Disability in young people and adults after head injury: 12-14 year follow up of a prospective cohort

Background: There is a need to establish how long term outcome evolves after head injury (HI) and factors related to this, to inform opportunities for intervention. Objective: To determine late outcome in adults 12-14 years after hospital admission for HI and to examine relationships between injury, early and late factors and disability. Methods: A prospective cohort with HI, whose outcome was reported previously at 1 and 5-7 years after injury were followed up after 12-14 years. Participants were assessed using structured and validated measures of disability (Glasgow Outcome Scale-Extended), psychological well-being, alcohol use and health status. Results: Of 219 survivors followed-up at 5-7 years, 34 (15.5%) had died by 12-14 years. Disability remained common in survivors at 12-14 years (51%), as found at one and 5-7 years (53%). For those disabled at 1 year, outcome was dismal, with 80% dead or disabled at 12-14 years. Older age at injury, a premorbid history of brain illness or physical disability and post-injury low self-esteem and stress were associated with disability at 12-14 years. Disability changed between 5-7 and 12-14 years in 55% of survivors, improving in 23%. Late changes in disability between 5-7 and 12-14 years were associated with self-perceptions of locus of control as being 'powerful others' at 5-7 years. Conclusions: Disability is common 12-14 years after hospital admission with a head injury. For some there is a dynamic process of change in disability over time that is associated with self-perceptions of control that could be a target for intervention based research

Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancer

The presence of systemic inflammation before surgery, as evidenced by the glasgow prognostic score (mGPS), predicts poor long-term survival in colorectal cancer. The aim was to examine the relationship between the preoperative mGPS and the development of postoperative complications in patients undergoing potentially curative resection for colorectal cancer. Patients (n=455) who underwent potentially curative resections between 2003 and 2007 were assessed consecutively, and details were recorded in a database. The majority of patients presented for elective surgery (85%) were over the age of 65 years (70%), were male (58%), were deprived (53%), and had TNM stage I/II disease (61%), had preoperative haemoglobin (56%), white cell count (87%) and mGPS 0 (58%) in the normal range. After surgery, 86 (19%) patients developed a postoperative complication; 70 (81%) of which were infectious complications. On multivariate analysis, peritoneal soiling (P<0.01), elevated preoperative white cell count (P<0.05) and mGPS (P<0.01) were independently associated with increased risk of developing a postoperative infection. In elective patients, only the mGPS (OR=1.75, 95% CI=1.17-2.63, P=0.007) was significantly associated with increased risk of developing a postoperative infection. Preoperative elevated mGPS predicts increased postoperative infectious complications in patients undergoing potentially curative resection for colorectal cancer

Optical monitoring of gamma-ray source fields

The three gamma-ray burst source fields GBS1028+46, GBS1205+24, and GBS2252-03 have been monitored for transient optical emission for a combined total of 52 hours. No optical events were seen. The limiting magnitude for the search was M sub V = 15.8 longer and M sub V = 17.0 for 6.0 s or longer

Using Flow Specifications of Parameterized Cache Coherence Protocols for Verifying Deadlock Freedom

We consider the problem of verifying deadlock freedom for symmetric cache coherence protocols. In particular, we focus on a specific form of deadlock which is useful for the cache coherence protocol domain and consistent with the internal definition of deadlock in the Murphi model checker: we refer to this deadlock as a system- wide deadlock (s-deadlock). In s-deadlock, the entire system gets blocked and is unable to make any transition. Cache coherence protocols consist of N symmetric cache agents, where N is an unbounded parameter; thus the verification of s-deadlock freedom is naturally a parameterized verification problem. Parametrized verification techniques work by using sound abstractions to reduce the unbounded model to a bounded model. Efficient abstractions which work well for industrial scale protocols typically bound the model by replacing the state of most of the agents by an abstract environment, while keeping just one or two agents as is. However, leveraging such efficient abstractions becomes a challenge for s-deadlock: a violation of s-deadlock is a state in which the transitions of all of the unbounded number of agents cannot occur and so a simple abstraction like the one above will not preserve this violation. In this work we address this challenge by presenting a technique which leverages high-level information about the protocols, in the form of message sequence dia- grams referred to as flows, for constructing invariants that are collectively stronger than s-deadlock. Efficient abstractions can be constructed to verify these invariants. We successfully verify the German and Flash protocols using our technique

