Induction of Colonic Aberrant Crypts in Mice by Feeding Apparent N-Nitroso Compounds Derived From Hot Dogs

Nitrite-preserved meats (e.g., hot dogs) may help cause colon cancer because they contain N-nitroso compounds. We tested whether purified hot-dog-derived total apparent N-nitroso compounds (ANC) could induce colonic aberrant crypts, which are putative precursors of colon cancer. We purified ANC precursors in hot dogs and nitrosated them to produce ANC. In preliminary tests, CF1 mice received 1 or 3 i.p. injections of 5mg azoxymethane (AOM)/kg. In Experiments 1 and 2, female A/J mice received ANC in diet. In Experiment 1, ANC dose initially dropped sharply because the ANC precursors had mostly decomposed but, later in Experiment 1 and throughout Experiment 2, ANC remained at 85 nmol/g diet. Mice were killed after 8 (AOM tests) or 17–34 (ANC tests) wk.Median numbers of aberrant crypts in the distal 2 cm of the colon for 1 and 3 AOMinjections, CF1 controls, ANC (Experiment 1), ANC (Experiment 2),and untreated A/J mice were 31, 74, 12, 20, 12, and 5–6, with P < 0.01 for both ANC tests. Experiment 2 showed somewhat increased numbers of colonic mucin-depleted foci in the ANC-treated group. We conclude that hot-dog-derived ANC induced significant numbers of aberrant crypts in the mouse colon

Early Winter Habitat Use by Mountain Caribou in the North Cariboo and Columbia Mountains, British Columbia

Winter habitat use was compared between two mountain caribou (Rangifer tarandus caribou) populations in British Columbia. Regional differences were apparent during November and December. Radio-collared caribou inhabiting the gentle plateaus of the northern Cariboo Mountains, near Prince George, B.C. primarily used mid-elevation balsam-spruce stands on moderate slopes (&lt;30%). In contrast, radio-collared caribou in the North Columbia Mountains, near Revelstoke, B.C. used low elevation hemlock-cedar stands and relatively steeper slopes (&gt;30%). To adequately address habitat requirements of caribou, forest management plans should incorporate varying regional and seasonal habitat use patterns. Hypotheses on observed differences in habitat use are discussed

Evidence for Infanticide in Bottlenose Dolphins of the Western North Atlantic

Nine bottlenose dolphin (Tursiops truncatus) calves that stranded in Virginia in 1996 and 1997 died of severe blunt-force trauma. Injuries were concentrated on the head and chest and multiple rib fractures, lung lacerations, and soft tissue contusions were prominent. Skeletal and/or soft tissue trauma occurred bilaterally in all of the calves. One had a bite wound across the left mandible that exhibited deep punctures consistent with the tooth placement in an adult bottlenose dolphin. The lesions were not compatible with predation, boat strike, fisheries interactions, rough-surf injury, or blast injury. However, they were similar to traumatic injuries described in stranded bottlenose dolphin calves and harbor porpoises (Phocoena phocoena) in Great Britain attributed to violent dolphin interactions. The evidence suggests that violent dolphin behavior was the cause of the trauma in the nine calves reported here and that infanticide occurs in bottlenose dolphins of the western North Atlantic

NON-HYDROSTATIC THERMODYNAMICS OF CHEMICAL AND PHASE CHANGES

ABSTRACT The problem of chemical or phase equilibrium under non-hydrostatic stresses is discussed. It is shown how to formulate a formal thermodynamic theory, the essential step being the correct definition of the mechanical coordinates so that they describe not only the change of shape but the work done in such processes as deformation, chemical action, crystallization or solution at a surface, or a phase change. A useful Gibbs function is defined to give the conditions of equilibrium for the above processes. The theory agrees with experiments on the c-3 quartz transition and on the de-twinning of quartz

The distribution, origin and use of sand and gravel deposits in central Lanarkshire

No abstract

Electric and hydrogen rail : Potential contribution to net zero in the UK

Acknowledgements  This research was carried out under the UK Energy Research Centre (UKERC) as part of the ADdressing Valuation of Energy and Nature Together (ADVENT) funded project. Funding was received from the Natural Environment Research Council (NE/M019691/1), United Kingdom and the School of Biological Sciences, University of Aberdeen, United Kingdom. The authors would also like to thank Dr Christian Brand, University of Oxford, for giving them access to the Transport Energy and Air Pollution Model (TEAM-UK).Peer reviewedPublisher PD

Japan and the UK : Emission predictions of electric and hydrogen rail to 2050

Acknowledgements This research was carried out under the UK Energy Research Centre (UKERC) as part of the ADdressing Valuation of Energy and Nature Together (ADVENT) funded project. Funding was received from the Natural Environment Research Council (NE/M019691/1), United Kingdom and the School of Biological Sciences, University of Aberdeen, United Kingdom. Funding was also received from the Postgraduate Research Grant from University of Aberdeen, United Kingdom. This work has also emanated from research supported in part by a research grant from Science Foundation Ireland (SFI) under the SFI Strategic Partnership Programme Grant number SFI/15/SPP/E3125. The authors would also like to thank Dr Christian Brand, University of Oxford, for giving them access and guidance regarding the Trans- port Energy and Air Pollution Model (TEAM‐UK).Peer reviewedPublisher PD