Percentages of obese individuals with a poor HR-QoL domain score, according to level of hs-CRP.

<p>(A) Men. (B) Women. hs-CRP = high sensitivity C-reactive protein. The corresponding cut-off value derived from the scores in the normal weight population for the individual domains (25^th percentile men, 25^th percentile women): PF = physical functioning (95.0, 90.0); RP = role limitations due to physical health problems (100.0, 100.0); BP = bodily pain (79.6, 67.4); GH = general health (65.0, 65.0); VT = vitality (60.0, 55.0); SF = social functioning (87.5, 75.0); RE = role limitations due to emotional problems (100.0, 100.0); MH = mental health (76.0, 72.0). Mantel-Haenszel tests was used to check for a linear trend in proportions across groups of hs-CRP level within the obese population. * indicates a linear trend for individuals with obesity and higher levels of hs-CRP at <i>P</i> <0.005; ^<b>a</b><i>P</i> <0.001; and ^<b>b</b><i>P</i> <0.002.</p

Adjusted odds ratios (95% confidence intervals) for having a poor score on each domain of HR-QoL according to level of hs-CRP.

<p>Adjusted for age, BMI and the following morbidities: T2D; Pulmonary; Cancer; CVD; Head; Gastrointestinal & Liver; Kidney & Bladder; Neurological diseases</p><p>Blood disorders; Musculoskeletal diseases; Dermatological diseases and Mental disorders. Ref.: reference.</p><p>Odds ratios in bold indicate <i>P</i> <0.005</p><p>^<b>a</b><i>P</i> <0.001</p><p>^<b>b</b><i>P</i> <0.002</p><p>Adjusted odds ratios (95% confidence intervals) for having a poor score on each domain of HR-QoL according to level of hs-CRP.</p

Characteristics of participants with obesity.

<p>Data presented as mean ± SD or median (interquartile range).</p><p>^a hs-CRP measures were available in 3,173 men and 5,072 women.</p><p>BMI = body mass index; HDL = high-density lipoprotein; LDL = low-density lipoprotein; hs-CRP = high sensitivity C-reactive protein.</p><p>Characteristics of participants with obesity.</p

Adjusted odds ratios (95% confidence intervals) for having a poor score on each domain of HR-QoL according to MetS.

<p>Adjusted for age, BMI and the following morbidities: Pulmonary; Cancer; CVD; Head; Gastrointestinal & Liver; Kidney & Bladder; Neurological diseases</p><p>Blood disorders; Musculoskeletal diseases; Dermatological diseases and Mental disorders. Ref.: reference.</p><p>Odds ratios in bold indicate <i>P</i> <0.005</p><p>^<b>a</b><i>P</i> <0.001</p><p>^<b>b</b><i>P</i> <0.002</p><p>Adjusted odds ratios (95% confidence intervals) for having a poor score on each domain of HR-QoL according to MetS.</p

Percentages of obese individuals with a poor HR-QoL domain score, according to obesity grade with and without T2D.

<p>(A) Men. (B) Women. Obesity grade 1: BMI 30–34.9 kg/m² Obesity grade 2: BMI 35–39.9 kg/m² Obesity grade 3: BMI ≥40 kg/m² The corresponding cut-off value derived from the scores in the normal weight population for the individual domains (25^th percentile men, 25^th percentile women): PF = physical functioning (95.0, 90.0); RP = role limitations due to physical health problems (100.0, 100.0); BP = bodily pain (79.6, 67.4); GH = general health (65.0, 65.0); VT = vitality (60.0, 55.0); SF = social functioning (87.5, 75.0); RE = role limitations due to emotional problems (100.0, 100.0); MH = mental health (76.0, 72.0). Mantel-Haenszel tests was used to check for a linear trend in proportions across groups of obesity grade without T2D and separately for groups of obesity grade with T2D. * indicates a linear trend at <i>P</i> <0.005; ^<b>a</b><i>P</i> <0.001; and ^<b>b</b><i>P</i> <0.002.</p

Percentages of obese individuals with a poor HR-QoL domain score, according to MetS.

<p>(A) Men. (B) Women. MetS = metabolic syndrome. The corresponding cut-off value derived from the scores in the normal weight population for the individual domains (25^th percentile men, 25^th percentile women): PF = physical functioning (95.0, 90.0); RP = role limitations due to physical health problems (100.0, 100.0); BP = bodily pain (79.6, 67.4); GH = general health (65.0, 65.0); VT = vitality (60.0, 55.0); SF = social functioning (87.5, 75.0); RE = role limitations due to emotional problems (100.0, 100.0); MH = mental health (76.0, 72.0). Chi-square tests were used to analyse the differences in proportions between the obese without MetS and the obese with MetS. * indicates a difference relative to the reference group (individuals with obesity in the absence of MetS) at <i>P</i> <0.005; ^<b>a</b><i>P</i> <0.001; and ^<b>b</b><i>P</i> <0.002.</p

Z-scores for the mechanical detection threshold, mechanical pain threshold, mechanical pain sensitivity and pressure pain threshold on the lower dose and the higher dose (N = 45).

<p>Abbreviations: HC: hydrocortisone; MDT: mechanical detection threshold (P = 0.454 for the lower dose versus the higher dose); MPT: mechanical pain threshold (P = 0.800 for the lower dose versus the higher dose); MPS: mechanical pain sensitivity (P = 0.926 for the lower dose versus the higher dose); PPT: pressure pain threshold (P = 0.495 for the lower dose versus the higher dose). Data are mean ± SEM.</p

Patient flow diagram.

<p>Patient flow diagram.</p

Clinical characteristics at baseline of pituitary patients treated for adrenal insufficiency (N = 45).

<p>Clinical characteristics at baseline of pituitary patients treated for adrenal insufficiency (N = 45).</p

Five-dot patterns in parts 1 to 5 of the Ruff Figural Fluency Test.

<p>Each part consists of 35 identical five-dot patterns [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0163286#pone.0163286.ref004" target="_blank">4</a>]. See also reference 6.</p