364 research outputs found
Characterizing the Blood Oxygen Level-Dependent Fluctuations in Musculoskeletal Tumours Using Functional Magnetic Resonance Imaging
This study characterized the blood oxygen level-dependent (BOLD) fluctuations in benign and malignant musculoskeletal tumours via power spectrum analyses in pre-established low-frequency bands. BOLD MRI and T1-weighted imaging (T1WI) were collected for 52 patients with musculoskeletal tumours. Three ROIs were drawn on the T1WI image in the tumours’ central regions, peripheral regions and neighbouring tissue. The power spectrum of the BOLD within each ROI was calculated and divided into the following four frequency bands: 0.01–0.027 Hz, 0.027–0.073 Hz, 0.073–0.198 Hz, and 0.198–0.25 Hz. ANOVA was conducted for each frequency band with the following two factors: the location of the region of interest (LoR, three levels: tumour “centre”, “peripheral” and “healthy tissue”) and tumour characteristic (TC, two levels: “malignant” and “benign”). There was a significant main effect of LoR in the frequencies of 0.073–0.198 Hz and 0.198–0.25 Hz. These data were further processed with post-hoc pair-wise comparisons. BOLD fluctuations at 0.073–0.198 Hz were stronger in the peripheral than central regions of the malignant tumours; however, no such difference was observed for the benign tumours. Our findings provide evidence that the BOLD signal fluctuates with spatial heterogeneity in malignant musculoskeletal tumours at the frequency band of 0.073–0.198 Hz
Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson’s Disease
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by progressive and selective death of dopaminergic neurons. Orexin-A is involved in many biological effects of the body. It has been reported that orexin-A has protective effects in cellular models of PD. However, little is known about the protective effects of orexin-A in animal parkinsonian models and the cellular mechanism has not yet been fully clarified. The aim of this study was to evaluate the effects of orexin-A in MPTP mice model of PD as well as the possible neuroprotective mechanisms of orexin-A on dopaminergic neurons. The results from animal experiments demonstrated that orexin-A attenuated the loss of dopaminergic neurons and the decrease of tyrosine hydroxylase (TH) expression in the substantia nigra, normalized the striatal dopaminergic fibers, and prevented the depletion of dopamine and its metabolites in the striatum. MPTP-treated mice showed cognitive impairments accompanied with significant motor deficiency. Orexin-A improved MPTP-induced impairments in both motor activity and spatial memory. Importantly, orexin-A increased the protein level of brain-derived neurotrophic factor (BDNF) in dopaminergic neurons of the substantia nigra. Furthermore, the protective effects of orexin-A on MPTP parkinsonian mice could be blocked by orexinergic receptor 1 (OX1R) antagonist, SB334867. In another set of experiments with SH-SY5Y dopaminergic cells, orexin-A significantly induced the expression of BDNF in a dose and time-dependent manner. The upregulation of BDNF is mainly concerned with PI3K and PKC signaling pathways via OX1R. The present study demonstrated that orexin-A exerted neuroprotective effects on MPTP parkinsonian mice, which may imply orexin-A as a potential therapeutic target for PD
Electrical Switching of the Edge Current Chirality in Quantum Anomalous Hall Insulators
A quantum anomalous Hall (QAH) insulator is a topological state of matter, in
which the interior is insulating but electrical current flows along the edges
of the sample, in either clockwise (right-handed) or counter-clockwise
(left-handed) direction dictated by the spontaneous magnetization orientation.
Such chiral edge current (CEC) eliminates any backscattering, giving rise to
quantized Hall resistance and zero longitudinal resistance. In this work, we
fabricate mesoscopic QAH sandwich (i.e. magnetic topological insulator
(TI)/TI/magnetic TI) Hall bar devices and succeed in switching the CEC
chirality in QAH insulators through spin-orbit torque (SOT) by applying a
current pulse and suitably controlled gate voltage. The well-quantized QAH
states with opposite CEC chiralities are demonstrated through four- and
three-terminal measurements before and after SOT switching. Our theoretical
calculations show that the SOT that enables the magnetization switching can be
generated by both bulk and surface carriers in QAH insulators, in good
agreement with experimental observations. Current pulse-induced switching of
the CEC chirality in QAH insulators will not only advance our knowledge in the
interplay between magnetism and topological states but also expedite easy and
instantaneous manipulation of the QAH state in proof-of-concept
energy-efficient electronic and spintronic devices as well as quantum
information applications.Comment: 24 pages, 5 figures, comments are welcom
Even-Odd Layer-Dependent Anomalous Hall Effect in Topological Magnet MnBi2Te4 Thin Films
A central theme in condensed matter physics is to create and understand the
exotic states of matter by incorporating magnetism into topological materials.
