3 research outputs found
LSST Project Data Products
<p>Presentation slides for the following conference.</p>
<p>Supernovae: The LSST Revolution<br>
May 31 - June 2, 2017<br>
Northwestern University, Evanston IL<br>
Website: https://sites.northwestern.edu/lsstcsupernovae17ciera/<br>
Ā </p
Additional file 1: Table S1. of The relationship between working conditions and self-rated health among medical doctors: evidence from seven waves of the Medicine In Australia Balancing Employment and Life (Mabel) survey
Psychosocial job stressors and self-rated health, female doctors, random and fixed effect regression models using a continuous outcome measure, adjusted for all variables, MABEL, 2001 to 2008. Table S2. Psychosocial job stressors and self-rated health, male doctors, random and fixed effect regression models using a continuous outcome measure, adjusted for all variables, MABEL, 2001 to 2008. Fixed-effect regression model. (DOCX 108 kb
Piperazine Oxadiazole Inhibitors of Acetyl-CoA Carboxylase
Acetyl-CoA
carboxylase (ACC) is a target of interest for the treatment
of metabolic syndrome. Starting from a biphenyloxadiazole screening
hit, a series of piperazine oxadiazole ACC inhibitors was developed.
Initial pharmacokinetic liabilities of the piperazine oxadiazoles
were overcome by blocking predicted sites of metabolism, resulting
in compounds with suitable properties for further in vivo studies.
Compound <b>26</b> was shown to inhibit malonyl-CoA production
in an in vivo pharmacodynamic assay and was advanced to a long-term
efficacy study. Prolonged dosing with compound <b>26</b> resulted
in impaired glucose tolerance in diet-induced obese (DIO) C57BL6 mice,
an unexpected finding