Discrete solvent effects on the effective interaction between charged colloids

Using computer simulations of two charged colloidal spheres with their counterions in a hard sphere solvent, we show that the granular nature of the solvent significantly influences the effective colloidal interaction. For divalent counterions, the total effective force can become attractive generated by counterion hydration, while for monovalent counterions the forces are repulsive and well-described by a solvent-induced colloidal charge renormalization. Both effects are not contained in the traditional "primitive" approaches but can be accounted for in a solvent-averaged primitive model.Comment: 4 pages, 3 figure

Thermal Model Calibration for Minor Planets Observed with Wide-Field Infrared Survey Explorer/Neowise

With the Wide-field Infrared Survey Explorer (WISE), we have observed over 157,000 minor planets. Included in these are a number of near-Earth objects, main-belt asteroids, and irregular satellites which have well measured physical properties (via radar studies and in situ imaging) such as diameters. We have used these objects to validate models of thermal emission and reflected sunlight using the WISE measurements, as well as the color corrections derived in Wright et al. for the four WISE bandpasses as a function of effective temperature. We have used 50 objects with diameters measured by radar or in situ imaging to characterize the systematic errors implicit in using the WISE data with a faceted spherical near-Earth asteroid thermal model (NEATM) to compute diameters and albedos. By using the previously measured diameters and H magnitudes with a spherical NEATM model, we compute the predicted fluxes (after applying the color corrections given in Wright et al.) in each of the four WISE bands and compare them to the measured magnitudes. We find minimum systematic flux errors of 5%-10%, and hence minimum relative diameter and albedo errors of ~10% and ~20%, respectively. Additionally, visible albedos for the objects are computed and compared to the albedos at 3.4 μm and 4.6 μm, which contain a combination of reflected sunlight and thermal emission for most minor planets observed by WISE. Finally, we derive a linear relationship between subsolar temperature and effective temperature, which allows the color corrections given in Wright et al. to be used for minor planets by computing only subsolar temperature instead of a faceted thermophysical model. The thermal models derived in this paper are not intended to supplant previous measurements made using radar or spacecraft imaging; rather, we have used them to characterize the errors that should be expected when computing diameters and albedos of minor planets observed by WISE using a spherical NEATM model

Properties of the superconducting state in a two-band model

Eliashberg theory is used to investigate the range of thermodynamic properties possible within a two-band model for s-wave superconductivity and to identify signatures of its two-band nature. We emphasize dimensionless BCS ratios (those for the energy gaps, the specific heat jump and the negative of its slope near Tc, the thermodynamic critical field Hc(0), and the normalized slopes of the critical field and the penetration depth near Tc), which are no longer universal even in weak coupling. We also give results for temperature-dependent quantities, such as the penetration depth and the energy gap. Results are presented both for microscopic parameters appropriate to MgB2 and for variations away from these. Strong coupling corrections are identified and found to be significant. Analytic formulas are provided which show the role played by the anisotropy in coupling in some special limits. Particular emphasis is placed on small interband coupling and on the opposite limit of no diagonal coupling. The effect of impurity scattering is considered, particularly for the interband case.Comment: 20 pages, 14 figures, final version accepted in PR

Theory of Tunneling for Rough Junctions

A formally exact expression for the tunneling current, for its separation into specular and diffuse components, and for its directionality, is given for a thick tunnel junction with rough interfaces in terms of the properties of appropriately defined scattering amplitudes. An approximate evaluation yields the relative magnitudes of the specular and diffuse components, and the angular dependence of the diffuse component, in terms of certain statistical properties of the junction interfaces.Comment: 4 page