Intermittent fasting on health, aging and disease : what about sleep?

© 2020 All rights reservedImpact of intermittent fasting (IF) on health, aging and disease was recently revisited by de Cabo et al. focusing on the evidence from preclinical and clinical trials showing a broad-spectrum benefit on several health domains. Although a highly relevant and interesting critical discussion was conducted, sleep as a major factor interfering on several cardiovascular and metabolic pathways2 directly and indirectly related with those profits seems to have been forgotten.info:eu-repo/semantics/publishedVersio

How much sleep? After the normative, the clinical sense!

This work is licensed under Creative Commons Attribution 4.0 License.Since the last three decades, we care about sleep as a relevant medical issue. We actually believe, because evidence support it, that sleep is a mediator of good health. Sleep is actually a matter of survival. However, exactly how much sleep is adequate is a theme of active debate, mainly because some studies showed that either too much and too little sleep are linked to an increased risk regarding cardiovascular health and global morbidity and mortality [2]. Shorter and Longer Sleepers were stablished as normal deviations, taking account inexistent health related consequences despite shorter or longer time than the average sleep duration. Semantically we can accept this data as showing that sleep is so important that we should not jeopardize it or abuse of it. But there is much more to admire regarding the science behind these results on the adequate amount of sleep than just poetry and caution is needed because accepting non-universal facts as absolute true may sometimes really negatively impact clinical management in sleep medicine. Consensus approved that adequate amount of sleep is 7 to 9h for adults and for years several health-related authorities warned about dangers associated to the non-accomplishment to that role.info:eu-repo/semantics/publishedVersio

Poluição do ar interior : uma ligação esquecida entre o fumo, a dificuldade respiratória associada ao sono e o risco cardiometabólico

Copyright © Ordem dos Médicos 2019Recently, authors from a paper comparing the air quality in smokers’ and non-smokers’ bedrooms, using a multipollutant approach, found that several pollutants not only exceeded the limits defined by the national guidelines, but also that their concentrations were significantly higher in smokers’ bedrooms. This is an interesting and rather disturbing aspect that leads to more than a simple environmental-based reflection. It should actually be considered a broad range public health issue. Despite the generalized health related negative outcomes associated with indoor air pollution, it is perfectly established that air quality specifically affects the cardiorespiratory and metabolic functions thus increasing the risk of cardiorespiratory and metabolic disorders, both highly prevalent conditions among the general population with a non-negligible impact on mortality rates.info:eu-repo/semantics/publishedVersio

Sorgo granífero (Sorghum bicolor (L.) Moench) de alta lisina no Brasil.

Pequenas quantidades de sementes de duas linhagens de sorgo, com um gene recessivo simples para lisina, descoberto recentemente na Colecao Mundial de Sorgos da Universidade de Purdue, West Lafayette, Indiana, U.S.A., foram plantas para multiplicacao de sementes pela EMBRAPA e pela EPAMIG em Sete Lagoas, Minas Gerais. As linhagens mostraram nao adaptadas, com porte alto, maturidade tardia e susceptibilidade a doencas. Sementes geneticas de duas linhagens de alta lisina e algumas selecoes de porte baixo e precoce poderao ser requisitadas. As propriedades quimicas e biologicas do sorgo com o mutante para alta lisina foram previamente revisadas

Gerenciamento do conteúdo de projetos de pesquisa do Macroprograma 1 da Embrapa.

Este trabalho tem por objetivo apresentar o apoio que a Embrapa Informática Agropecuária tem oferecido ao Macroprograma 1 na sua gestão e no gerenciamento do conteúdo dos projetos de PD&I integrantes da sua carteira.Trabalho apresentado na V Mostra de Trabalhos de Estagiários e Bolsistas, Campinas, out. 2009

Sexsomnia and REM : predominant obstructive sleep apnea effectively treated with a mandibular advancement device

© 2016 Brazilian Association of Sleep. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).Parasomnias with sexual behavior or sexsomnias are considered a subtype of NREM parasomnias. Obstructive sleep apnea/hypopnea (OSAH) has been described as a known triggering factor for parasomnias including sexsomnia. Nasal continuous positive airway pressure (nCPAP) has been the standard of treatment for OSAH but mandibular advancement devices (MAD) are becoming an important treatment alternative. We present the case of a patient with mild OSAH and sexsomnia who had resolution of both conditions with a MAD. This patient had the added uniqueness of having REM-predominant OSAH.info:eu-repo/semantics/publishedVersio

Treatment of obstructive sleep apneas with mandibular advancement device : a preliminary study about the impact on vigilance and sleep structure

