The Grizzly, March 29, 1985

St. Joe\u27s to Offer MBA Program on Ursinus Campus • New Poli Sci Professor Hired • Main St. Renovations Scheduled • Co-ed Housing to Start Next Year in Reimert Complex • Community Opposes Vigilantes • Dining Committee Presents New Recipe Program • Car Stairs, S.P.E.C.T.E.R. Undefeated in College Bowl • Student Relates German Experience • Defending Champs Open Lax Season with Win • Baseball Squad Off to Sluggish Start • New Coach Readies Golfers for Tough Week • Senior Diver Finishes 19th in NCAA Championshipshttps://digitalcommons.ursinus.edu/grizzlynews/1137/thumbnail.jp

The Grizzly, May 3, 1985

Reimert Hall Will Welcome Girls in the Fall • Fraternities Are Still Alive at Ursinus • Ursinus Applicants Improve • Letters: Greek Week Disappointing; Radio Offers Thanks • Drinking Age of 21 Should Not Be a Standard • Profile: Dr. Coggers Says Farewell • Greek Week\u27s Final Results • Lacrosse Looks to Repeat Division III Title • Successful Year for Lacrosse Club • Gasser Retires • Sally Grim Shines As Star Pitcher • Griffin Worth Far More than Gold • Trackmen Head to MAC\u27s • Stormy Baver is Pilot Behind the Plate • Golf Team Optimistic • Visit the Writing Center • 1985 Baseball Wraps it Up • 1985 Lacrosse Stats • St. Joseph\u27s M.B.A Courses Offered at Ursinus • Open Dialog On Intervention • Area Residents Share College Memories • Shorts: Faculty Members to Retire; Open Dialog; Color Analysis Held on Campus; Evening Concert Announced; Voices ; Art Show • Dead Kennedys • WVOU Conducts Survey • Luau on Sat. • Weekend Highlights • It Will Be a Fantasy Weekendhttps://digitalcommons.ursinus.edu/grizzlynews/1142/thumbnail.jp

The Grizzly, April 18, 1986

The Bomb is Dropped; Policy Could Can Kegs • Admissions Video to Draw High School Seniors • CAB Spring Weekend Twists Around the Corner! • Administration\u27s Letter: Clearing Up the Cloudy Water • Get Your Ruby • Proposed Alcohol Regulations • Political Science\u27s Fitzpatrick to Focus on Constitution • Richter Joins Pavarotti • Greek Week Results • College Republicans Meet in Harrisburg • Perreten in Select Group to Interpret Humanities • Novack to Study Technology\u27s Effects on French Life • Lift-A-Thon: Pressing Weights for Progress • Women\u27s LAX Takes Two • Linksters Drive to 7-1 Record • Men\u27s LAX Strong at 5-2 • Rowson a Threat for Gold in Five Events • A Sterling Suggestion! Brown to be Tattooed • O\u27Toole Hurdles School Record • Men\u27s Tennis • Bears Battle Back • Hadler\u27s Medical Serieshttps://digitalcommons.ursinus.edu/grizzlynews/1988/thumbnail.jp

The Grizzly, April 26, 1985

Greek Week Comes to a Close • Economics Council Hosts Speakers • Class Attendance • Airbands Raise Money for Hungry • Letters: Teachers Needed • Outstanding Educators • Seniors Honored as Chapter Scholars • Shorts: Giunta Named Truman Scholar; Comet Looked at; Voices Called For; Pick-a-prof; U.C. Sees D.C.; Spring Concert; 550 Fast! • U2 Unforgettable at Spectrum • Fans Grateful Band is Still Alive • Day Shines the Light on Winning • UC Beats Div.I Delaware • Heading Toward a Winning Season • Politics is Just Another Goal Scored • Bravo Performs on Both Decks • Bears Look Good: MACs Coming • Flyers Quest for Cup • Cordes Scores Big at Temple • Intramural Softballhttps://digitalcommons.ursinus.edu/grizzlynews/1141/thumbnail.jp

The Grizzly, April 11, 1986

Collegeville Water: Poison • Toombs Speaks on Real Estate • The Time has Come • Wismer, be Realistic! • Letter: Administration Housing Plans are Unfair • Former U.C. Graduate Plays Important Role in Recovery of Challenger Debris • Hair Sneak Preview • Take C and C and See the Progress of Humanity • Greeks Flail Booze Curtail • Looking for Alternatives to the Joys of Alcohol • Women\u27s Lacrosse Wins Five in a Row • Linksters Off to a Great Start • Bears Drop to 4-8 • Women\u27s Track • Profile: Marc Dervishian • Women\u27s Softball Season Heats Up • Women\u27s Tennis Falls to 1-4 • Profile: Leigh Garrison • Gung Ho for Howard • Music: It gets the Irish in me Goinghttps://digitalcommons.ursinus.edu/grizzlynews/1163/thumbnail.jp

DNA-Binding and Transactivation Activities Are Essential for TAp63 Protein Degradation

The p53-related p63 gene encodes six isoforms with differing N and C termini. TAp63 isoforms possess a transactivation domain at the N terminus and are able to transactivate a set of genes, including some targets downstream of p53. Accumulating evidence indicates that TAp63 plays an important role in regulation of cell proliferation, differentiation, and apoptosis, whereas transactivation-inert ΔNp63 functions to inhibit p63 and other p53 family members. Mutations in the p63 gene that abolish p63 DNA-binding and transactivation activities cause human diseases, including ectrodactyly ectodermal dysplasia and facial clefting (EEC) syndrome. In this study, we show that mutant p63 proteins with a single amino acid substitution found in EEC syndrome are DNA binding deficient, transactivation inert, and highly stable. We demonstrate that TAp63 protein expression is tightly controlled by its specific DNA-binding and transactivation activities and that p63 is degraded in a proteasome-dependent, MDM2-independent pathway. In addition, the N-terminal transactivation domain of p63 is indispensable for its protein degradation. Furthermore, the wild-type TAp63γ can act in trans to promote degradation of mutant TAp63γ defective in DNA binding, and the TA domain deletion mutant of TAp63γ inhibits transactivation activity and stabilizes the wild-type TAp63 protein. Taken together, these data suggest a feedback loop for p63 regulation, analogous to the p53-MDM2 feedback loop