Electrical power aspects of distributed propulsion systems in turbo-electric powered aircraft

The aerospace industry is currently looking at options for fulfilling the technological development targets set for the next aircraft generations. Conventional engines and aircraft architectures are now at a maturity level which makes the realisation of these targets extremely problematic. Radical solutions seem to be necessary and Electric Distributed Propulsion is the most promising concept for future aviation. Several studies showed that the viability of this novel concept depends on the implementation of a superconducting power network. The particularities of a superconducting power network are described in this study where novel components and new design conditions of these networks are highlighted. Simulink models to estimate the weight of fully superconducting machines have been developed in this research work producing a relatively conservative prediction model compared to the NASA figures which are the only reference available in the literature. A conceptual aircraft design architecture implementing a superconducting secondary electrical power system is also proposed. Depending on the size of the aircraft, and hence the electric load demand, the proposed superconducting architecture proved to be up to three times lighter than the current more electric configurations. The selection of such a configuration will also align with the general tendency towards a superconducting network for the proposed electric distributed propulsion concept. In addition, the hybrid nature of these configurations has also been explored and the potential enhanced role of energy storage mechanisms has been further investigated leading to almost weight neutral but far more flexible aircraft solutions. For the forecast timeframe battery technology seems the only viable choice in terms of energy storage options. The anticipated weight of the Lithium sulphur technology is the most promising for the proposed architectures and for the timeframe under investigation. The whole study is based on products and technologies which are expected to be available on the 2035 timeframe. However, future radical changes in energy storage technologies may be possible but the approach used in this study can be readily adapted to meet such changes

Excision Repair Cross-Complementation Group 1 Enzyme as a Molecular Determinant of Responsiveness to Platinum-Based Chemotherapy for non Small-Cell Lung Cancer

Although platinum-based chemotherapy remains the “standard” in advanced non small-cell lung cancer, not all patients derive clinical benefit from such a treatment. Hence, the development of predictive biomarkers able to identify lung cancer patients who are most likely to benefit from cisplatin-based chemotherapy has become a scientific priority. Among the molecular pathways involved in DNA damage control after chemotherapy, the nucleotide excision repair (NER) is a critical process for the repair of DNA damage caused by cisplatin-induced DNA adducts. Many reports have explored the role of the excision repair cross-complementation group 1 enzyme (ERCC1) expression in the repair mechanism of cisplatin-induced DNA adducts in cancer cells

High quality factor nitride-based optical cavities: microdisks with embedded GaN/Al(Ga)N quantum dots

We compare the quality factor values of the whispery gallery modes of microdisks incorporating GaN quantum dots (QDs) grown on AlN and AlGaN barriers by performing room temperature photoluminescence (PL) spectroscopy. The PL measurements show a large number of high Q factor (Q) resonant modes on the whole spectrum which allows us to identify the different radial mode families and to compare them with simulations. We report a considerable improvement of the Q factor which reflect the etching quality and the relatively low cavity loss by inserting QDs into the cavity. GaN/AlN QDs based microdisks show very high Q values (Q > 7000) whereas the Q factor is only up to 2000 in microdisks embedding QDs grown on AlGaN barrier layer. We attribute this difference to the lower absorption below bandgap for AlN barrier layers at the energies of our experimental investigation

Optoelectronic properties of InAs GaAs columnar quantum dot laser diodes

In this thesis results are described with the aim of examining the optoelectronic properties of InAs/GaAs columnar quantum-dots and comparing them with those of more conventional self-assembled quantum-dots. The polarisation properties of a set of columnar quantum-dot samples — of varied aspect ratio and In compositional contrast between the rod-shaped dot and the surrounding 2-D layer — are studied. For this investigation a new method to obtain the ratio of the fundamental TE/TM optical response using edge photo-absorption spectroscopy is proposed, which corrects for the polarisation-dependent features of the experimental set-up. The method is verified by application to compressive and tensile strained InGaP quantum well structures, where the results are in agreement with known ratios of the band-edge matrix elements. When applied to columnar quantum-dot samples it is shown that the TE/TM optical response depends on the dot aspect ratio and the In compositional contrast. A polarisation-independent photo-absorption is illustrated for a columnar quantum-dot of an aspect ratio (dot's height over diameter) 3.51:1, which is desired for use in semiconductor optical amplifiers. For the columnar dot of an extremely high aspect ratio, 7.5:1, a room temperature TM-dominant polarisation lasing emission is observed. By studying the Quantum-Confined Stark Effect, a dramatic enhancement of the Stark shift amplitude is shown for columnar quantum-dot samples of an increased dot aspect ratio from 0.63:1 up to 1.12:1, which may have application in optical modulation/switching. For a higher aspect ratio columnar quantum-dot the shift of the band edge of the photo-absorption spectra is reduced dramatically and this has been attributed to an overall effect where the observable shift becomes the result of higher energy transitions, where their oscillator strength change very rapidly within the studied range of field. For the highest aspect ratio dot, i.e. of aspect ratio 10:1, there is no any observable shift.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Clinical characteristics of patients with relapsed multiple myeloma.

