855 research outputs found
The agrin gene codes for a family of basal lamina proteins that differ in function and distribution
We isolated two cDNAs that encode isoforms of agrin, the basal lamina protein that mediates the motor neuron-induced aggregation of acetylcholine receptors on muscle fibers at the neuromuscular junction. Both proteins are the result of alternative splicing of the product of the agrin gene, but, unlike agrin, they are inactive in standard acetylcholine receptor aggregation assays. They lack one (agrin-related protein 1) or two (agrin-related protein 2) regions in agrin that are required for its activity. Expression studies provide evidence that both proteins are present in the nervous system and muscle and that, in muscle, myofibers and Schwann cells synthesize the agrin-related proteins while the axon terminals of motor neurons are the sole source of agrin
The Computational Power of Optimization in Online Learning
We consider the fundamental problem of prediction with expert advice where
the experts are "optimizable": there is a black-box optimization oracle that
can be used to compute, in constant time, the leading expert in retrospect at
any point in time. In this setting, we give a novel online algorithm that
attains vanishing regret with respect to experts in total
computation time. We also give a lower bound showing
that this running time cannot be improved (up to log factors) in the oracle
model, thereby exhibiting a quadratic speedup as compared to the standard,
oracle-free setting where the required time for vanishing regret is
. These results demonstrate an exponential gap between
the power of optimization in online learning and its power in statistical
learning: in the latter, an optimization oracle---i.e., an efficient empirical
risk minimizer---allows to learn a finite hypothesis class of size in time
. We also study the implications of our results to learning in
repeated zero-sum games, in a setting where the players have access to oracles
that compute, in constant time, their best-response to any mixed strategy of
their opponent. We show that the runtime required for approximating the minimax
value of the game in this setting is , yielding
again a quadratic improvement upon the oracle-free setting, where
is known to be tight
On the constitution of sodium at higher densities
Using density functional theory the atomic and electronic structure of sodium
are predicted to depart substantially from those expected of simple metals for
GPa). Newly-predicted phases include those with low
structural symmetry, semi-metallic electronic properties (including zero-gap
semiconducting limiting behavior), unconventional valence charge density
distributions, and even those that raise the possibility of superconductivity,
all at currently achievable pressures. Important differences emerge between
sodium and lithium at high densities, and these are attributable to
corresponding differences in their respective cores.Comment: 13 pages; 3 figure
Similarities between the Hubbard and Periodic Anderson Models at Finite Temperatures
The single band Hubbard and the two band Periodic Anderson Hamiltonians have
traditionally been applied to rather different physical problems - the Mott
transition and itinerant magnetism, and Kondo singlet formation and scattering
off localized magnetic states, respectively. In this paper, we compare the
magnetic and charge correlations, and spectral functions, of the two systems.
We show quantitatively that they exhibit remarkably similar behavior, including
a nearly identical topology of the finite temperature phase diagrams at
half-filling. We address potential implications of this for theories of the
rare earth ``volume collapse'' transition.Comment: 4 pages (RevTeX) including 4 figures in 7 eps files; as to appear in
Phys. Rev. Let
Pairing Correlations on t-U-J Ladders
Pairing correlations on generalized t-U-J two-leg ladders are reported. We
find that the pairing correlations on the usual t-U Hubbard ladder are
significantly enhanced by the addition of a nearest-neighbor exchange
interaction J. Likewise, these correlations are also enhanced for the t-J model
when the onsite Coulomb interaction is reduced from infinity. Moreover, the
pairing correlations are larger on a t-U-J ladder than on a t-Jeff ladder in
which Jeff has been adjusted so that the two models have the same spin gap at
half-filling. This enhancement of the pairing correlations is associated with
an increase in the pair-binding energy and the pair mobility in the t-U-J model
and point to the importance of the charge transfer nature of the cuprate
systems
Phase separation and valence instabilities in cuprate superconductors. Effective one-band model approach
We study the Cu-O valence instability (VI) and the related phase separation
(PS) driven by Cu-O nearest-neighbor repulsion , using an effective
extended one-band Hubbard model () obtained from the extended
three-bandHubbard model, through an appropriate low-energy reduction.
is solved by exact diagonalization of a square cluster with 10 unit cells and
also within a slave-boson mean-field theory. Its parameters depend on doping
for or on-site O repulsion . The results using both
techniques coincide in that there is neither VI nor PS for doping levels
if eV. The PS region begins for eV
at large doping and increases with increasing . The PS also
increases with increasing on-site Cu repulsion .Comment: 16 pages and 10 figures in postscript format, compressed with uufile
Low-frequency incommensurate magnetic response in strongly correlated systems
It is shown that in the t-J model of Cu-O planes at low frequencies the
dynamic spin structure factor is peaked at incommensurate wave vectors
(1/2+-delta,1/2)$, (1/2,1/2+-delta). The incommensurability is connected with
the momentum dependencies of the magnon frequency and damping near the
antiferromagnetic wave vector. The behavior of the incommensurate peaks is
similar to that observed in La_{2-x}(Ba,Sr)_xCuO_{4+y} and YBa_2Cu_3O_{7-y}:
for hole concentrations 0.02<x<=0.12 we find that delta is nearly proportional
to x, while for x>0.12 it tends to saturation. The incommensurability
disappears with increasing temperature. Generally the incommensurate magnetic
response is not accompanied by an inhomogeneity of the carrier density.Comment: 4 pages, 4 figure
Dynamical Mean-Field Theory and Its Applications to Real Materials
Dynamical mean-field theory (DMFT) is a non-perturbative technique for the
investigation of correlated electron systems. Its combination with the local
density approximation (LDA) has recently led to a material-specific
computational scheme for the ab initio investigation of correlated electron
materials. The set-up of this approach and its application to materials such as
(Sr,Ca)VO_3, V_2O_3, and Cerium is discussed. The calculated spectra are
compared with the spectroscopically measured electronic excitation spectra. The
surprising similarity between the spectra of the single-impurity Anderson model
and of correlated bulk materials is also addressed.Comment: 20 pages, 9 figures, invited paper for the JPSJ Special Issue "Kondo
Effect - 40 Years after the Discovery"; final version, references adde
Quantum Monte Carlo Study of Hole Binding and Pairing Correlations in the Three-Band Hubbard Model
We simulated the 3-band Hubbard model using the Constrained Path Monte Carlo
(CPMC) method in search for a possible superconducting ground state. The CPMC
is a ground state method which is free of the exponential scaling of computing
time with system size. We calculated the binding energy of a pair of holes for
systems up to unit cells. We also studied the pairing correlation
functions versus distance for both the d-wave and extended s-wave channels in
systems up to . We found that holes bind for a wide range of
parameters and that the binding increased as the system size is increased.
However, the pairing correlation functions decay quickly with distance.
For the extended s channel, we found that as the Coulomb interaction on
the Cu sites is increased, the long-range part of the correlation functions is
suppressed and fluctuates around zero. For the channel, we
found that the correlations decay rapidly with distance towards a small
positive value. However, this value becomes smaller as the interaction or
the system size is increased.Comment: 21 pages, 13 Postscript figures, Submitted to Phys. Rev.
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