One prime example is the quantum anomalous Hall (QAH) state. Recently, MnBi2Te4
has been demonstrated to be an intrinsic magnetic topological insulator and the
QAH effect was observed in exfoliated MnBi2Te4 flakes. Here, we used molecular
beam epitaxy (MBE) to grow MnBi2Te4 films with thickness down to 1 septuple
layer (SL) and performed thickness-dependent transport measurements. We
observed a non-square hysteresis loop in the antiferromagnetic state for films
with thickness greater than 2 SL. The hysteresis loop can be separated into two
AH components. Through careful analysis, we demonstrated that one AH component
with the larger coercive field is from the dominant MnBi2Te4 phase, while the
other AH component with the smaller coercive field is from the minor Mn-doped
Bi2Te3 phase in the samples. The extracted AH component of the MnBi2Te4 phase
shows a clear even-odd layer-dependent behavior, a signature of
antiferromagnetic thin films. Our studies reveal insights on how to optimize
the MBE growth conditions to improve the quality of MnBi2Te4 films, in which
the QAH and other exotic states are predicted.Comment: 23 pages, 4 figures, comments are welcom
Late-life depression: Epidemiology, phenotype, pathogenesis and treatment before and during the COVID-19 pandemic
Late-life depression (LLD) is one of the most common mental disorders among the older adults. Population aging, social stress, and the COVID-19 pandemic have significantly affected the emotional health of older adults, resulting in a worldwide prevalence of LLD. The clinical phenotypes between LLD and adult depression differ in terms of symptoms, comorbid physical diseases, and coexisting cognitive impairments. Many pathological factors such as the imbalance of neurotransmitters, a decrease in neurotrophic factors, an increase in β-amyloid production, dysregulation of the hypothalamic-pituitary-adrenal axis, and changes in the gut microbiota, are allegedly associated with the onset of LLD. However, the exact pathogenic mechanism underlying LLD remains unclear. Traditional selective serotonin reuptake inhibitor therapy results in poor responsiveness and side effects during LLD treatment. Neuromodulation therapies and complementary and integrative therapies have been proven safe and effective for the treatment of LLD. Importantly, during the COVID-19 pandemic, modern digital health intervention technologies, including socially assistive robots and app-based interventions, have proven to be advantageous in providing personal services to patients with LLD
Original Article Unclassified renal cell carcinoma: a clinicopathological, comparative genomic hybridization, and whole-genome exon sequencing study
Abstract: Unclassified renal cell carcinoma (URCC) is a rare variant of RCC, accounting for only 3-5% of all cases. Studies on the molecular genetics of URCC are limited, and hence, we report on 2 cases of URCC analyzed using comparative genome hybridization (CGH) and the genome-wide human exon GeneChip technique to identify the genomic alterations of URCC. Both URCC patients (mean age, 72 years) presented at an advanced stage and died within 30 months post-surgery. Histologically, the URCCs were composed of undifferentiated, multinucleated, giant cells with eosinophilic cytoplasm. Immunostaining revealed that both URCC cases had strong p53 protein expression and partial expression of cluster of differentiation-10 and cytokeratin. The CGH profiles showed chromosomal imbalances in both URCC cases: gains were observed in chromosomes 1p11-12, 1q12-13, 2q20-23, 3q22-23, 8p12, and 16q11-15, whereas losses were detected on chromosomes 1q22-23, 3p12-22, 5p30-ter, 6p, 11q, 16q18-22, 17p12-14, and 20p. Compared with 18 normal renal tissues, 40 mutated genes were detected in the URCC tissues, including 32 missense and 8 silent mutations. Functional enrichment analysis revealed that the missense mutation genes were involved in 11 different biological processes and pathways, including cell cycle regulation, lipid localization and transport, neuropeptide signaling, organic ether metabolism, and ATP-binding cassette transporter signaling. Our findings indicate that URCC may be a highly aggressive cancer, and the genetic alterations identified herein may provide clues regarding the tumorigenesis of URCC and serve as a basis for the development of targeted therapies against URCC in the future
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