LNT microwave-multiphase transport model for the microwave drying of lignite thin layer

[EN] The LNT microwave-multiphase transport model has been applied to the microwave drying of lignite thin layer. Microwave energy, temperature and moisture distribution were obtained to gain a comprehensive understanding on the heat and mass transfer mechanism of the drying process. The required drying time of experiments decreased by 50, 63, 67, and 83%, respectively, with the power level rising from 119 to 700 W, while that decreased by 60, 72, 76 and 86%, respectively, for simulation results. The temperature values of the corner and edge of the lignite thin layer were higher than that of the center region, which corresponded to the microwave energy distribution. The moisture ratio profiles, temperature profiles and temperature distribution indicated good agreement between the experimental and simulation results, providing confidence in the modeling approach, which made it possible to obtain the moisture distribution successfully via simulation method.Fu, BA.; Chen, M.; Li, QH. (2018). LNT microwave-multiphase transport model for the microwave drying of lignite thin layer. En IDS 2018. 21st International Drying Symposium Proceedings. Editorial Universitat Politècnica de València. 1687-1694. https://doi.org/10.4995/IDS2018.2018.7683OCS1687169

The relationship between weight-adjusted-waist index and total bone mineral density in adults aged 20-59

IntroductionAccording to reports, obesity has a significant impact on bone health. And the weight-adjusted-waist index (WWI), superior to BMI and waist circumference (WC), is a new obesity indicator arising in recent years. This research investigated the relationship between WWI and total bone mineral density (BMD) for adults aged 20 to 59.MethodsUsing data from the 2011–2018 NHANES, we looked into the independent link between WWI and total BMD as well as its nonlinearity using weighted multiple linear regression and smooth curve fitting. Two-stage linear regression models were employed to calculate the threshold effects. There were additional subgroup analyses and testing for interactions.ResultsMultiple linear regression studies on a total of 10,372 individuals showed a significant inverse link between WWI and total BMD in adults between 20 and 59 [β = -0.04, 95% CI: (-0.04, -0.03), P<0.0001]. And smoking, race, and chronic kidney disease (CKD) had no significant effect on this negative connection (P for interaction >0.05). In addition, we found a nonlinear relationship between WWI and total BMD in diabetic and CKD patients, for which the saturation point was 11.38 cm/√kg in the CKD patient group and 10.29 cm/√kg in the diabetic patient group.ConclusionOur analysis demonstrated a significant inverse association between WWI and total BMD in adults aged 20-59

Association between dietary inflammatory index and chronic kidney disease in middle-aged and elderly populations

BackgroundA link between food-induced inflammation and common chronic diseases has been identified in studies. However, there was uncertainty about the influence of dietary inflammatory potential on the risk of chronic kidney disease (CKD) among middle-aged and older groups. Our research aimed to examine the connection between dietary inflammatory index (DII) to CKD in people aged 40 years and older.MethodsThis study comprised ten cycles of the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. Linear associations of DII with CKD, low-eGFR, and albuminuria were examined using multiple logistic regression, whereas non-linear associations were assessed by smoothed curve fitting. Besides, we conducted subgroup analyses and interaction tests.ResultsOf the 23,175 middle-aged and older individuals, a total of 5,847 suffered from CKD, making up 25.23% of all participants. After adjustment for all covariates, we found that increased DII scores were positive with an increased hazard of CKD (OR = 1.08, 95% CI: 1.05, 1.10, p < 0.0001), and the same was shown between DII and low-eGFR (OR = 1.16, 95% CI: 1.13, 1.19, p < 0.0001). After further converting DII into categorical variables, the above relationship still existed. These relations were consistent in different ages, genders, BMI, whether smoking, whether suffering from hypertension, and whether suffering from diabetes, with no significant stratification differences (all P for interaction >0.05). Surprisingly, we did not find a statistically significant correlation of DII to albuminuria after complete adjustment for covariates (OR = 1.02, 95% CI: 1.00, 1.05, p = 0.0742). Even when DII was considered as a categorical variable, this relation was still not statistically significant. Furthermore, we found an association in the shape of a U between DII and low-eGFR in the fully adjusted model, with a turning point at a DII of 1.6.ConclusionOur findings indicated that middle-aged and older persons with greater levels of DII had a significantly higher risk of CKD

UFM1-Specific Ligase 1 Ligating Enzyme 1 Mediates Milk Protein and Fat Synthesis-Related Gene Expression via the JNK Signaling Pathway in Mouse Mammary Epithelial Cells

