3 research outputs found

    LSST Project Data Products

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    <p>Presentation slides for the following conference.</p> <p>Supernovae: The LSST Revolution<br> May 31 - June 2, 2017<br> Northwestern University, Evanston IL<br> Website: https://sites.northwestern.edu/lsstcsupernovae17ciera/<br> Ā </p

    Additional file 1: Table S1. of The relationship between working conditions and self-rated health among medical doctors: evidence from seven waves of the Medicine In Australia Balancing Employment and Life (Mabel) survey

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    Psychosocial job stressors and self-rated health, female doctors, random and fixed effect regression models using a continuous outcome measure, adjusted for all variables, MABEL, 2001 to 2008. Table S2. Psychosocial job stressors and self-rated health, male doctors, random and fixed effect regression models using a continuous outcome measure, adjusted for all variables, MABEL, 2001 to 2008. Fixed-effect regression model. (DOCX 108 kb

    Piperazine Oxadiazole Inhibitors of Acetyl-CoA Carboxylase

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    Acetyl-CoA carboxylase (ACC) is a target of interest for the treatment of metabolic syndrome. Starting from a biphenyloxadiazole screening hit, a series of piperazine oxadiazole ACC inhibitors was developed. Initial pharmacokinetic liabilities of the piperazine oxadiazoles were overcome by blocking predicted sites of metabolism, resulting in compounds with suitable properties for further in vivo studies. Compound <b>26</b> was shown to inhibit malonyl-CoA production in an in vivo pharmacodynamic assay and was advanced to a long-term efficacy study. Prolonged dosing with compound <b>26</b> resulted in impaired glucose tolerance in diet-induced obese (DIO) C57BL6 mice, an unexpected finding
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