NICMOS Observations of Low-Redshift Quasar Host Galaxies

We have obtained Near-Infrared Camera and Multi-Object Spectrometer images of 16 radio quiet quasars observed as part of a project to investigate the ``luminosity/host-mass limit.'' The limit results were presented in McLeod, Rieke, & Storrie-Lombardi (1999). In this paper, we present the images themselves, along with 1- and 2-dimensional analyses of the host galaxy properties. We find that our model-independent 1D technique is reliable for use on ground-based data at low redshifts; that many radio-quiet quasars live in deVaucouleurs-law hosts, although some of the techniques used to determine host type are questionable; that complex structure is found in many of the hosts, but that there are some hosts that are very smooth and symmetric; and that the nuclei radiate at ~2-20% of the Eddington rate based on the assumption that all galaxies have central black holes with a constant mass fraction of 0.6%. Despite targeting hard-to-resolve hosts, we have failed to find any that imply super-Eddington accretion rates.Comment: To appear in ApJ, 28 pages including degraded figures. Download the paper with full-resolutio figures from http://www.astro.wellesley.edu/kmcleod/mm.p

Unveiling the nature of bright z ~ 7 galaxies with the Hubble Space Telescope

We present new Hubble Space Telescope/Wide Field Camera 3 imaging of 25 extremely luminous (-23.2 < M_ UV < -21.2) Lyman-break galaxies (LBGs) at z ~ 7. The sample was initially selected from 1.65 deg^2 of ground-based imaging in the UltraVISTA/COSMOS and UDS/SXDS fields, and includes the extreme Lyman-alpha emitters, `Himiko' and `CR7'. A deconfusion analysis of the deep Spitzer photometry available suggests that these galaxies exhibit strong rest-frame optical nebular emission lines (EW_0(H_beta + [OIII]) > 600A). We find that irregular, multiple-component morphologies suggestive of clumpy or merging systems are common (f_multi > 0.4) in bright z ~ 7 galaxies, and ubiquitous at the very bright end (M_UV < -22.5). The galaxies have half-light radii in the range r_1/2 ~ 0.5-3 kpc. The size measurements provide the first determination of the size-luminosity relation at z ~ 7 that extends to M_UV ~ -23. We find the relation to be steep with r_1/2 ~ L^1/2. Excluding clumpy, multi-component galaxies however, we find a shallower relation that implies an increased star-formation rate surface density in bright LBGs. Using the new, independent, HST/WFC3 data we confirm that the rest-frame UV luminosity function at z ~ 7 favours a power-law decline at the bright-end, compared to an exponential Schechter function drop-off. Finally, these results have important implications for the Euclid mission, which we predict will detect > 1000 similarly bright galaxies at z ~ 7. Our new HST imaging suggests that the vast majority of these galaxies will be spatially resolved by Euclid, mitigating concerns over dwarf star contamination.Comment: 26 pages, 11 figures and 5 tables. Updated to match MNRAS accepted versio

Plasmonic Hot Spots in Triangular Tapered Graphene Microcrystals

Recently, plasmons in graphene have been observed experimentally using scattering scanning near-field optical microscopy. In this paper, we develop a simplified analytical approach to describe the behavior in triangular samples. Replacing Coulomb interaction by a short-range one reduces the problem to a Helmholtz equation, amenable to analytical treatment. We demonstrate that even with our simplifications, the system still exhibits the key features seen in the experiment.Comment: 4 pages, 3 figure

Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial

Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity. A candidate gene study was conducted to assess potential association of genetic variants with GI toxicity in 808 patients who received carboplatin/taxane in the Scottish Randomized Trial in Ovarian Cancer 1 (SCOTROC1). Patients were randomized into discovery and validation cohorts consisting of 404 patients each. Clinical covariates and genetic variants associated with grade III/IV GI toxicity in discovery cohort were evaluated in replication cohort. Chemotherapy-induced GI toxicity was significantly associated with seven single-nucleotide polymorphisms in the ATP7B, GSR, VEGFA and SCN10A genes. Patients with risk genotypes were at 1.53 to 18.01 higher odds to develop carboplatin/taxane-induced GI toxicity (P&#60;0.01). Variants in the VEGF gene were marginally associated with survival time. Our data provide potential targets for modulation/inhibition of GI toxicity in ovarian cancer patients

Results from the CASTLES Survey of Gravitational Lenses

We show that most gravitational lenses lie on the passively evolving fundamental plane for early-type galaxies. For burst star formation models (1 Gyr of star formation, then quiescence) in low Omega_0 cosmologies, the stellar populations of the lens galaxies must have formed at z_f > 2. Typical lens galaxies contain modest amounts of patchy extinction, with a median differential extinction for the optical (radio) selected lenses of E(B-V) = 0.04 (0.07) mag. The dust can be used to determine both extinction laws and lens redshifts. For example, the z_l=0.96 elliptical lens in MG0414+0534 has an R_V=1.7 +/- 0.1 mean extinction law. Arc and ring images of the quasar and AGN source host galaxies are commonly seen in NICMOS H band observations. The hosts are typically blue, L < L_* galaxies.Comment: 12 pages, 10 figures, from Proceedings of the 9th Annual Astrophysics Conference in Maryland, After the Dark Ages: When Galaxies Were Youn