Study of Serum Gamma Glutamyl Tranferase Levels in Female Patients with Metabolic Syndrome.

INTRODUCTION : Metabolic syndrome is a combination of Medical disorders that increase the risk of developing Cardiovascular disease and Diabetes1. It affects a great number of people and prevalence increases with age. Metabolic syndrome is also known as syndrome-X, Insulin Resistance syndrome, Raeven’s syndrome, CHAOS (Australia) or Metabo (Japan). GGT is a Potential biomarker for preclinical development of artherosclerosis because GGT was detected in atheromatous plaques of carotid and coronary arteries triggering oxidation of LDL. Signs and Symptoms : 1. Fasting Hyper glycemia – Diabetes Mellitus Type II or Impaired Fasting Glucose, Impaired Glucose tolerance or Insulin resistance, 2. High blood pressure, 3. Central obesity (Visceral, Male pattern or Apple shaped Adiposity) Over Weight with fat deposits mainly around the waist, 4. Decreased HDL – Cholesterol, 5. Elevated Triglycerides. Since GGT is Proatherogenic, it is essential to find the levels of Serum Gamma Glutamyl Transferase in individuals with Metabolic Syndrome which is Already associated with (high) cardiac risk factors. OBJECTIVE : To study the level of GGT in serum of female patients with Metabolic Syndrome. MATERIALS AND METHODS : The study was carried out in the Hypertensive Out-Patient Department of Thanjavur Medical College Hospital. The study group comprises of 100 females with Metabolic syndrome according to 3/5 criteria of National Cholesterol education programme (NCEP), in whom fasting serum levels of Gamma-Glutamyl Transferase levels were estimated. The patients were identified as having Metabolic syndrome according to the following criteria. 1. Elevated waist circumference of >or= 35 inches (88 cms), 2. Elevated Triglycerides >or=150 mg/dl, 3. Decreased HDL – Cor= 130/85 mm of Hg, 5. Elevated fasting Glucose of >or= 100mg/dl. Criteria :- Female Patients in the age group 30 to 75 yrs. Inclusion Criteria: 1. Obesity, 2. Hypertension, 3. Dyslipidemias over 150 mg/dl TAG Blood, 4. Fasting blood sugar More than 106 mg/dl, 5. HDL less than 50mg/dl. Exclusion Criteria : 1. Liver diseases, 2. Renal Diseases, 3. Alcoholism, 4. Drug in take (Anticoagulants), 5. Males (Prostatic GGT). CONCLUSION : In this study on serum GGT levels in metabolic syndrome about 56 percent showed elevation in Gamma-Glutamyl Transferease levels which may be due to Non Alcoholic Fatty Liver Disease which is the hepatic manifestation of metabolic syndrome. There is a very close relationship between low density lipoproteins, total cholesterol, triglyceride levels with serum GGT levels. Since LDL and GGT are independent risk factors for coronary heart disease, it will be very useful to describe GGT as a potential biomarker for coronary heart disease. The earlier the patients with dyslipidemia are to be investigated for elevated GGT levels and type-II diabetes mellitus. If the patients have elevated GGT levels with increased waist circumference, lifestyle modification can decrease the rate of progression to diabetes and coronary heart disease. Weight loss of 4kg over 3 years, 150 minutes of exercise per week, a low fatty and high fibre diet can be advised. Dietary recommendations for people with metabolic syndrome can be advised - eat plenty of fruits and vegetables, avoid heavily processed foods rich in salt, sugar and fat

High-Performance Computing for SKA Transient Search: Use of FPGA based Accelerators -- a brief review

This paper presents the High-Performance computing efforts with FPGA for the accelerated pulsar/transient search for the SKA. Case studies are presented from within SKA and pathfinder telescopes highlighting future opportunities. It reviews the scenario that has shifted from offline processing of the radio telescope data to digitizing several hundreds/thousands of antenna outputs over huge bandwidths, forming several 100s of beams, and processing the data in the SKA real-time pulsar search pipelines. A brief account of the different architectures of the accelerators, primarily the new generation Field Programmable Gate Array-based accelerators, showing their critical roles to achieve high-performance computing and in handling the enormous data volume problems of the SKA is presented here. It also presents the power-performance efficiency of this emerging technology and presents potential future scenarios.Comment: Accepted for JoAA, SKA Special issue on SKA (2022

