Exogenous Exposure to Dihydroxyacetone Mimics High Fructose Induced Oxidative Stress and Mitochondrial Dysfunction

Dihydroxyacetone (DHA) is a three-carbon sugar that is the active ingredient in sunless tanning products and a by-product of electronic cigarette (e-cigarette) combustion. Increased use of sunless tanning products and e-cigarettes has elevated exposures to DHA through inhalation and absorption. Studies have confirmed that DHA is rapidly absorbed into cells and can enter into metabolic pathways following phosphorylation to dihydroxyacetone phosphate (DHAP), a product of fructose metabolism. Recent reports have suggested metabolic imbalance and cellular stress results from DHA exposures. However, the impact of elevated exposure to DHA on human health is currently under-investigated. We propose that exogenous exposures to DHA increase DHAP levels in cells and mimic fructose exposures to produce oxidative stress, mitochondrial dysfunction, and gene and protein expression changes. Here, we review cell line and animal model exposures to fructose to highlight similarities in the effects produced by exogenous exposures to DHA. Given the long-term health consequences of fructose exposure, this review emphasizes the pressing need to further examine DHA exposures from sunless tanning products and e-cigarettes

Atmospheric Neutrinos as a Probe of CPT Violation

We show that atmospheric neutrinos can provide a sensitive and robust probe of CPT violation (CPTV). We perform realistic event-rate calculations and study the variations of the ratio of total muon to antimuon survival rates with $L/E$ and $L$ ($L$ $\equiv$ baseline length, $E$ $\equiv$ neutrino energy) in a detector capable of identifying the muon charge. We demonstrate that measurements of these ratios when coupled with the significant $L$ and $E$ range which characterizes the atmospheric neutrino spectrum provides a method of both detecting the presence of such violations and putting bounds on them which compare very favourably with those possible from a future neutrino factory.Comment: 8 pages, 2 eps figures, modified version to appear in Phys. Lett.

Large Matter Effects in νμ→ντ{{\nu_\mu \to \nu_\tau}} Oscillations

We show that matter effects change the ${\rm {\nu_\mu \to \nu_\tau}}$ oscillation probability by as much as 70% for certain ranges of energies and pathlengths. Consequently, the ${\rm {\nu_\mu \to \nu_\mu}}$ survival probability also undergoes large changes. A proper understanding of $\nu_\mu$ survival rates must consider matter effects in $P_{\mu \tau}$ as well as $P_{\mu e}$. We comment on a) how these matter effects may be observed and the sign of $\Delta_{31}$ determined in atmospheric neutrino measurements and at neutrino factories and b) how they lead to heightened sensitivity for small $\theta_{13}$.Comment: Version to appear in Phys. Rev. Let

H-Function and a problem related to a String

The aim of this paper is to obtain the solution of a problem related to a String with the help of H–function of one variable

Problem Management Plus: An Evidence-Based Approach to Expanding Access to Community-Based Mental Health Supports

Problem Management Plus (PM+) is a proven, scalable, and cost-effective low-intensity mental health intervention that can be delivered by trained non-clinical workers for people who are experiencing common mental health conditions, such as anxiety or depression, or stressful life problems. PM+ fills a gap in the behavioral health services system by providing early intervention and potential prevention of more acute behavioral health service needs. As a model that relies on building the capacity and diversity of the behavioral health workforce, it holds promise for enhancing access to community-based mental health supports. This issue brief is designed to define and describe the PM+ intervention and its origins and identify preliminary considerations for implementing it in the United States

Mass Hierarchy Determination via future Atmospheric Neutrino Detectors

We study the problem of determination of the sign of Delta m^2_{31}, or the neutrino mass hierarchy, through observations of atmospheric neutrinos in future detectors. We consider two proposed detector types : (a) Megaton sized water Cerenkov detectors, which can measure the survival rates of nu_\mu + \bar{\nu}_\mu and nu_e + \bar{\nu}_e and (b) 100 kton sized magnetized iron detectors, which can measure the survival rates of \nu_\mu and \bar{\nu}_\mu. For energies and path-lengths relevant to atmospheric neutrinos, these rates obtain significant matter contributions from P_{\mu e}, P_{\mu \mu} and P_{ee}, leading to an appreciable sensitivity to the hierarchy. We do a binned \chi^2 analysis of simulated data in these two types of detectors which includes the effect of smearing in neutrino energy and direction and incorporates detector efficiencies and relevant statistical, theoretical and systematic errors. We also marginalize the \chi^2 over the allowed ranges of neutrino parameters in order to accurately account for their uncertainties. Finally, we compare the performance of both types of detectors vis a vis the hierarchy determination.Comment: 36 pages, 13 figures, revised version accepted in Physical Review