X-chromosome inactivation mosaicism in the three germ layers and the germ line of the mouse embryo

Electrophoretic variant forms of the X-linked enzyme phosphoglycerate kinase (PGK-1, E.C.2, 7, 2, 3) have been used to examine X-chromosome mosaicism in tissues from 121/2-day post coitum heterozygous female mouse embryos. Samples of yolk-sac endoderm, neural ectoderm, heart (mesoderm), liver (endoderm) and germ cells were analysed from each embryo. In all tissues except yolk-sac endoderm, both PGK-1 isozymes were expressed. The extent of covariance among tissues with respect to the PGK-1 isozyme contribution is consistent with all tissues being derived from the same pool of cells after X-inactivation. The covariance among tissues gives an estimate of the size of this pool (47 cells) and places the earliest time of X-inactivation in epiblast cells between 41/2 and 51/2 days post coitum. From the independent variance among tissues within an individual, the average primordial precursor pool size for the three germ layers and the germ line itself was estimated as 193 cells

Nonlinear Morphoelastic Plates I: Genesis of Residual Stress

Volumetric growth of an elastic body may give rise to residual stress. Here a rigorous analysis of the residual strains and stresses generated by growth in the axisymmetric Kirchhoff plate is given. Balance equations are derived via the global constraint principle, growth is incorporated via a multiplicative decomposition of the deformation gradient, and the system is closed by a response function. The particular case of a compressible neo-Hookean material is analyzed and the existence of residually stressed states is established

Nonlinear morphoelastic plates II: exodus to buckled states

Morphoelasticity is the theory of growing elastic materials. This theory is based on the multiple decomposition of the deformation gradient and provides a formulation of the deformation and stresses induced by growth. Following a companion paper, a general theory of growing nonlinear elastic Kirchhoff plate is described. First, a complete geometric description of incompatibility with simple examples is given. Second, the stability of growing Kirchhoff plates is analyzed

Design of an integrated shallow water wave experiment

The experimental design and instrumentation for an integrated shallow-water surface gravity wave experiment is discussed. The experiment required the measurement of the water surface elevation, meteorological parameters, and directional spectra at a number of locations on a shallow lake. In addition, to acquire data under a wide range of conditions, an experimental period of three years was required. A system of telephone and radio modem links were installed to enable real-time monitoring of instrument performance at eight separate measurement locations on the lake. This system also enabled logging sessions to be optimized to ensure the maximum possible data return from this extended experimentIEEE Oceanic Engineering Societ

HST imaging of hyperluminous infrared galaxies

We present HST WFPC2 I band imaging for a sample of 9 Hyperluminous Infrared Galaxies spanning a redshift range 0.45 < z < 1.34. Three of the sample have morphologies showing evidence for interactions, six are QSOs. Host galaxies in the QSOs are reliably detected out to z ~ 0.8. The detected QSO host galaxies have an elliptical morphology with scalelengths spanning 6.5 < r_{e}(Kpc) < 88 and absolute k corrected magnitudes spanning -24.5 < M_{I} < -25.2. There is no clear correlation between the IR power source and the optical morphology. None of the sources in the sample, including F15307+3252, show any evidence for gravitational lensing. We infer that the IR luminosities are thus real. Based on these results, and previous studies of HLIRGs, we conclude that this class of object is broadly consistent with being a simple extrapolation of the ULIRG population to higher luminosities; ULIRGs being mainly violently interacting systems powered by starbursts and/or AGN. Only a small number of sources whose infrared luminosities exceed 10^{13}Lsun are intrinsically less luminous objects which have been boosted by gravitational lensing.Comment: 16 Pages. Accepted for publication in MNRA