1 research outputs found
Magnetic Mesoporous Silica Gated with Doped Carbon Dot for Site-Specific Drug Delivery, Fluorescence, and MR Imaging
Construction
of a theranostic agent which integrates multiple modalities
with different functions into one entity is challenging from a molecular
design and synthesis perspective. In this context, the present paper
reports the fabrication of a novel type of multifunctional hybrid
nanoparticle composed of magnetic gadolinium oxide–iron oxide
core, mesoporous silica shell gated with boronic acid functionalized
highly luminescent carbon quantum dot (BNSCQD). The porous silica
shell acts as an excellent reservoir for anticancer drug 5-fluorouracil,
whereas the BNSCQD cap impressively controls the drug transport under
simulated intracellular environment. Furthermore, recognition and
fluorescence turn on response of BNSCQD toward cell surface glycan
sialyl Lewis<sup>a</sup> (SL<sup>a</sup>) enables targeted drug release
and excellent fluorescence imaging of SL<sup>a</sup> overexpressed
HePG2 cancer cells. The <i>r</i><sub>1</sub> and <i>r</i><sub>2</sub> relaxivities of the material are found to
be 10 and 165 mM<sup>–1</sup> s<sup>–1</sup> which is
comparable to commercially available magnetic resonance imaging contrast
agents. Benefiting from the combined advantages of dual stimuli-responsive
drug release, excellent optical imaging, and MR imaging, this novel
construct can be a promising theranostic material