Ubiquitin-like modifier 1 ligating enzyme 1 (UFL1) has been characterized as a ubiquitin-like (Ubl) protein that affects a range of cellular processes across various pathways. In this study, mouse mammary epithelial cells (HC11 cell line) and UFL1 knockout (KO) mice were used to establish UFL1 knockdown models to explore the influence of UFL1 on milk protein and fat synthesis in the mouse mammary gland and the underlying mechanisms. This is the first study to show UFL1 localization in mouse mammary epithelial cells. UFL1 depletion by transfected UFL1 siRNA (siUFL1) caused aggravated apoptosis. In addition, UFL1 depletion suppressed milk protein synthesis-related protein level in vivo and in vitro. Conversely, ACACA and FASN expressions increased in UFL1-deficient mice. Moreover, UFL1 depletion increased triglyceride synthesis levels and inhibited the p-JNK expression. Importantly, the expression of proteins related to milk protein synthesis was decreased in JNK- and UFL1-deficient cells, whereas proteins related to milk fat synthesis showed the opposite trend, indicating that UFL1 affects milk protein and fat synthesis via the suppression of JNK activation. Overall, our findings indicate that UFL1 plays a key role in mammary milk and fat synthesis via JNK activation

Navigation in GEO, HEO, and Lunar Trajectory Using Multi-GNSS Sidelobe Signals

Positioning of spacecraft (e.g., geostationary orbit (GEO), high elliptical orbit (HEO), and lunar trajectory) is crucial for mission completion. Instead of using ground control systems, global navigation satellite system (GNSS) can be an effective approach to provide positioning, navigation and timing service for spacecraft. In 2020, China finished the construction of the third generation of BeiDou navigation satellite system (BDS-3); this global coverage system will contribute better sidelobe signal visibility for spacecraft. Meanwhile, with more than 100 GNSS satellites, multi-GNSS navigation performance on the spacecraft is worth studying. In this paper, instead of using signal-in-space ranging errors, we simulate pseudorange observations with measurement noises varying with received signal powers. Navigation performances of BDS-3 and its combinations with other systems were conducted. Results showed that, owing to GEO and inclined geosynchronous orbit (IGSO) satellites, all three types (GEO, HEO, and lunar trajectory) of spacecraft received more signals from BDS-3 than from other navigation systems. Single point positioning (SPP) accuracy of the GEO and HEO spacecraft was 17.7 and 23.1 m, respectively, with BDS-3 data alone. Including the other three systems, i.e., GPS, Galileo, and GLONASS, improved the SPP accuracy by 36.2% and 19.9% for GEO and HEO, respectively. Navigation performance of the lunar probe was significantly improved when receiver sensitivity increased from 20 dB-Hz to 15 dB-Hz. Only dual- (BDS-3/GPS) or multi-GNSS (BDS-3, GPS, Galileo, GLONASS) could provide continuous navigation solutions with a receiver threshold of 15 dB-Hz

Exploring the real cause of hemoptysis: A case of pulmonary tumor embolism in a young woman with accompanying pulmonary metastasis of gestational trophoblastic neoplasia

Abstract We report a case of pulmonary embolism caused by gestational trophoblastic neoplasia (GTN) accompanied by pulmonary metastasis to improve the recognition ability of the disease in young female patients with pulmonary embolism and hemoptysis

Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling

Coordinated actions of Rab and Rho are necessary for numerous essential cellular processes ranging from vesicle budding to whole cell movement. How Rab and Rho are choreographed is poorly understood. Here, we report a protein complex comprised of kalirin, a Rho guanine nucleotide exchange factor (GEF) activating Rac1, and RabGEF transport protein particle (TRAPP). Kalirin was identified in a mass spectrometry analysis of proteins precipitated by trappc4 and detected on membranous organelles containing trappc4. Acute knockdown of kalirin did not affect trappc4, but significantly reduced overall and membrane-bound levels of trappc9, which specifies TRAPP toward activating Rab11. Trappc9 deficiency led to elevated expression of kalirin in neurons. Co-localization of kalirin and Rab11 occurred at a low frequency in NRK cells under steady state and was enhanced upon expressing an inactive Rab11 mutant to prohibit the dissociation of Rab11 from the kalirin-TRAPP complex. The small RNA-mediated depletion of kalirin diminished activities in cellular membranes for activating Rab11 and resulted in a shift in size of Rab11 positive structures from small to larger ones and tubulation of recycling endosomes. Our study suggests that kalirin and TRAPP form a dual GEF complex to choreograph actions of Rab11 and Rac1 at recycling endosomes

Bounds of the overflow priority classification for blocking probability approximation in OBS networks

It has been demonstrated that the overflow priority classification approximation (OPCA) is an accurate method for blocking probability evaluation for various networks and systems, including optical burst switched networks with deflection routing. OPCA is a hierarchical algorithm that requires fixed-point iterations in each layer of its hierarchy. This may imply a long running time. We prove here that the OPCA iterations alternately produce upper and lower bounds that consistently become closer to each other as more fixed-point iterations in each layer are used, and we demonstrate numerically that only a small number of iterations per layer are required for the bounds to be sufficiently close to each other. This behavior is demonstrated for various system parameters including offered load, number of channels per trunk, and maximum allowable number of deflections