Development of DFSI using Fuzzy Logic to Analyze Risk Levels of Driving Activity

The objective of this study is to develop a Driving Fatigue Strain Index using fuzzy logic to analyze the risk levels of driving activity among road users. Driving fatigue is always related to the driving activity and has been identified as one of the vital contributors to the road accidents and fatalities in Malaysia. Therefore, the present paper introduces the use of fuzzy logic for the development of strain index to provide the systematic analysis and propose an appropriate solution in minimizing the number of road accidents and fatalities. The development of strain index is based on the six risk factors associated with driving fatigue; muscle activity, heart rate, hand grip pressure force, seat pressure distribution, whole-body vibration, and driving duration. The data is collected for all the risk factors and consequently, the three conditions or risk levels are defined as “safe”, “slightly unsafe”, and “unsafe”. A membership function is defined for each fuzzy conditions. IF-THEN rules were used to define the input and output variables which correspond to physical measures. This index is a reliable advisory tool for providing analysis and solutions to driving fatigue problem, which constitutes the first effort toward the minimization of road accidents and fatalities

p73: A Multifunctional Protein in Neurobiology

p73, a transcription factor of the p53 family, plays a key role in many biological processes including neuronal development. Indeed, mice deficient for both TAp73 and ΔNp73 isoforms display neuronal pathologies, including hydrocephalus and hippocampal dysgenesis, with defects in the CA1-CA3 pyramidal cell layers and the dentate gyrus. TAp73 expression increases in parallel with neuronal differentiation and its ectopic expression induces neurite outgrowth and expression of neuronal markers in neuroblastoma cell lines and neural stem cells, suggesting that it has a pro-differentiation role. In contrast, ΔNp73 shows a survival function in mature cortical neurons as selective ΔNp73 null mice have reduced cortical thickness. Recent evidence has also suggested that p73 isoforms are deregulated in neurodegenerative pathologies such as Alzheimer’s disease, with abnormal tau phosphorylation. Thus, in addition to its increasingly accepted contribution to tumorigenesis, the p73 subfamily also plays a role in neuronal development and neurodegeneration

Development of driving fatigue strain index using fuzzy logic to analyze risk levels of driving activity

The objective of this study is to develop a driving fatigue strain index using fuzzy logic to analyze the risk levels of driving activity among road users. Driving fatigue is always related to the driving activity and has been identified as one of the vital contributors to the road accidents and fatalities in Malaysia. Therefore, the present article introduces the use of fuzzy logic for the development of strain index to provide the systematic analysis and propose an appropriate solution in minimizing the number of road accidents and fatalities. The development of strain index is based on the six risk factors associated with driving fatigue; muscle activity, heart rate, hand grip pressure force, seat pressure distribution, whole-body vibration, and driving duration. The data are collected for all the risk factors, and consequently the three conditions or risk levels are defined as ‘safe’, ‘slightly unsafe’, and ‘unsafe’. A membership function is defined for each fuzzy condition. IF-THEN rules were used to define the input and output variables, which correspond to physical measures. This index is a reliable advisory tool for providing analysis and solutions to driving fatigue problem, which constitutes the first effort toward the minimization of road accidents and fatalities

Effect of Dietary Garcinia cambogia Extract on Serum Essential Minerals (Calcium, Phosphorus, Magnesium) and Trace Elements (Iron, Copper, Zinc) in Rats Fed with High-Lipid Diet

The aim of the study was to investigate the effect of Garcinia cambogia extract on serum calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe), zinc (Zn) and copper (Cu) concentrations in rats fed with the normal or the high-lipid and -cholesterol diet. Thirty 1-year-old female Sprague-Dawley rats (pathogen-free), weighing an average of 229 g, were randomly assigned to three experimental groups of ten animals each. Diets and tap water were given ad libitum for 75 days. Group 1 (control group) was fed with basal diet (2 % liquid vegetable oil, 0 % cholesterol), while the diets of groups 2 and 3 contained vegetable oil (2 % liquid vegetable oil and 5 % hydrogenated vegetable oil) and cholesterol (3 %) in high levels. 4,5 % G. cambogia extract containing 65 % HCA was added to the diet of group 3 as from day 45. Blood samples were withdrawn on days 0, 45 and 75. Serum mineral levels were analyzed using standard enzymatic colorimetric methods with a spectrophotometer. All significant differences were p < 0.05. Serum Ca levels were not significantly different between all groups on days 45 and 75. Serum P level was significantly higher in the group fed with high-lipid diet and G. cambogia extract than in the control group on day 45. Serum Mg level was significantly higher in group 2 than in the control group on day 45. Serum Fe levels were significantly lower in the control group than in the other groups on days 45 and 75. Serum Zn level of the group fed with high-lipid diet and G. cambogia extract was significantly higher than in the control group on day 75. Serum Cu levels were significantly higher in group 2 than in the control group, and in group 3 than in group 2 on day 75. In conclusion, a diet containing the high fat amounts may lead to the increase in circular levels of some minerals due to the short-chain fatty acid production lowering the luminal pH which increases mineral solubility, or serving as a fuel for mucosal cells and stimulating cell proliferation in the large intestine. G. cambogia extract may be used in the P and Cu deficiencies due to increases resulting in the present P and Cu amounts in G. cambogia extract, or the use of phytate P in diet. It was hoped that with further evidence-based study this product will enter to mainstream medicines