AbstractAlthough survival outcomes have improved over the last decade for patients with multiple myeloma (MM), few patients remain free of disease and most inevitably relapse. Selecting a treatment for patients with relapsed MM is challenging given the number and diversity of regimens patients may have previously received, which can affect subsequent therapeutic choices. Importantly, a number of patient- and disease-related factors can also have an effect on treatment choice, treatment efficacy, and tolerability; thus, an understanding of the heterogeneity of patients in the setting of relapsed MM is important for appropriate treatment selection. Here, we review select patient and disease characteristics reported in key interventional and observational studies in relapsed MM (including age, sex, race, and the presence of high-risk disease, renal impairment, or peripheral neuropathy at baseline) to examine common and disparate features of patients with relapsed MM. As therapeutic regimens can have varying efficacy and/or tolerability in patients depending on these factors, we also provide treatment recommendations for patients with select baseline characteristics

Immune Response in Ovarian Cancer: How Is the Immune System Involved in Prognosis and Therapy: Potential for Treatment Utilization

Ovarian cancer is one of the leading causes of cancer-related death among women. Resistance to the disease occurs in more than 70% of the cases even after treated with chemotherapy agents such as paclitaxel- and platinum-based agents. The immune system is increasingly becoming a target for intense research in order to study the host's immune response against ovarian cancer. T cell populations, including NK T cells and Tregs, and cytokines have been associated with disease outcome, indicating their increasing clinical significance, having been associated with prognosis and as markers of disease progress, respectively. Harnessing the immune system capacity in order to induce antitumor response remains a major challenge. This paper examines the recent developments in our understanding of the mechanisms of development of the immune response in ovarian cancer as well as its prognostic significance and the existing experience in clinical studies

Left thoracotomy utilizing splenectomy in blunt thoracic injury: An alternative surgical approach

AbstractINTRODUCTIONPosterolateral thoracotomy could be an alternative surgical approach in selected cases coexistence of abdominal injuries with ipsilateral thoracic injury.PRESENTATION OF CASEA 65-year-old male with left sided chest injury was initially admitted to a regional health center after a crawler overthrow accident. He underwent chest tube drainage of left hemithorax and he was transferred immediately to our hospital. A CT scan showed a large spleen which was injured by a wedged splint of the 10th rib into its parenchyma. Lung parenchyma was also lacerated by chest tube misplacement with associated hemothorax. He underwent a lower left lateral thoracotomy. Splenectomy was performed via a phrenotomy and subsequently the injured lung was repaired. His postoperative course was uneventful.DISCUSSIONIncisions in the diaphragm are commonly made to provide adequate exposure during a variety of thoracic and abdominal operations. Thoracic approach could potentially be advantageous for thoracic and abdominal injuries.CONCLUSIONThoracic approach is a safe alternative, providing excellent exposure of upper abdominal organs, and should be considered in selected cases of abdominal trauma, especially when an ipsilateral thoracic injury coexists

Angiogenic cytokines profile in smoldering multiple myeloma: No difference compared to MGUS but altered compared to symptomatic myeloma

