months since mesocosm setting up, the presence of un-biodegradable plastic sheets significantly decreased soil pH, respiration and dehydrogenase activity and increased total and organic carbon concentrations, and toxicity highlighted by S. saccharatum L. Instead, the presence of biodegradable plastic sheets significantly decreased dehydrogenase activity and increased organic carbon concentrations. An overall temporal improvement of the investigated properties in soils covered by biodegradable plastic sheets occurred

Preliminary Feasibility Study of a Water Space Reactor with an Innovative Reactivity Control System

Power limitation represents a major issue within space applications aimed to human settlements on solar system planets. Among these planets, Mars is considered the most attractive because of its nearness to the Earth and the probable presence of minerals which can be used by the settlers to live off the land. In this frame, small size nuclear power plants can be an interesting solution to overcome the energy supply problem. This paper presents a preliminary feasibility study of a 100 kWe self-pressurized water space reactor, with the aim to design a system characterized by compactness, intrinsic safety and simplicity of the main reactor control components. To this end an innovative reactivity control system, based on the control of the primary coolant mass flow rate, was adopted. The introduction of this system in the reactor design required a comprehensive core neutronics analysis in order to properly quantify the effect of the coolant on the reactor behaviour also as a function of the fuel burn-up. Here only the main results of this analysis, concerning neutron flux profiles and multiplication factors, are discussed. Moreover preliminary results on long term reactivity control are presented, showing the possibility to operate the reactor for as long as 7 years with no need of human intervention

Variation of the chemical and biological properties of a Technosol during seven years after a single application of compost

Technosols are composed of natural soils mixed with artificial materials and can be an inhospitable environment for the soil microbial community. The main goal of the current research was to evaluate temporal variations of Technosol quality through an integrated approach, considering all of the evaluated chemical, physical and biological characteristics for a period of seven years after a single application of compost. The soil samples were evaluated using the following parameters: pH; water content; water holding capacity; bulk density; porosity; organic matter and N contents; C/N ratio; fungal biomass; microbial biomass; respiration; metabolic quotient (qCO 2 ); and endogenous mineralisation coefficient (CEM). The overall evaluation showed that a single application of compost improved the soil quality in the short term. A decrease in Technosol quality over the long term appears to be due to deterioration of the physical and chemical properties, rather than a change in biological properties

Acoustic force measurements on polymer-coated microbubbles in a microfluidic device

This work presents an acoustofluidic device for manipulating coated microbubbles, designed for the simultaneous use of optical and acoustical tweezers. A comprehensive characterization of the acoustic pressure in the device is presented, obtained by the synergic use of different techniques in the range of acoustic frequencies where visual observations showed aggregation of polymer-coated microbubbles. In absence of bubbles, the combined use of laser vibrometry and finite element modelling supported a non-invasive measurement of the acoustic pressure and an enhanced understanding of the system resonances. Calibrated holographic optical tweezers were used for direct measurements of the acoustic forces acting on an isolated microbubble, at low driving pressures, and to confirm the spatial distribution of the acoustic field. This allowed quantitative acoustic pressure measurements by particle tracking, using polystyrene beads, and an evaluation of the related uncertainties. This process facilitated the extension of tracking to microbubbles, which have a negative acoustophoretic contrast factor, allowing acoustic force measurements on bubbles at higher pressures than optical tweezers, highlighting four peaks in the acoustic response of the device. Results and methodologies are relevant to acoustofluidic applications requiring a precise characterization of the acoustic field and, in general, to biomedical applications with microbubbles or deformable particles

Impact of anthropic activities on soil quality under different land uses

Anthropization often leads to land use transformation, causing deep changes to soil properties and its quality. Land use change could be an environmental and socioeconomic problem, as it impacts soil quality and ecosystem services. There is an urgent need to understand the pressures affecting soil quality. The aim of the work is to quantify the impact of different land uses on soil abiotic and biotic properties and on its quality. To achieve the aims, soils from different land uses (forest, urban and agricultural) were collected in the surroundings of Naples and analyzed for pH, water content, contents of C and N, C/N ratio and total and available concentrations of Cu, Ni and Pb, microbial and fungal biomasses, basal respiration and metabolic quotient. Then, a soil quality index (SQI) was calculated for each land use. The results showed that soil abiotic and biotic properties of the agricultural sites differed from those of forest and urban sites. At agricultural sites, microbial abundances decreased due to low amount of C and N and to high amount of Cu and Pb. This caused low use efficiency of energetic substrates and a reduced soil quality of agricultural sites as compared to forest and urban sites