Search for a high-mass dimuon resonance produced in association with b quark jets at s\sqrt{s}=13 TeV

International audienceA search for high-mass dimuon resonance production in association with one or more b quark jets is presented. The study uses proton-proton collision data collected with the CMS detector at the LHC corresponding to an integrated luminosity of 138 fb$^{-1}$ at a center-of-mass energy of 13 TeV. Model-independent limits are derived on the number of signal events with exactly one or more than one b quark jet. Results are also interpreted in a lepton-flavor-universal model with Z$'$ boson couplings to a bb quark pair ($g_\mathrm{b}$), an sb quark pair ($g_\mathrm{b}\delta_\mathrm{bs}$), and any same-flavor charged lepton ($g_\ell$) or neutrino pair ($g_\nu$), with $\left|g_{\nu}\right|=\left|g_\ell\right|$. For a Z$'$ boson with a mass $m_{\mathrm{Z}'}$ = 350 GeV (2 TeV) and $\left|\delta_\mathrm{bs}\right| \lt$ 0.25, the majority of the parameter space with 0.0057 $\lt \left|g_\ell\right| \lt$ 0.35 (0.25 $\lt \left|g_\ell\right| \lt$ 0.43) and 0.0079 $\lt \left|g_\mathrm{b}\right| \lt$ 0.46 (0.34 $\lt \left|g_\mathrm{b}\right| \lt$ 0.57) is excluded at 95% confidence level. Finally, constraints are set on a Z$'$ model with parameters consistent with low-energy b $\to$ s$\ell\ell$ measurements. In this scenario, most of the allowed parameter space is excluded for a Z$'$ boson with 350 $\lt m_{\mathrm{Z}'}\lt$ 500 GeV, while the constraints are less stringent for higher $m_{\mathrm{Z}'}$ hypotheses. This is the first dedicated search at the LHC for a high-mass dimuon resonance produced in association with multiple b quark jets, and the constraints obtained on models with this signature are the most stringent to date

Search for new physics in multijet events with at least one photon and large missing transverse momentum in proton-proton collisions at 13 TeV

International audienceA search for new physics in final states consisting of at least one photon, multiple jets, and large missing transverse momentum is presented, using proton-proton collision events at a center-of-mass energy of 13 TeV. The data correspond to an integrated luminosity of 137 fb$^{-1}$, recorded by the CMS experiment at the CERN LHC from 2016 to 2018. The events are divided into mutually exclusive bins characterized by the missing transverse momentum, the number of jets, the number of b-tagged jets, and jets consistent with the presence of hadronically decaying W, Z, or Higgs bosons. The observed data are found to be consistent with the prediction from standard model processes. The results are interpreted in the context of simplified models of pair production of supersymmetric particles via strong and electroweak interactions. Depending on the details of the signal models, gluinos and squarks of masses up to 2.35 and 1.43 TeV, respectively, and electroweakinos of masses up to 1.23 TeV are excluded at 95% confidence level

{Search for direct production of GeV-scale resonances decaying to a pair of muons in proton-proton collisions at s \sqrt{s} = 13 TeV}

A search for direct production of low-mass dimuon resonances is performed using = 13 TeV proton-proton collision data collected by the CMS experiment during the 2017–2018 operation of the CERN LHC with an integrated luminosity of 96.6 fb−1. The search exploits a dedicated high-rate trigger stream that records events with two muons with transverse momenta as low as 3 GeV but does not include the full event information. The search is performed by looking for narrow peaks in the dimuon mass spectrum in the ranges of 1.1–2.6 GeV and 4.2–7.9 GeV. No significant excess of events above the expectation from the standard model background is observed. Model-independent limits on production rates of dimuon resonances within the experimental fiducial acceptance are set. Competitive or world’s best limits are set at 90% confidence level for a minimal dark photon model and for a scenario with two Higgs doublets and an extra complex scalar singlet (2HDM+S). Values of the squared kinetic mixing coefficient ε2 in the dark photon model above 10−6 are excluded over most of the mass range of the search. In the 2HDM+S, values of the mixing angle sin(θH) above 0.08 are excluded over most of the mass range of the search with a fixed ratio of the Higgs doublets vacuum expectation tan β = 0.5