Tese de mestrado, Ciências do Sono, Faculdade de Medicina, Universidade de Lisboa, 2011Introduction: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a high prevalent and complex sleep disorder with serious consequences to individual and public health mainly because of its association with cardiovascular morbidity and mortality, sleep fragmentation and consequent excessive somnolence. The current American Academy of Sleep Medicine practice parameters recommends oral devices as a plausible option on the treatment of OSAHS. However, there is only a limited data about the efficacy of OSAHS treatment with prefabricated mandibular advancement devices (MAD) regarding to vigilance and sleep structure. Goals: The aim of this clinical prospective study was to evaluate the efficacy of a prefabricated mandibular advancement device in the treatment of OSAHS and to assess their impact on vigilance and sleep structure. Methodology: Nine patients (6 males and 3 females) with OSAHS (AHI > 5) recruited from a dental sleep consultation of a sleep clinic were referred to an attended full night polysomnographic study before and after treatment with MAD. Regarding to the therapeutic effect on OSAHS, an AHI < 5 events per hour of sleep after MAD treatment was considered to be a complete therapeutic response or therapeutic success whether an AHI < 50% from the baseline without achieving less than 5 events per hour was considered a partial response. Sleep structure and subjective sleepiness were assessed in order to evaluate the treatment efficacy. Wilcoxon matched pair test was used to test differences between baseline and follow-up. A p-value of less than 0.05 was considered significant. Results: Snoring was abolished or became inaudible in all patients as witnessed by their bed partners. There was an improvement on respiratory parameters from the baseline to the therapeutic PSG with 66.7% of patients achieving therapeutic success whereas 11.1% achieved only partial therapeutic response. Slow-wave sleep increased from 14% at the baseline to 21% after therapy with MAD and arousal index was lower after therapy (6/hr) than at baseline (16/hr) even though it was slightly above normal levels. All sleepiness scales scores and sleep complaints as well as sleep quality improved significantly after therapy compared with baseline (p<0.05). Conclusions: In this short-term study a titratable prefabricated MAD improved PSG respiratory parameters, sleep structure snoring and sleepiness in mild to moderate OSAHS patients thus supporting the use of this kind of option in OSAHS therapeutics. Future studies should focus on the comparison between a titratable prefabricated MAD with a placebo device as well as with a custom made MAD and also evaluate the long-term outcome.Introdução: A síndrome de apneia-hipopneia obstrutiva do sono (OSAHS) é uma doença do sono com elevada prevalência e complexidade que afecta de forma importante a saúde individual e a saúde pública, principalmente pela sua associação com a morbilidade e mortalidade cardiovasculares, fragmentação do sono e consequente sonolência excessiva durante o dia. As recomendações actuais da American Academy of Sleep Medicine incluem os dispositivos orais enquanto opção viável para o tratamento da SAHOS. Contudo, são limitados os dados sobre a eficácia do tratamento da SAHOS com dispositivos de avanço mandibular pré-fabricados (DAM) no que respeita à vigília e no que respeita à estrutura do sono. Objectivos: O objectivo deste estudo clínico e prospectivo foi avaliar a eficácia de um dispositivo termoplástico de avanço mandibular no tratamento da SAHOS, bem como o impacto deste na vigília e na estrutura do sono. Metodologia: Nove pacientes (6 homens e 3 mulheres) com SAHOS (IAH > 5) recrutados de uma consulta de medicina dentária numa clínica de sono foram referenciados para um estudo polisonográfico antes e após tratamento com DAM. O sucesso terapêutico foi assumido com um IAH < 5 eventos por hora de sono após tratamento com DAM enquanto uma resposta parcial foi definida por IAH < 50% da linha de base sem que tenha sido atingido um valor menor que 5 eventos por hora. Foram analisados a estrutura do sono e a sonolência de forma a avaliar a eficácia terapêutica. O teste de Wilcoxon foi usado para testar a diferença entre as condições basal e terapêutica. Um valor de p menor que 0.05 foi considerado como significativo. Resultados: O ressonar testemunhado pelos parceiros de cama foi abolido ou tornou-se inaudível em todos os pacientes. Existiu uma melhoria nos parâmetros respiratórios na PSG terapêutica comparada com a PSG basal, tendo 66.7% dos doentes atingido sucesso terapêutico enquanto 11.1% atingiram apenas resposta terapêutica. O sono de ondas lentas aumentou de 14% na condição basal para 21% após terapia com DAM e o índice de despertares foi mais baixo após tratamento (6/h) do que na condição basal (16/h) embora tenha persistido ligeiramente superior ao normal. Todas as somas relativas a escalas de sonolência resultaram numa melhoria significativa após terapêutica com DAM. Todas as melhorias foram estatisticamente significativas (p<0.05). Conclusões: Neste estudo a curto prazo, os dispositivos pré-fabricados tituláveis melhoraram, de forma significativa, os parâmetros respiratórios polissonográficos, a estrutura do sono, a roncopatia e a sonolência nos doentes com SAOS ligeira e moderada apoiando a recomendação deste tipo de dispositivos para a terapêutica da SAHOS. Estudos futuros devem focar-se na comparação de dispositivos intra-orais pré-fabricados tituláveis com placebo e com dispositivos personalizados, e na avaliação dos efeitos destes dispositivos a longo prazo

Sleepiness and cardiometabolic impact of short sleep duration and OSA : what about the clock?

© 2019 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.info:eu-repo/semantics/publishedVersio

Sistema web para análise de curvas de progresso de doenças de plantas.

A fim de minimizar o impacto de doenças em culturas, é desenvolvido um estudo baseado na análise das curvas de progresso de uma ou mais características de determinada desordem no decorrer do tempo. O estudo do comportamento dessas curvas viabiliza o entendimento do ciclo das doenças e a determinação de medidas de prevenção e manejo.Trabalho apresentado na V Mostra de Trabalhos de Estagiários e Bolsistas, Campinas, out. 2009