Intercalation of Ciprofloxacin in Naturally Occurring Smectite from Bana: Potentiality as Drug Delivery System and Antimicrobial Effects on Escherichia coli and Staphylococcus aureus

International audienceCiprofloxacin (CFX) was loaded on Bana clay (Cameroon) and CFX loadedclayshave been evaluated as drug delivery system. Raw clays and CFX loadedcompounds have been characterized by some physico-chemicals methods. Invitro release studies have been done in gastric and phosphate buffer experimentalmediums; bacteriological studies have been made up on Escherichia coliand Staphylococcus aureus. X-ray diffractometry patterns of loaded compoundsshow a basal spacing increasing due to CFX intercalation. On Fourier-TransformedInfrared spectrometry spectra, appearance of CFX characteristic bandsand shifting of certain bands already presents on clay confirmed CFX intercalation.After 96 h of CFX released from release mediums, prolonged and continueprofiles have been observed. Diffusion tests displayed an inhibition radiusof ~2 cm on gelose seeded with Escherichia coli and Staphylococcus aureusdue to CFX. The overall results show a modified release of ciprofloxacinwith an effective antibacterial activity, giving the way for a new ciprofloxacindrug delivery system using Bana clay as carrier