Bis[trans-dichloridobis(propane-1,3-diamine-κ2 N,N′)chromium(III)] tetra­chloridozincate determined using synchrotron radiation

In the title compound, [CrCl2(C3H10N2)2]2[ZnCl4], the CrIII atom is coordinated by four N atoms of propane-1,3-diamine (tn) and two Cl atoms in a trans arrangement, displaying a distorted octa­hedral geometry with crystallographic inversion symmetry; the Zn atom in the [ZnCl4]2− anion lies on a -4 axis. The orientations of the two six-membered chelate rings in the complex cation are in an anti chair–chair conformation with respect to each other. The Cr—N bond lengths are 2.087 (6) and 2.097 (6) Å. The Cr—Cl and Zn—Cl bond lengths are 2.3151 (16) and 2.3255 (13) Å, respectively. Weak inter­molecular hydrogen bonds involving the tn NH2 groups as donors and chloride ligands of the anion and cation as acceptors are observed

{3,14-Dimethyl-2,6,13,17-tetra­aza­tricyclo­[16.4.0.07,12]docosane-κ4 N,N′,N′′,N′′′)bis­(nitrato-κO)copper(II)

The CuII atom in the title compound, [Cu(NO3)2(C20H40N4)], is N,N′,N′′,N′′′-chelated by the macrocyclic ligand: the four N atoms form a square, above and below which are located the O atoms of the nitrate ions. The metal atom exists in a tetra­gonally distorted octa­hedron, on a special position of site symmetry. One of the amino groups is hydrogen bonded to an O atom of the nitrate ion. The other amino group is hydrogen bonded to O atom of an adjacent mol­ecule, generating a supra­molecular dimeric hydrogen-bonded dinuclear aggregate

2,13-Dibenzyl-5,16-diethyl-2,6,13,17-tetra­aza­tricyclo­[16.4.0.07,12]docosan-2-ium nitrate

One of the tertiary amine atoms has been protonated in the title salt, C36H57N4 +·NO3 −. The four N atoms of the macrocycle are almost coplanar (r.m.s. deviation = 0.0053 Å), a result correlated with the formation of intra­molecular N—H⋯N and N—H⋯(N,N) hydrogen bonds. With respect to this plane, the benzyl groups lie to either side; a similar arrangement pertains for the cyclo­hexyl rings (each with a chair conformation). Helical supra­molecular chains are evident in the crystal, whereby alternating cations and anions are linked by C—H⋯O inter­actions. The chains are consolidated into supra­molecular arrays in the ab plane via C—H⋯π contacts involving both benzene rings

Biopolymer-Based Nanosystems for siRNA Drug Delivery to Solid Tumors including Breast Cancer

Nanobiopolymers such as chitosan, gelatin, hyaluronic acid, polyglutamic acid, lipids, peptides, exosomes, etc., delivery systems have prospects to help overwhelmed physiological difficulties allied with the delivery of siRNA drugs to solid tumors, including breast cancer cells. Nanobiopolymers have favorable stimuli-responsive properties and therefore can be utilized to improve siRNA delivery platforms to undruggable MDR metastatic cancer cells. These biopolymeric siRNA drugs can shield drugs from pH degradation, extracellular trafficking, and nontargeted binding sites and are consequently suitable for drug internalization in a controlled-release fashion. In this review, the utilization of numerous biopolymeric compounds such as siRNA drug delivery systems for MDR solid tumors, including breast cancers, will be discussed

3,14-Diethyl-2,13-diaza-6,17-diazoniatricyclo[16.4.0.07,12]docosane dichloride tetrahydrate from synchrotron radiation

The asymmetric unit of title hydrated salt, C22H46N42+·2Cl−·4H2O, comprises half a centrosymmetric dication, one Cl− anion and two water molecules of crystallization. The structure determination reveals that protonation has occurred at diagonally opposite amine N atoms, and that the dication features intramolecular N—H...N hydrogen bonds. In the crystal, a three-dimensional artchitecture is formed by O—H...Cl/N and N—H...Cl/O hydrogen bonds

Industrial Manufacturing Applications of Zinc Oxide Nanomaterials: A Comprehensive Study

Nanomaterials (NMs) that are created with zinc oxide are very valuable for a wide variety of applications. There is a present interest in ZnO nanoparticles in a wide range of industries. This interest may be attributed to the fact that ZnO NPs have many important features. It will be necessary for ZnO NPs to possess certain qualities in order for them to rapidly find uses in industry and for these applications to have an effect on the expansion of the economy. A large surface area, a large bandgap, photocatalytic property, biosensing, bioimaging, and other qualities are included in this list. In this article, the extraordinary characteristics of ZnO NPs, as well as their novel applications in industrial settings and the challenges that come along with their utilization, will be discussed

Recent Advances in Tumor Targeting via EPR Effect for Cancer Treatment

Cancer causes the second-highest rate of death world-wide. A major shortcoming inherent in most of anticancer drugs is their lack of tumor selectivity. Nanodrugs for cancer therapy administered intravenously escape renal clearance, are unable to penetrate through tight endothelial junctions of normal blood vessels and remain at a high level in plasma. Over time, the concentration of nanodrugs builds up in tumors due to the EPR effect, reaching several times higher than that of plasma due to the lack of lymphatic drainage. This review will address in detail the progress and prospects of tumor-targeting via EPR effect for cancer therapy