Comparison Of Ranolazine With Telmisartan In The Treatment Of Mild To Moderate Hypertension

The objective of the present study was to develop and compare fast-dissolving oral films of Anti-Hypertensive drugs Ranolazine and Telmisartan using a solvent casting technique.  A response surface methodology experimental design was applied to optimize fast-dissolving film using Box-Behnken experimental design. The concentrations of X1 (mango kernel, 100–400 mg), X2 (MDX 0–100 mg), and X3 (PG, 15–30%) were preferred as independent factors for Ranolazine films. The concentrations of X1 (Mango kernel, 100–300 mg), X2 (Maltodextrin, 200–350 mg), and X3 (Propylene glycol, 15–30%) were selected as independent variables for Telmisartan.  Y1 (Tensile Strength; MPa), Y2 (Disintegration Time; Sec), Y3 (Folding Endurance; Folds), Y4 (Elongation; %), and Y5 (% drug release; min) were considered as dependent variables for both drugs. Various physicochemical parameters like weight variation, thickness, folding endurance, and drug content were evaluated. Ranolazine films' maximum bio-adhesive strength and highest ex-vivo mucoadhesion time were 52.43±0.31 gm and 182 min observed for F6. Telmisartan-optimized films F4 had the highest ex-vivo mucoadhesion duration and maximal bioadhesive strength of 49.82 gm and 189 min, respectively. Ex-vivo muco irritation was performed by using fresh sheep oral mucosa.  The Pharmacokinetic plasma parameters of Telmisartan-optimized films F4 results displayed improved absorption compared to RZ-OFDFs F6