Foreword : evolution in the century of biology

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Effect of tenure legislation in the schools

Thesis (M.A.)--Boston University, 1932. This item was digitized by the Internet Archive

Investigating Chemotherapeutic Resistance: Why is Glioblastoma So Deadly?

Glioblastoma multiforme (GBM), a malignancy of the glioblast stem cells of the brain, is one of the most aggressive and untreated forms of brain cancer. When an individual is diagnosed with GBM, depending on the location of the tumor, there are three treatment options including surgery, radiation, chemotherapy or the combination of these treatments. Many patients choose chemotherapy, however most GBM cases show little to no response to Temozolomide (TMZ), which is a common chemotherapy drug used for this type of cancer. In some recent studies, researchers have noticed an elevated amount or over production of an enzyme, Inosine 5\u27-monophosphate dehydrogenase (IMPDH). This enzyme 31 helps with DNA repair but in many GBM cases, due to its over production, it repairs at such a fast rate it does not allow TMZ to terminate the cancerous tumors. In our research we have been investigating whether the chemotherapeutic agent causes the increase in expression directly or whether it is a unique property of this cell type. Future directions involve: determining a molecular pathway that could lead to IMPDH expression at such high levels under chemotherapeutic stress and whether co-administering IMPDH inhibitors with TMZ can improve prognosis for those suffering from GBM.https://openriver.winona.edu/urc2019/1023/thumbnail.jp

DNA sonification for public engagement in bioinformatics

Funding: This work was funded by the Science and Technology Facilities Council (STFC) grant numbers ST/R000328/1 and ST/T000872/1.Objective: Visualisation methods, primarily color-coded representation of sequence data, have been a predominant means of representation of DNA data. Algorithmic conversion of DNA sequence data to sound – sonification – represents an alternative means of representation that uses a different range of human sensory perception. We propose that sonification has value for public engagement with DNA sequence information because it has potential to be entertaining as well as informative. We conduct preliminary work to explore the potential of DNA sequence sonification in public engagement with bioinformatics. We apply a simple sonification technique for DNA, in which each DNA base is represented by a specific note. Additionally, a beat may be added to indicate codon boundaries or for musical effect. We report a brief analysis from public engagement events we conducted that featured this method of sonification. Results: We report on use of DNA sequence sonification at two public events. Sonification has potential in public engagement with bioinformatics, both as a means of data representation and as a means to attract audience to a drop-in stand. We also discuss further directions for research on integration of sonification into bioinformatics public engagement and education.Publisher PDFPeer reviewe

"Darkwater's Existentialist Socialism"

This paper examines W.E.B. Du Bois's Darkwater as an existentialist text offering a conception of socialism best characterized as Africana existentialist socialism. It argues for a conception of Africana existentialism as inclusive of issues of collective, and not solely individual responsibility. Darkwater is interpreted in terms of a unifying thematic of a humanist anti-theodicy, our of which emerges Du Bois's conception of an ideal of "service without servants." This socialistic ideal is in turn worked out in relation to the figure of "the Immortal Child.