Scalable and Robust Inference of Sparse Brain Signals via Personalized Physiological System Identification

Electrodermal activities (EDA) are any electrical phenomena observed on the skin. Skin conductance (SC), a measure of EDA, shows fluctuations due to autonomic nervous system (ANS) activation induced sweat secretion. Since it can capture psychological and physiological information, there is a significant rise in the research for tracking mental and physiological health with SC recording. SC signal that is an observation of the EDA dynamics is representative of the class of signals generated by sparse dynamic systems. These signals can be deconvolved to uncover hidden variables. However, the current state-of-the-art of system theoretic deconvolution and consequent investigation has many challenges. The challenges include the need for a framework that incorporates prior physiological knowledge, the absence of a robust inference framework that can reliably fuse multichannel observations, and the non-convexity of the parameter estimation optimization problem. In addition to that, there is a lack of a comprehensive physiologically motivated model, the existing deconvolution method has poor scalability, and there is the presence of motion artifacts. Therefore, firstly, we model the fast varying fluctuations, i.e., the phasic component of SC using a two-dimensional state-space model representing the diffusion and evaporation processes of sweating with a sparse impulsive signal as the input representing ANS activation. We model the slowly varying fluctuation, i.e., the tonic component of SC with several cubic B-spline functions. We formulate an optimization problem with physiological priors on system parameters, a sparsity prior on the neural stimuli, and a smoothness prior on the tonic component. Finally, we employ a generalized cross-validation-based coordinate descent approach to balance the smoothness of the tonic component, the sparsity of the neural stimuli, and the residual. Secondly, we propose a model that combines multichannel SC recording that relates to the impulsive sparse ANS activation. Then we introduce a generalized cross validation-based deconvolution approach utilizing this model. Thirdly, we utilize the continuous system identification technique to reformulate the cost function as a convex one for the deconvolution problem. Fourthly, we propose a comprehensive model for the SC dynamics. The proposed model is a 3D state-space representation of the direct secretion of sweat via pore opening and diffusion followed by corresponding evaporation and reabsorption. The comprehensive model enables us to derive a scalable fixed interval smoother-based sparse deconvolution approach for scalable ANS activation inference. We incorporate generalized cross-validation to tune the sparsity level. Finally, we propose a motion artifact reduction scheme that leverages multiresolution linear/nonlinear adaptive filters and three-axis accelerometer-based motion reference. We further perform experiments to obtain the motion artifact contaminated data and the corresponding motion reference signal for validating the proposed scheme. For evaluation, we utilize both experimental, publicly available, and simulated datasets to investigate the performance of our proposed schemes. Our results show that our approach is successfully recovering ANS activation from SC recordings by addressing the existing challenges. Furthermore, we validate our approaches for reliability, robustness, and scalability by evaluating their event SC response detection performance. Finally, our results validate that our physiology-motivated state-space model can comprehensively explain the EDA dynamics and outperforms all previous approaches. Our findings introduce a whole new perspective and have a broader impact on the standard practices of EDA analysis and the analysis of similar systems with sparse dynamics

Inferring Autonomic Nervous System Activation from Noisy Wearable Electrodermal Activity Data with the Goal of Investigating the Relationship Between Vocal Hyperfunction and Emotional Arousal

Vocal hyperfunction is a condition characterized by chronically excessive or unbalanced vocal muscle recruitment. Patients with non-phonotraumatic vocal hyperfunction experience higher than normal levels of psychological stress when speaking, which could imply a relationship between high arousal and vocal hyperfunction. As such, investigating the relationship between arousal level and voice activity may provide insights into the prevention, diagnosis and treatment of vocal hyperfunction. Arousal information can be inferred from eletrodermal activity data. As a measure of electrodermal activity, skin conductance reflects the stimulation from the autonomic nervous system on eccrine sweat glands due to arousal. However, extracting neural stimuli from skin conductance measurements is challenging, as the underlying physiological system is unknown. Moreover, artifacts originating in real-world settings can corrupt the skin conductance signal, making portions of the signal unsuitable for analysis. We investigate two published automatic methods for identifying electrodermal activity segments suitable for analysis. We also visually inspect the data and compare with automatic methods. Of the current methods available for identifying suitable regions of electrodermal activity data for analysis, visually selecting regions is the most reliable and the most conservative. Then, we isolate the satisfactory segments of electrodermal activity data for analysis. Using a generalized-cross-validation-based block coordinate descent approach for sparse deconvolution, we recover underlying neural stimuli and model parameters from the skin conductance signal. In future work, we plan to investigate the relationship between voice data and the underlying neural stimuli and model parameters recovered from electrodermal activity data. This project was completed with contributions from Andrew J. Ortiz and Daryush D. Mehta from Massachusetts General Hospital.Electrical and Computer Engineering, Department ofHonors Colleg

Regulation of brain cognitive states through auditory, gustatory, and olfactory stimulation with wearable monitoring

Abstract Inspired by advances in wearable technologies, we design and perform human-subject experiments. We aim to investigate the effects of applying safe actuation (i.e., auditory, gustatory, and olfactory) for the purpose of regulating cognitive arousal and enhancing the performance states. In two proposed experiments, subjects are asked to perform a working memory experiment called n-back tasks. Next, we incorporate listening to different types of music, drinking coffee, and smelling perfume as safe actuators. We employ signal processing methods to seamlessly infer participants’ brain cognitive states. The results demonstrate the effectiveness of the proposed safe actuation in regulating the arousal state and enhancing performance levels. Employing only wearable devices for human monitoring and using safe actuation intervention are the key components of the proposed experiments. Our dataset fills the existing gap of the lack of publicly available datasets for the self-management of internal brain states using wearable devices and safe everyday actuators. This dataset enables further machine learning and system identification investigations to facilitate future smart work environments. This would lead us to the ultimate idea of developing practical automated personalized closed-loop architectures for managing internal brain states and enhancing the quality of life

Regulation of brain cognitive states through auditory, gustatory, and olfactory stimulation with wearable monitoring

Inspired by advances in wearable technologies, we design and perform human-subject experiments. We aim to investigate the effects of applying safe actuation (i.e., auditory, gustatory, and olfactory) for the purpose of regulating cognitive arousal and enhancing the performance states. In two proposed experiments, subjects are asked to perform a working memory experiment called n-back tasks. Next, we incorporate listening to different types of music, drinking coffee, and smelling perfume as safe actuators. We employ signal processing methods to seamlessly infer participants' brain cognitive states. The results demonstrate the effectiveness of the proposed safe actuation in regulating the arousal state and enhancing performance levels. Employing only wearable devices for human monitoring and using safe actuation intervention are the key components of the proposed experiments. Our dataset fills the existing gap of the lack of publicly available datasets for the self-management of internal brain states using wearable devices and safe everyday actuators. This dataset enables further machine learning and system identification investigations to facilitate future smart work environments. This would lead us to the ultimate idea of developing practical automated personalized closed-loop architectures for managing internal brain states and enhancing the quality of life