Racial and socioeconomic disparities in triple-negative breast cancer treatment

Introduction: Triple-negative breast cancer (TNBC) continues to be a significant concern, especially among minority populations, where treatment disparities are notably pronounced. Addressing these disparities, especially among African American women and other minorities, is crucial for ensuring equitable healthcare.Areas covered: This review delves into the continuum of TNBC treatment, noting that the standard of care, previously restricted to chemotherapy, has now expanded due to emerging clinical trial results. With advances like PARP inhibitors, immunotherapy, and antibody-drug conjugates, a more personalized treatment approach is on the horizon. The review highlights innovative interventions tailored for minorities, such as utilizing technology like text messaging, smartphone apps, and targeted radio programming, coupled with church-based behavioral interventions.Expert opinion: Addressing TNBC treatment disparities demands a multifaceted approach, blending advanced medical treatments with culturally sensitive community outreach. The potential of technology, especially in the realm of promoting health awareness, is yet to be fully harnessed. As the field progresses, understanding and integrating the socio-economic, biological, and access-related challenges faced by minorities will be pivotal for achieving health equity in TNBC care

Genus Primula and its role in phytomedicine; a systematic review

Background: Primula is one of the prevalent and complex genus of family Primulaceae. Plants of Genus Primula are used in traditional medicine for treating various ailments. These plants are mostly growing in soggy meadows to alpine slopes. Various species are distributed in Pakistan, India, Indonesia, Ethiopia and South America. Purpose: This review is presented to provides up-to-date research progress in, phytochemistry, pharmacology of Genus Primula. It provides a strong basis for future scientific research in phytomedicine. Method: The relevant literature on Genus Primula was collected by resources i.e., scientific databases including Pubmed, Google Scholar, Google, ACS, Sci hub, Web of science, Science Direct databases and Encyclopedia. Results: Traditionally plants are used to treat eye aliments, respiratory tract infections, headache, epileptic seizures, insomnia, skin problems, ulcers, urinary disorders, expectorant and wound healing process etc. Alkaloids, flavonoids, flavones, glycosides, saponins, sapogenins, tannins, quinolones, terpenes, polysaccharides, volatile oils, coumarins, fatty acid, fatty alcohols, phytosterols, sugar alcohol, miconidin, fatty acid ester and unsaturated higher fatty acids are the medicinally important phytoconstituents of genus species of Primula. Pharmacological studies have shown their prominent biological activities such as antibacterial, antioxidant, antidiabetic, antiviral, antileishmanial, antiepileptic, anticancer, cardioprotactive, antiproliferative, anxiolytic, and contraceptive. Conclusion: Species of genus Primula are widely employed in traditional medicine system. It contains potential phytoconstituents which are being used in modern pharmacological research area. This review revealed that primulas are important medicinal plants and have pivotal role in phytomedicine

Starlike Functions Associated with Bernoulli’s Numbers of Second Kind

The aim of this paper is to introduce a class of starlike functions that are related to Bernoulli’s numbers of the second kind. Let φBS(ξ)=ξeξ−12=∑n=0∞ξnBn2n!, where the coefficients of Bn2 are Bernoulli numbers of the second kind. Then, we introduce a subclass of starlike functions such that ξ′(ξ)(ξ)≺φBS(ξ). We found out the coefficient bounds, several radii problems, structural formulas, and inclusion relations. We also found sharp Hankel determinant problems of this class

Inflammatory bowel disease and associated cardiovascular disease outcomes: a systematic review

Background: There is limited and conflicting data available regarding the cardiovascular disease outcomes associated with inflammatory bowel disease (IBD). Objective: We aim to perform a systematic review to evaluate the cardiovascular outcomes and mortality associated with IBD patients. Methods: A systematic literature search has been performed on PubMed, Embase, Cochrane, and Scopus from inception till May 2022 without any language restrictions. Results: A total of 2,029,941 patients were included in the analysis from 16 studies. The mean age of the patients was 45.6 years. More females were found compared with males (57% vs 43%). The most common risk factors for cardiovascular disease (CVD) included smoking (24.19%) and alcohol (4.60%). The most common comorbidities includes hypertension (30%), diabetes mellitus (14.41%), dyslipidemia (18.42%), previous CVD (22%), and renal disease (10%). Among outcomes, all-cause mortality among IBD patients was 1.66%; ulcerative colitis (UC): 15.92%; and Crohn disease (CD): 0.30%. Myocardial Infarction (MI) among IBD patients were 1.47%, UC: 30.96%; and CD: 34.14%. CVD events among IBD patients were 1.95%. Heart failure events among IBD patients were 5.49%, stroke events among IBD patients were 0.95%, UC: 2.63%, and CD: 2.41%, respectively. Conclusion: IBD patients are at higher risk for adverse cardiovascular outcomes, especially in women. Although there remains a lack of concrete treatment algorithms and assessment parameters that better characterize IBD risk factors, nutritional modifications and physical activity should be at the forefront of CVD prevention in IBD.</p