Start-to-end modelling of a mode-locked optical klystron free electron laser amplifier

A free electron laser (FEL) in a mode-locked optical klystron (MLOK) configuration is modelled using start-to-end simulations that simulate realistic electron beam acceleration and transport before input into a full three-dimensional FEL simulation code. These simulations demonstrate that the MLOK scheme is compatible with the present generation of radiofrequency accelerator designs. A train of few-optical cycle pulses is predicted with peak powers similar to those of the equivalent conventional FEL amplifier. The role of electron beam energy modulation in these results is explained and the limitations of some simulation codes discussed. It is shown how seeding the FEL interaction using a High Harmonic seed laser can improve the coherence properties of the output

Predictors of normotension on withdrawal of antihypertensive drugs in elderly patients: prospective study in second Australian national blood pressure study cohort

Objectives: To identify simple long term predictors of maintenance of normotension after withdrawal of antihypertensive drugs in elderly patients in general practice. Design: Prospective cohort study. Setting: 169 general practices in Victoria, Australia. Participants: 503 patients aged 65-84 with treated hypertension who were withdrawn from all antihypertensive drugs and remained drug free and normotensive for an initial two week period; all were followed for a further 12 months. Main outcome measures: Relative likelihood of maintaining normotension 12 months after drug withdrawal; relative likelihood of early return to hypertension after drug withdrawal. Results: The likelihood of remaining normotensive at 12 months was greater among younger patients (65-74 years), patients with lower "on-treatment" systolic blood pressure, patients on single agent treatment, and patients with a greater waist:hip ratio. The likelihood of return to hypertension was greatest for patients with higher "on-treatment" systolic blood pressure. Conclusions: Age, blood pressure control, and the number of antihypertensive drugs are important factors in the clinical decision to withdraw drug treatment. Because of consistent rates of return to antihypertensive treatment, all patients from whom such treatment is withdrawn should be monitored indefinitely to detect a recurrence of hypertension.Mark R Nelson, Chris M Reid, Henry Krum, Tui Muir, Philip Ryan, John J McNei

Recent Decisions

Comments on recent decisions by Norman H. McNeil, David N. McBride, Robert J. Hepler, John P. Coyne, and Allan Schmid

Capital allocation for credit portfolios with kernel estimators

Determining contributions by sub-portfolios or single exposures to portfolio-wide economic capital for credit risk is an important risk measurement task. Often economic capital is measured as Value-at-Risk (VaR) of the portfolio loss distribution. For many of the credit portfolio risk models used in practice, the VaR contributions then have to be estimated from Monte Carlo samples. In the context of a partly continuous loss distribution (i.e. continuous except for a positive point mass on zero), we investigate how to combine kernel estimation methods with importance sampling to achieve more efficient (i.e. less volatile) estimation of VaR contributions.Comment: 22 pages, 12 tables, 1 figure, some amendment

Factors Influencing Bike Share Among Underserved Populations: Evidence from Three US Cities

There is evidence that lower-income and people of color (POC) in the U.S. do not use bike share as much as higher-income and white people. Using data from residents living near stations in New York, Chicago, and Philadelphia, our analysis examines reasons for these disparities. While smaller shares of POC are members (vs higher-income white people), large shares of POC are interested in bike share. Among POC, having positive attitudes about bicycling and having family and friends that use bike share are strong predictors of interest in bike share. POC are also motivated to use bike share for recreational reasons. Receiving information from interactive sources may be effective at increasing bike share use and interest, though it is not clear whether these efforts have affected POC. Cost is a barrier for people who have tried bike share and are interested in using it in the future but are not members

A nonparametric urn-based approach to interacting failing systems with an application to credit risk modeling

In this paper we propose a new nonparametric approach to interacting failing systems (FS), that is systems whose probability of failure is not negligible in a fixed time horizon, a typical example being firms and financial bonds. The main purpose when studying a FS is to calculate the probability of default and the distribution of the number of failures that may occur during the observation period. A model used to study a failing system is defined default model. In particular, we present a general recursive model constructed by the means of inter- acting urns. After introducing the theoretical model and its properties we show a first application to credit risk modeling, showing how to assess the idiosyncratic probability of default of an obligor and the joint probability of failure of a set of obligors in a portfolio of risks, that are divided into reliability classes

Differential effects of nutritional folic acid deficiency and moderate hyperhomocysteinemia on aortic plaque formation and genome-wide DNA methylation in vascular tissue from ApoE-/- mice

Low folate intake is associated with vascular disease. Causality has been attributed to hyperhomocysteinemia. However, human intervention trials have failed to show the benefit of homocysteine-lowering therapies. Alternatively, low folate may promote vascular disease by deregulating DNA methylation. We investigated whether folate could alter DNA methylation and atherosclerosis in ApoE null mice. Mice were fed one of six diets (n = 20 per group) for 16 weeks. Basal diets were either control (C; 4% lard) or high fat (HF; 21% lard and cholesterol, 0.15%) with different B-vitamin compositions: (1) folic acid and B-vitamin replete, (2) folic acid deficient (−F), (3) folic acid, B6 and B12 deficient (−F−B). −F diets decreased plasma (up to 85%; P < 0.05), whole blood (up to 70%; P < 0.05), and liver folate (up to 65%; P < 0.05) and hepatic SAM/SAH (up to 80%; P < 0.05). −F−B diets reduced plasma (up to 76%; P < 0.05), whole blood (up to 72%; P < 0.05), and liver B12 (up to 39%; P < 0.05) and hepatic SAM/SAH (up to 90%; P < 0.05). −F increased homocysteine 2-fold, while −F−B increased homocysteine 3.6- and 6.8-fold in the C and HF groups (P < 0.05). Plaque formation was increased 2-fold (P < 0.0001) in mice fed a HF diet. Feeding a HF–F diet increased lesion formation by 17% (P < 0.05). There was no change in 5-methyldeoxycytidine in liver or vascular tissue (aorta, periadventitial tissue and heart). These data suggest that atherogenesis is not associated with genome-wide epigenetic changes in this animal model