Synthesis and antibacterial studies on some new thiazole moiety based quinolone derivatives

1413-1415Thiazole moiety at C-3 position based quinolone derivatives have been synthesized from the starting material aniline and its derivatives. All synthesized compounds in this series have been tested for in vitro antibacterial activity against E. coli (ETEC), S. typhi, P. aeruginosa and S. aureus. All synthesized compound have been tested with reference drugs viz., norfloxacin and ciprofloxacin

Artificially designed synthetic promoter for a high level of salt induction using a cis-engineering approach

Abstract This work aimed to design a synthetic salt-inducible promoter using a cis-engineering approach. The designed promoter (PS) comprises a minimal promoter sequence for basal-level expression and upstream cis-regulatory elements (CREs) from promoters of salinity-stress-induced genes. The copy number, spacer lengths, and locations of CREs were manually determined based on their occurrence within native promoters. The initial activity profile of the synthesized PS promoter in transiently transformed N. tabacum leaves shows a seven-fold, five-fold, and four-fold increase in reporter GUS activity under salt, drought, and abscisic acid stress, respectively, at the 24-h interval, compared to the constitutive CaMV35S promoter. Analysis of gus expression in stable Arabidopsis transformants showed that the PS promoter induces over a two-fold increase in expression under drought or abscisic acid stress and a five-fold increase under salt stress at 24- and 48-h intervals, compared to the CaMV35S promoter. The promoter PS exhibits higher and more sustained activity under salt, drought, and abscisic acid stress compared to the constitutive CaMV35S

Mechanism of ruthenium(III) catalysed oxidation of some alcohols by hexacyano-ferrate( III) in mild alkaline medium

590-591Ruthenium (III) chloride catalysed oxidation of propanol-1, butanol-1, propanol-2 and butanol-2 by hexacyanoferrate (III) in sodium carbonate medium is zero order in [hexacyanoferrate (III)]. Rate of the reaction is directly proportional to [alcohol] and [OH-] in the low concentration regions. After reaching a maximum value further addition of either of these retards the rate. Increase in pH of the medium retards the rate. On the basis of the results obtained a probable reaction path has been suggested