Statistical Tests.

<p>Factors: N, Neuroticism; E, Extraversion; O, Openness; A, Agreeableness; C, Conscientiousness</p><p>Correlations and p-values are shown in each box with corrections for age, BMI and antipsychotic dose shown in the parentheses. Significant correlations are bolded with those remaining significant after correction marked with an asterisk.</p

Scatter plot of openness factor score and (a) serum ALA:DHA ratio or (b) FADS2 activity.

<p>Graphs show a significant negative correlation between openness factor score and serum ALA:DHA ratio (p = 0.008, r = −0.498) and a significant positive correlation between openness factor score and FADS2 activity (p = 0.036, r = −0.406).</p

Schematic of biosynthetic pathway for common n-3 and n-6 fatty acids.

<p>Major dietary inputs are shown with arrows and enzymes catalyzing each conversion are given.</p

Scatter plots of ALA:EPA ratio, EPA:DHA ratio and both agreeableness and extraversion factor scores.

<p>Graphs show significant correlations between ALA:EPA and agreeableness (p = 0.023, r = −0.436) and extraversion (p = 0.045, r = −0.389) and significant positive correlations between EPA:DHA and agreeableness (p = 0.024, r = 0.433) and extraversion (p = 0.048, r = 0.384).</p

Subject Data.

<p>Atypical antipsychotic (AAP) medications are given with actual dose and chlorpromazine equivalents (CPZ eqs.). Body mass index (BMI) and history of suicide attempt (Suicidal Hx), either Yes or No are also reported.</p

Significant VS PE-related activity was observed at time 1 (A) but not time 2 (B).

<p>Significant VS RE-related activation was observed at time 2 (C) but not time 1 (D). Figures thresholded at p<0.025 uncorrected, and masked with the ROI, for display purposes. Bar charts of extracted parameter estimates, displaying the mean PE-related (E) and RE-related (F) findings within the entire VS regions of interest. Error bars reflect standard errors of the mean (SEM). (G). Whole brain PE activations at time 1, thresholded at p<0.001, k>200.</p

Figure shows the structure of the guessing task, including phases for response, anticipation and outcome (only reward-related feedback shown).

<p>Figure shows the structure of the guessing task, including phases for response, anticipation and outcome (only reward-related feedback shown).</p

Left: Change in right VS RE activation from time 1 to time 2 is negatively correlated with the change in right VS PE activation from time 1 to time 2.

<p>Right: Right VS RE activation at time 1 is negatively correlated with right VS PE activation at time 1.</p

Table describing model fit and associated statistics of two regression models applied to key variables of interest (RE/PE) in the present study.

<p>Parametric ordinary or weighted least squares regression were used throughout, aside from the association of loading score with the squared residuals generated by the basic model, in which we used Spearman’s Rho.</p><p>Table describing model fit and associated statistics of two regression models applied to key variables of interest (RE/PE) in the present study.</p