Review of Post-Marketing Safety Data on Tapentadol, a Centrally Acting Analgesic

<h2>Article full text</h2><p>The full text of this article can be found here <a href="https://link.springer.com/article/10.1007/s12325-017-0654-0">https://link.springer.com/article/10.1007/s12325-017-0654-0</a>.</p><h2>Provide enhanced content for this article</h2><p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”">[email protected]</a>.</p><p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p><p>Other enhanced features include, but are not limited to:</p><ul><li>Slide decks</li><li>Videos and animations</li><li>Audio abstracts</li><li>Audio slides</li></ul

Significant results of META-GSA.

<p>Significant results of META-GSA.</p

Association and correlation with gene expression in the chromosome 6p21-22 region.

<p><i>LC</i>—lung cancer, <i>SLE</i>—systemic lupus erythematosus; correlation to gene expression: pooled p-values as reported by Nguyen et al., 2014 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173339#pone.0173339.ref040" target="_blank">40</a>]; association with LC: pooled p-values as reported by Timofeeva et al. 2012 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173339#pone.0173339.ref013" target="_blank">13</a>].</p

Subgroup analysis for <i>hsa05322</i>: histological subtypes, sex, age, smoking.

<p>Subgroup analysis for <i>hsa05322</i>: histological subtypes, sex, age, smoking.</p

Markers with <0.5 in genes of interest on 6p21-22.

<p>Markers with <0.5 in genes of interest on 6p21-22.</p

Characteristics of lung cancer GWASs of the International Lung Cancer Consortium (ILCCO).

<p>Characteristics of lung cancer GWASs of the International Lung Cancer Consortium (ILCCO).</p

Study selection flow cart.

<p>Study selection flow cart.</p