Calculations, and comparison with an ideal minimum, of trimmed drag for conventional and canard configurations having various levels of static stability

Classical drag equations were used to calculate total and induced drag and ratios of stabilizer lift to wing lift for a variety of conventional and canard configurations. The Flight efficiencies of such configurations that are trimmed in pitch and have various values of static margin are evaluated. Classical calculation methods are compared with more modern lifting surface theory

NOC turbulence glider deployment report for the Liverpool Bay Coastal Observatory, June 2011 deployment

A summary of the NOC Liverpool turbulence glider deployment that occurred between Tuesday 28th June and Monday 4th July 2011 is provided in this document. The general objective of the deployment was to hold the glider on station at a nominal GPS location of 53o 48”N, -4o 00”W to provide a series of glider based turbulence probe and CTD data profiles. These profiles were initiated when the glider reached a nominal depth of 40 metres and continued until the glider approached the sea surface. The glider deployment site was selected to be away from the influence of fresh water influx into the Liverpool Bay and in a position that avoids scheduled shipping routes. The recorded glider data was compared with a seabed instrumentation frame that was deployed at the same nominal location. The instrumentation frame had a Seabird CTD and a 5 axis upward measuring ADCP with a vertical turbulence measurement capability installed. During the glider deployment cruise reference water samples and independent CTD measurements were collected for deployed instrumentation and glider sensor calibration purpose

Clinical and laboratory studies of the bacterial pathogenesis and management of Pouchitis

20-50% of patients develop pouchitis following restorative proctocolectomy for ulcerative colitis (UC). Pre-pouch ileitis (PPI) also develops in some of these patients. Bacteria are implicated in the pathogenesis of pouchitis and antibiotics are the mainstay of treatment. Studies were performed to examine the role of bacteria in the pathogenesis of this disease and to develop new treatment. Further studies examined the prevalence and implications of PPI and the efficacy and complications associated with maintenance antibiotic therapy. 16s rRNA sequencing demonstrated an increase in Proteobacteria and a reduction in Bacteroidetes in the UC compared with the familial adenomatous polyposis (FAP) cohort, but only limited differences between the UC non-pouchitis and pouchitis groups. We were unable to identify an individual species or phylotype specifically associated with pouchitis. Treatment with elemental diet produced a symptomatic improvement in 71% of chronic pouchitis patients but none entered clinical remission. Patients with PPI were identified, the prevalence, symptoms and short term outcomes of this group were studied. PPI was identified in 5.7% of patients with UC. All patients had associated pouchitis but not all were symptomatic. PPI was not associated with reclassification to Crohn’s disease. A subgroup of patients with symptomatic pre-pouch ileitis were treated with combination antibiotic therapy and 86% entered remission. Faecal samples from patients with antibiotic resistant pouchitis were grown on agar and sensitivity patterns identified. Following guided antibiotic therapy 80% of patients entered remission. Stool analysis also identified the presence of extended spectrum beta-lactamase (ESBL) resistant coliforms in 35% of patients with chronic pouchitis. Not all were symptomatic. PPI was associated with an increased risk of ESBL. Patients treated with maintenance antibiotic therapy were identified. Pre-pouch ileitis was associated with an increased risk of relapse. Reported side effects were rare and treatment was associated with an improved quality of life

A bright millisecond radio burst of extragalactic origin

Pulsar surveys offer one of the few opportunities to monitor even a small fraction (~0.00001) of the radio sky for impulsive burst-like events with millisecond durations. In analysis of archival survey data, we have discovered a 30-Jy dispersed burst of duration <5 ms located three degrees from the Small Magellanic Cloud. The burst properties argue against a physical association with our Galaxy or the Small Magellanic Cloud. Current models for the free electron content in the Universe imply a distance to the burst of <1 Gpc No further bursts are seen in 90-hr of additional observations, implying that it was a singular event such as a supernova or coalescence of relativistic objects. Hundreds of similar events could occur every day and act as insightful cosmological probes.Comment: 18 pages, 4 figures. Accepted by Science. Published electronically via Science Express on September 27, 200