Background: Symptomatic multiple myeloma (MM) evolves from an asymptomatic precursor state termed monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM). Angiogenesis plays a key role in the pathogenesis of MM but there are very limited data for angiogenesis in SMM. Material/Methods We measured the circulating levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), vascular endothelial growth factor (VEGF), and angiogenin in 54 patients with SMM. The results were compared with those of 27 MGUS patients, 55 MM patients, and 22 healthy controls. The expression of VEGF-A gene was also evaluated in 10 patients with SMM, 10 with symptomatic MM, and 10 with MGUS. Results: The ratio of circulating Ang-1/Ang-2 was reduced in MM patients with symptomatic disease due to a dramatic increase of Ang-2 (p<0.001), but not in patients with SMM or MGUS, in whom it did not differ compared to controls. VEGF and angiogenin were increased in all patients compared to controls. However, circulating VEGF was higher in symptomatic MM compared to SMM and MGUS, while angiogenin was reduced. There were no differences in the expression of VEGF-A among the 3 patients categories. Conclusions: SMM has a circulating angiogenic cytokine profile similar to that of MGUS, but has altered profile compared to symptomatic MM. Thus, in the progression of MGUS to SMM, circulating angiogenic cytokines seem to be the same. On the contrary, in symptomatic myeloma, the alterations of angiopoietins along with VEGF contribute to myeloma cell growth, supporting the target of these molecules for the development of novel anti-myeloma agents

Optoelectronic properties of InAs GaAs columnar quantum dot laser diodes

In this thesis results are described with the aim of examining the optoelectronic properties of InAs/GaAs columnar quantum-dots and comparing them with those of more conventional self-assembled quantum-dots. The polarisation properties of a set of columnar quantum-dot samples &mdash; of varied aspect ratio and In compositional contrast between the rod-shaped dot and the surrounding 2-D layer &mdash; are studied. For this investigation a new method to obtain the ratio of the fundamental TE/TM optical response using edge photo-absorption spectroscopy is proposed, which corrects for the polarisation-dependent features of the experimental set-up. The method is verified by application to compressive and tensile strained InGaP quantum well structures, where the results are in agreement with known ratios of the band-edge matrix elements. When applied to columnar quantum-dot samples it is shown that the TE/TM optical response depends on the dot aspect ratio and the In compositional contrast. A polarisation-independent photo-absorption is illustrated for a columnar quantum-dot of an aspect ratio (dot's height over diameter) 3.51:1, which is desired for use in semiconductor optical amplifiers. For the columnar dot of an extremely high aspect ratio, 7.5:1, a room temperature TM-dominant polarisation lasing emission is observed. By studying the Quantum-Confined Stark Effect, a dramatic enhancement of the Stark shift amplitude is shown for columnar quantum-dot samples of an increased dot aspect ratio from 0.63:1 up to 1.12:1, which may have application in optical modulation/switching. For a higher aspect ratio columnar quantum-dot the shift of the band edge of the photo-absorption spectra is reduced dramatically and this has been attributed to an overall effect where the observable shift becomes the result of higher energy transitions, where their oscillator strength change very rapidly within the studied range of field. For the highest aspect ratio dot, i.e. of aspect ratio 10:1, there is no any observable shift

Olive oil intake is inversely related to cancer prevalence: a systematic review and a meta-analysis of 13800 patients and 23340 controls in 19 observational studies

Dietary fat, both in terms of quantity and quality, has been implicated to cancer development, either positively or negatively. The aim of this work was to evaluate whether olive oil or monounsaturated fat intake was associated with the development of cancer. A systematic search of relevant studies, published in English, between 1990 and March 1, 2011, was performed through a computer-assisted literature tool (i.e., Pubmed). In total 38 studies were initially allocated; of them 19 case-control studies were finally studied (13800 cancer patients and 23340 controls were included). Random effects meta-analysis was applied in order to evaluate the research hypothesis. It was found that compared with the lowest, the highest category of olive oil consumption was associated with lower odds of having any type of cancer (log odds ratio = -0.41, 95%CI -0.53, -0.29, Cohran's Q = 47.52, p = 0.0002, I-sq = 62%); the latter was irrespective of the country of origin (Mediterranean or non-Mediterranean). Moreover, olive oil consumption was associated with lower odds of developing breast cancer (logOR = -0,45 95%CI -0.78 to -0.12), and a cancer of the digestive system (logOR = -0,36 95%CI -0.50 to -0.21), compared with the lowest intake. The strength and consistency of the findings states a hypothesis about the protective role of olive oil intake on cancer risk. However, it is still unclear whether olive oil's monounsaturated fatty acid content or its antioxidant components are responsible for its beneficial effects