NON-DESTRUCTIVE RAMAN SPECTROSCOPIC METHOD FOR ESTIMATION OF MONTELUKAST FROM TABLET DOSAGES FORM

Objective: A rapid, non-destructive and non-solvent raman spectroscopic method for estimation of Montelukast from tablet dosages form Methods: Quantification was carried out by measuring the intensity of analyte peak at 1440 cm-1. Each Raman spectrum corresponded to an accumulation of 4 scans with an exposure time of 5 sec for each scan with a total integration time of 20 sec.Results: The method exhibited linearity between 2 mg-24 mg show well resolve quantification From MON. The linearity equation was calculated as y = 13.036x+70.819 and the correlation coefficient was found to be 0.997 for MON. LOD (limit of detection) and LOQ(limit of quantification) values were calculated using the calibration curve slope and standard deviation of the response. The LOD (limit of detection) and LOQ (limit of quantification) values were found to be 1.71 mg and 5.13 mg respectively.Conclusion: The developed method was successfully applied for assay of montelukast in the intact formulation. The method was validated according to an international conference on harmonisation guidelines. A recent study, montelukast sodium had been analysed by the raman method, but, looking into the tremendous potential of raman spectroscopic method; it can be extended as a process analysis and technology tool in various quality checks during manufacturing of pharmaceutical products

Comparison of haemodynamic parameters and recovery characteristics between sevoflurane and desflurane in patients undergoing day-care surgical procedure

Background: Smooth and rapid induction, optimal operating conditions and rapid recovery with minimal side effects such as nausea, vomiting, bleeding and post-operative pain are the characteristics of ideal anaesthetic. Objectives: The objective of the study was to compare the haemodynamic parameters and recovery characteristics of desflurane with sevoflurane. Materials and Methods: This was a prospective study conducted from January to December 2016. Using convenient sampling technique, a total of 40 adult patients of American Society of Anesthesiologists (ASA) physical status Grade I or II, aged between 18 and 60 years, of either sex, who were scheduled for elective day-care surgeries of <2 h duration under general anaesthesia were selected for the study after informed consent. All the patients were randomly allocated into one of the two groups using computer-generated random number table. Group I received induction with sevoflurane, while Group II was induced desflurane. Results: The baseline demographic analysis showed that the two groups did not differ significantly in age, weight, sex, ASA grade and operative times. During the course of surgery, heart rate was significantly low in Group II at 25, 30, 40 and 45 min than in Group I. Systolic and diastolic blood pressure was significantly low in group Desflurane as compared to sevoflurane. Group I showed significantly higher time for spontaneous eye opening and recalling names and recognising surroundings and post-operative complications compared to Group II. Conclusion: Desflurane has significantly better haemodynamic stability, post-operative recovery and less post-operative complications compared to sevoflurane

The effect of clonidine and tramadol on post-spinal anaesthesia shivering in hysterectomy patients: A comparative study

Introduction: Spinal anaesthesia is most commonly used as a secure anaesthetic method in elective and emergency operations. Shivering is noted in 40%–70% of patients undergoing surgery under spinal anaesthesia. The study aims to compare the efficacy, haemodynamic effects and side effects of clonidine with tramadol for the control of shivering. Materials and Methods: This prospective study was conducted from April 2016 to November 2016. Using a convenient sampling technique, a total of 60 adult patients of the American Society of Anaesthesiologists (ASA) physical status Grade I or II, aged ≥18 years, of either sex who were scheduled hysterectomy administered with clonidine vis-à -vis tramadol for spinal anaesthesia were selected for the study after informed consent. All the patients were randomly allocated into one of the two groups using computer generated random number table: Group C: Injection clonidine 75 μg slow intravenous (IV) injection and Group T: Injection tramadol 1 mg/kg slow IV injection. Results: Non-significant association was found between age, ASA grade, level of sensory block, shivering grade and mean systolic blood pressure amongst the participants of group clonidine and tramadol. Group C had significantly early control of shivering, less time for complete loss of shivering and fewer adverse events were noted compared to the tramadol group. Conclusion: Both clonidine (75 μg) and tramadol (1 mg/kg) effectively treat patients with post-spinal anaesthesia shivering, but tramadol takes longer time for complete cessation of shivering than clonidine. Clonidine offers better thermodynamics than tramadol, with fewer side effects. The more frequent incidence of the side effects of tramadol, such as nausea, vomiting and dizziness, may limit its use as an anti-shivering drug

Sub Mental Intubation in Facio-Maxillary Injury

Background: Airway management in patient with Facio-Maxillary injury is challenging due to disruption of components of upper airway, and anesthesiologist has to share the airway with the surgeons. Submental Endotracheal Intubation is safe, simple and useful technique, where oral and nasal Endotracheal Intubation cannot be performed. It avoids tracheostomy and its consequent morbidity. Here is described a case of Submental endotracheal Intubation in a 52 years old patient with panfacial trauma (FMI). He was schedule for surgical reconstruction involving Maxilo-Mandibular Fixation. Intermittent intra-operative, dental occlusion was needed to check alignment of fractured segment. Patient had nasal bone fracture and crush injury to tongue and its challenging task for an anesthesiologist to manage such airway without further damage to upper airway. Several techniques have been proposed. In this case Submental endotracheal Intubation technique for surgery with the help of surgeon was used and intra operative and post-operative period was uneventful