SPGNet: Semantic Prediction Guidance for Scene Parsing

Multi-scale context module and single-stage encoder-decoder structure are commonly employed for semantic segmentation. The multi-scale context module refers to the operations to aggregate feature responses from a large spatial extent, while the single-stage encoder-decoder structure encodes the high-level semantic information in the encoder path and recovers the boundary information in the decoder path. In contrast, multi-stage encoder-decoder networks have been widely used in human pose estimation and show superior performance than their single-stage counterpart. However, few efforts have been attempted to bring this effective design to semantic segmentation. In this work, we propose a Semantic Prediction Guidance (SPG) module which learns to re-weight the local features through the guidance from pixel-wise semantic prediction. We find that by carefully re-weighting features across stages, a two-stage encoder-decoder network coupled with our proposed SPG module can significantly outperform its one-stage counterpart with similar parameters and computations. Finally, we report experimental results on the semantic segmentation benchmark Cityscapes, in which our SPGNet attains 81.1% on the test set using only 'fine' annotations.Comment: ICCV 201

Considering agency and data granularity in the design of visualization tools

The Ecuadorian Government supports Gonzalo Gabriel Méndez through a SENESCYT scholarship.Previous research has identified trade-offs when it comes to designing visualization tools. While constructive “bottom-up” tools promote a hands-on, user-driven design process that enables a deep understanding and control of the visual mapping, automated tools are more efficient and allow people to rapidly explore complex alternative designs, often at the cost of transparency. We investigate how to design visualization tools that support a user-driven, transparent design process while enabling efficiency and automation, through a series of design workshops that looked at how both visualization experts and novices approach this problem. Participants produced a variety of solutions that range from example-based approaches expanding constructive visualization to solutions in which the visualization tool infers solutions on behalf of the designer, e.g., based on data attributes. On a higher level, these findings highlight agency and granularity as dimensions that can guide the design of visualization tools in this space.Postprin

AAPS Workshop Report: Strategies to Address Therapeutic Protein–Drug Interactions during Clinical Development

Therapeutic proteins (TPs) are increasingly combined with small molecules and/or with other TPs. However preclinical tools and in vitro test systems for assessing drug interaction potential of TPs such as monoclonal antibodies, cytokines and cytokine modulators are limited. Published data suggests that clinically relevant TP-drug interactions (TP-DI) are likely from overlap in mechanisms of action, alteration in target and/or drug-disease interaction. Clinical drug interaction studies are not routinely conducted for TPs because of the logistical constraints in study design to address pharmacokinetic (PK)- and pharmacodynamic (PD)-based interactions. Different pharmaceutical companies have developed their respective question- and/or risk-based approaches for TP-DI based on the TP mechanism of action as well as patient population. During the workshop both company strategies and regulatory perspectives were discussed in depth using case studies; knowledge gaps and best practices were subsequently identified and discussed. Understanding the functional role of target, target expression and their downstream consequences were identified as important for assessing the potential for a TP-DI. Therefore, a question-and/or risk-based approach based upon the mechanism of action and patient population was proposed as a reasonable TP-DI strategy. This field continues to evolve as companies generate additional preclinical and clinical data to improve their understanding of possible mechanisms for drug interactions. Regulatory agencies are in the process of updating their recommendations to sponsors regarding the conduct of in vitro and in vivo interaction studies for new drug applications (NDAs) and biologics license applications (BLAs)

Periodic Solution Problems for a Class of Hebbian-Type Networks with Time-Varying Delays

By using Gronwall’s inequality and coincidence degree theory, the sufficient conditions of the globally exponential stability and existence are given for a Hebbian-type network with time-varying delays. The periodic behavior phenomenon is one of the hot topics in network systems research, from which we can discover the symmetric characteristics of certain neurons. The main theorems in the present paper are illustrated using a numerical example

VisComposer: A Visual Programmable Composition Environment for Information Visualization

As the amount of data being collected has increased, the need for tools that can enable the visual exploration of data has also grown. This has led to the development of a variety of widely used programming frameworks for information visualization. Unfortunately, such frameworks demand comprehensive visualization and coding skills and require users to develop visualization from scratch. An alternative is to create interactive visualization design environments that require little to no programming. However, these tools only supports a small portion of visual forms.We present a programmable integrated development environment (IDE), VisComposer, that supports the development of expressive visualization using a drag-and-drop visual interface. VisComposer exposes the programmability by customizing desired components within a modularized visualization composition pipeline, effectively balancing the capability gap between expert coders and visualization artists. The implemented system empowers users to compose comprehensive visualizations with real-time preview and optimization features, and supports prototyping, sharing and reuse of the effects by means of an intuitive visual composer. Visual programming and textual programming integrated in our system allow users to compose more complex visual effects while retaining the simplicity of use. We demonstrate the performance of VisComposer with a variety of examples and an informal user evaluation. Keywords: Information Visualization, Visualization authoring, Interactive development environmen