Казка як текст (до проблеми структурально-семіотичної інтерпретації)

У статті розглянуто структурально - семіотичну модель інтерпретації казки. Казка представлена як специфічний культурний текст, спрямований на формування наративної й автонаративної репрезентації.The structural-semiotic model in interpre tation of fairy-tale is considered in the article. The fairy-tale is presented as an specific cultural text tends to form the narrative and autonarrative representations

Довгостроковий часовий прогноз розвитку карсту на Передкарпатті

Здійснено довгостроковий часовий прогноз активізації сульфатного карсту в Передкарпатті. В якості факторів активізації розглянуті сонячна і сейсмічна активність, метеорологічні та гідрогеологічні дані. Основою часового прогнозу, здійсненого до 2020 року, служить теорія про ритмічність природних явищ, їх взаємозв’язок і взаємообумовленість.Осуществлен временной прогноз активизации сульфатного карста в Предкарпатье. В качестве факторов активизации рассмотрены солнечная и сейсмическая активность, метеорологические и гидрогеологические данные. Основой временного прогноза, осуществленного до 2020 года является теория о ритмичности природных явлений, их взаимосвязи и взаимообусловленности.The long-term time forecast of sulfate cockpit activation throughout the Piedmont Carpathians has been accomplished. The leading factors-activators include: solar and seismic activity as well as meteorological and hydro-geological data. The backbone of this prognosis for the period up to 2020 is represented by the theory of rhythm among natural phenomena, their interconnection and stipulation

Notochordal cell-secreted factors stimulate matrix production by canine nucleus pulposus cells and bone marrow derived stromal cells

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The catabolic-to-anabolic shift seen in the canine osteoarthritic cartilage treated with knee joint distraction occurs after the distraction period

Background Cartilage regenerative mechanisms initiated by knee joint distraction (KJD) remain elusive. Animal experiments that are representative for the human osteoarthritic situation and investigate the effects of KJD at consecutive time points could be helpful in this respect but are lacking. This study investigated the effects of KJD on the osteoarthritic joint of dogs on two consecutive timepoints. Methods Osteoarthritis was bilaterally induced for 10 weeks in 12 dogs using the groove model. Subsequently, KJD was applied to the right hindlimb for 8 weeks. The cartilage, subchondral bone and synovial membrane were investigated directly after KJD treatment, and after 10 weeks of follow-up after KJD treatment. Macroscopic and microscopic joint tissue alterations were investigated using the OARSI grading system. Additionally, proteoglycan content and synthesis of the cartilage were assessed biochemically. RT-qPCR analysis was used to explore involved signaling pathways. Results Directly after KJD proteoglycan and collagen type II content were reduced accompanied by decreased proteoglycan synthesis. After 10 weeks of follow-up, proteoglycan and collagen type II content were partly restored and proteoglycan synthesis increased. RT-qPCR analysis of the cartilage suggests involvement of the TGF-β and Notch signalling pathways. Additionally, increased subchondral bone remodelling was found at 10 weeks of follow-up. Conclusion While the catabolic environment in the cartilage is still present directly after KJD, at 10 weeks of follow-up a switch towards a more anabolic joint environment was observed. Further investigation of this timepoint and the pathways involved might elucidate the regenerative mechanisms behind KJD. The Translational Potential of this Article Further elucidation of the regenerative mechanisms behind KJD could improve the existing KJD treatment. Furthermore, these findings could provide input for the discovery or improvement of other joint regenerative treatment strategies

Degenerative lumbosacral stenosis in dogs

Volume 40, Issue 5, Pages 983-1009 (September 2010) Degenerative Lumbosacral Stenosis in Dogs Björn P. Meij, DVM, PhDa, Niklas Bergknut, DVM, MSab Degenerative lumbosacral stenosis (DLSS) is the most common disorder of the caudal lumbar spine in dogs. This article reviews the management of this disorder and highlights the most important new findings of the last decade. Dogs with DLSS are typically neuro-orthopedic patients and can be presented with varying clinical signs, of which the most consistent is lumbosacral pain. Due to the availability of advanced imaging techniques such as computed tomography and magnetic resonance imaging that allow visualization of intervertebral disc degeneration, cauda equina compression, and nerve root entrapment, tailor-made treatments can be adopted for the individual patient. Current therapies include conservative treatment, decompressive surgery, and fixation-fusion of the L7-S1 junction. New insight into the biomechanics and pathobiology of DLSS and developments in minimally invasive surgical techniques will influence treatment options in the near future. There are no conflicts of interest to report and no external funding has been received. PII: S0195-5616(10)00064-1 doi:10.1016/j.cvsm.2010.05.006 © 2010 Elsevier Inc. All rights reserve