Kaplan-Meier curves for overall survival based on receptor group.

<p>Kaplan-Meier curves for overall survival based on receptor group.</p

Kaplan-Meier curves for time to relapse based on receptor group.

<p>Kaplan-Meier curves for time to relapse based on receptor group.</p

Treatment with ATB-346 reduced intestinal β-catenin and cMyc levels in APC^Min/+ mice.

<p>Expression of both β-catenin (panel A) and cMyc (panel B) were significantly elevated in colonic tissue from APC^Min/+ mice as compared to wild-type mice. Treatment of APC^Min/+ mice with ATB-346 (14.5 mg/kg) significantly reduced β-catenin and cMyc expression to levels comparable to those in wild-type mice, while naproxen treatment (10 mg/kg) reduced cMyc but not β-catenin. Tissue samples were collected from the mice at 14 weeks of age, while drug treatment occurred in the 6^th and 7^th weeks of age. Each bar represents the mean ± SEM for at least 4 mice (p<0.05 vs. wild-type mice; ^ψp<0.05 vs. wild type. *p<0.05 vs. naproxen-treated).</p

Summary of transcriptomics analysis.

<p>Genes altered by >1.5-fold in the colon of APC^Min/+ mice as compared to wild-type mice, and the effects of daily treatment for one week with naproxen or ATB-346. Fold-change values represent direction of change from the first listed condition to the second. During the 6^th week of age, mice were treated with vehicle, naproxen at a dose of 10 mg/kg, or ATB-346 at an equimolar dose. Tissue samples were harvested at the start of the 7^th week of age. *p<0.05 by one-way ANOVA with Student-Neuman-Keuls post-hoc test and Storey’s bootstrapping multiple comparison correction. n = 6-8/group.</p

Hazard density plot depicting timing of relapse based on receptor status.

<p>Hazard density plot depicting timing of relapse based on receptor status.</p

Demographics and Internet usage pattern of youths who do and do not express distress online.

<p>Demographics and Internet usage pattern of youths who do and do not express distress online.</p

Univariable and multivariable analyses for time to relapse in sensitivity analysis excluding patients with HER2-positive disease.

<p>Univariable and multivariable analyses for time to relapse in sensitivity analysis excluding patients with HER2-positive disease.</p

Polyp formation in the small intestine and colon of APC^Min+ mice at 12 weeks of age.

<p>Panel A shows ileum from a wild-type (C57Bl/6) mouse, while panel B shows ileum from an APC^Min+ mouse (with numerous polyps visible in the latter). Panel C shows the Polyp Score for 12 APC^Min+ mice, illustrating the regional variation through the small intestine and colon. Each line represents the results from one mouse. The ileum exhibited the greatest polyp score, while the colon exhibited the lowest.</p

Demographics and usage of Internet platforms of all youths surveyed.

<p>Demographics and usage of Internet platforms of all youths surveyed.</p

Colon-specific reduction/reversal of polyps.

<p>Initiation of treatment with ATB-346 (14.5 mg/kg once daily for 14 days) at week 12 had no effect on the small intestinal polyp score (assessed at week 14), but markedly reduced polyp formation in the colon (**p<0.01).</p